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| 1 | Modern treatment of gastric gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors (GIST) are rare mesenchymal smooth muscle sarcomas that can arise anywhere within the gastrointestinal tract. Sporadic mutations within the tyrosine kinase receptors of the interstitial cells of Cajal have been identified as the key molecular step in GIST carcinogenesis. Although many patients are asymptomatic, the most common associated symptoms include: abdominal pain, dyspepsia, gastric outlet obstruction, and anorexia. Rarely, GIST can perforate causing life-threatening hemoperitoneum. Most are ultimately diagnosed on cross-sectional imaging studies (i.e., computed tomography and/or magnetic resonance imaging in combination with upper endoscopy. Endoscopic ultrasonographic localization of these tumors within the smooth muscle layer and acquisition of neoplastic spindle cells harboring mutations in the c-KIT gene is pathognomonic. Curative treatment requires a complete gross resection of the tumor. Both open and minimally invasive operations have been shown to reduce recurrence rates and improve long-term survival. While there is considerable debate over whether GIST can be benign neoplasms, we believe that all GIST have malignant potential, but vary in their propensity to recur after resection and metastasize to distant organ sites. Prognostic factors include location, size (i.e., > 5 cm), grade (> 5-10 mitoses per 50 high power fields and specific mutational events that are still being defined. Adjuvant therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to reduce the risk of recurrence after one year of therapy. Treatment of locally-advanced or borderline resectable gastric GIST with neoadjuvant imatinib has been shown to induce regression in a minority of patients and stabilization in the majority of cases. This treatment strategy potentially reduces the need for more extensive surgical resections and increases the number of patients eligible for curative therapy. The modern surgical treatment of gastric GIST combines the novel use of targeted therapy and aggressive minimally invasive surgical procedures to provide effective treatment for this lethal, but rare gastrointestinal malignancy. | Kevin K Roggin Mitchell C Posner | 2012 | World Journal of Gastroenterology2012，18，46： | 17 |
| 2 | Central pancreatectomy revisited显示文摘 | Kevin K. Roggin M.D. Udo Rudloff M.D. Leslie H. Blumgart M.D. Murray F. Brennan M.D | 2006 | Journal of Gastrointestinal Surgery2006，，6： | 3 |
| 3 | Limitations of Ampullectomy in the Treatment of Nonfamilial Ampullary Neoplasms显示文摘 | Kevin K. Roggin MD Jen Jen J. Yeh MD Cristina R. Ferrone MD Elyn Riedel MS Hans Gerdes MD David S. Klimstra MD David P. Jaques MD Murray F. Brennan MD | 2005 | Annals of Surgical Oncology2005，，12： | 2 |
| 4 | Pancreatic cystic neoplasm显示文摘 | Roggin KK Chennat J Oto A | 2010 | Curr Probl Surg2010，47，6： | 1 |
| 5 | Surgical manage-ment of pancreaticobiliary disease associated with juxtapapil-iary duodenal diverticula: case series and review of the litera-ture 显示文摘 | Teven CM Grossman E Roggin KK | 2012 | J Gastrointest Surg2012，16，7： | 1 |
| 6 | Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors显示文摘 | Untch BR Bonner KP Roggin KK | 2014 | J Castrointest Surg2014，18，45： | 1 |
| 7 | Papillary Phenotype Confers Improved Survival After Resection of Hilar Cholangiocarcinoma显示文摘 | William R. Jarnagin Wilbur Bowne David S. Klimstra Leah Ben-Porat Kevin Roggin Karina Cymes Yuman Fong Ronald P. DeMatteo Michael D?Angelica Jonathan Koea Leslie H. Blumgart | 2005 | Annals of Surgery2005，，5： | 1 |
| 8 | Seasonal variability in emission of nitrous oxide from soil显示文摘 | Brernner J M Roggins S G Blackmer A M | 1980 | Geophysical Research Letters1980，7，： | 1 |
| 9 | Central pancreateetomy revisited显示文摘 | Roggin K K Rudloff U Blumgart L H | 2006 | J Gastrointest Surg2006，10，6： | 1 |
| 10 | Central pancreatectomy revisited显示文摘 | Kevin K. Roggin M.D. Udo Rudloff M.D. Leslie H. Blumgart M.D. Murray F. Brennan M.D | 2006 | Journal of Gastrointestinal Surgery2006，，6： | 1 |
| 11 | Central pancreatectomy revisited 显示文摘 | Roggin KK Rudloff U Blumgart LH | 2006 | J Gastrointest Surg2006，10，： | 1 |
| 12 | Prospective clinical trim of diagnostic peritoneal lavage to detect positive peritoneal cytology in patients with gastric cancer 显示文摘 | Mezhir JJ Posner MC Roggin KK | 2013 | J Surg Oncol2013，107，8： | 1 |
| 13 | Central pancreatectomy revisited 显示文摘 | Roggin KK Runoff U | 2006 | J Gastrointest Surg2006，10，6： | 1 |
| 14 | Central pancreatectomy revisited显示文摘 | Roggin KK Rudloff U Blumgart LH | 2006 | J Gastrointest Surg2006，，6： | 1 |
| 15 | Prospective clinical trial of diagnostic peritoneal lavage to detect positive peritoneal cytology in patients with gastric cancer显示文摘 | James J. Mezhir Mitchell C. Posner Kevin K. Roggin | 2013 | J Surg Oncol2013，，8： | 1 |
| 16 | Central pancreatectomy revisited显示文摘 | Roggin K K Rudloff U Blumgart L H | | 0，，： | 1 |
| 17 | Macrophage phenotype during cholestatic injury and repair:the persistent inflammatory response显示文摘 | Roggin KK Kim JC Kurkchubasche AG | 2001 | J Pediatr Surg2001，36，1： | 1 |
| 18 | Macrophage phenotype during cholestatic injury and repair: The persistent inflammatory response显示文摘 | Roggin KK Kim JC Kurkchubasche AG | 2001 | J Pediatr Surg2001，36，： | 1 |
| 19 | Macrophage phenotype during cholestatic injury and repair:the persistent inflammatory response显示文摘 | Roggin KK Kim JC Kurkchubasche AG | 2001 | J Pediatr Surg2001，36，1： | 1 |
| 20 | Central pancreatectomy revisited显示文摘 | Roggin KK Rudloff U Blumgart LH | 2006 | J Gastrointest Surg2006，6，： | 1 |
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