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| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet显示文摘AIM: To determine the fasting plasma carnitine ester in patients with celiac disease.METHODS: We determined the fasting plasma carnitine ester profile using ESI triple quadrupol mass spectrometry in 33 adult patients with biopsy-confirmed maturity onset celiac disease maintained on long term gluten free diet.RESULIS: The level of free camitine did not differ as the celiac disease patients were compared with the healthy controls, whereas the acetylcarnitine level was markedly reduced (4.703 ± 0.205 vs 10.227 ± 0.368 nmol/mL,P<0.01). The level of propionylcarnitine was 61.5%,butyrylcarnitine 56.9%, hexanoylcarnitine 75%,octanoylcarnitine 71.1%, octenoylcarnitine 52.1%,decanoylcarnitine 73.1%, cecenoylcarnitine 58.3%,lauroylcarnitine 61.5%, miristoylcarnitine 66.7%,miristoleylcarnitine 62.5% and oleylcarnitine 81.1%in the celiac disease patients compared to the control values, respectively (P<0.01).CONCLUSION: The marked decrease of circulating acetylcarnitine with 50-80 % decrease of 11 other carnitine esters shows that the carnitine ester metabolism can be influenced even in clinically asymptomatic and well being adult celiac disease patients, and gluten withdrawal alone does not necessarily normalize all elements of the disturbed carnitine homeostasis. | Judit Bene Katalin Komlósi Beáta Gasztonyi Márk Juhász Zsolt Tulassay Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，42： | 5 |
| 3 | Determination of physical properties of planetary sub-surface layers by artificial impacts and penetrometry 显示文摘 | KOMLE N I KANG G BALL A J | 2001 | Adv Space Res2001，28，10： | 1 |
| 4 | On optimal matchings显示文摘 | Komlós J Tusnády G | 1984 | Combinatorica1984，4，： | 1 |
| 5 | An approximation of partial sums of independent RV’-s, and the sample DF. I显示文摘 | J. Komlós P. Major G. Tusnády | 1975 | Zeitschrift für Wahrscheinlichkeitstheorie und Verwandte Gebiete (-)1975，，1： | 1 |
| 6 | Storing a Sparse Table with O(1) Worst Case Access Time显示文摘 | Fredman M Koml'os J Szemer'edi E | 1984 | Journal of the ACM1984，31，3： | 1 |
| 7 | Infantile hemangiomas and retinopathy of prematurity: clues to the regulation of vasculogenesis显示文摘 | Rachael M. Hyland Katalin Komlósi Brandon W. Alleman Marina Tolnai Laura M. Wood Edward F. Bell Tibor Ertl | 2013 | European Journal of Pediatrics2013，，： | 1 |
| 8 | Development of thermal sensors and drilling systems for lunar and planetary regoliths显示文摘 | Komle N I Kaufmann E Kargl G | 2007 | Advances in Space Research2007，，： | 1 |
| 9 | Simvastatin upregulatesBcl-2 expression and protects retinal neurons from early ische-mia/reperfusion injuiy in the rat retina显示文摘 | KoML Chen CF Peng PH Peng YH | 2011 | Exp Eye Res2011，93，5： | 1 |
| 10 | An approximation of partial sums of independent RV’s, and the sample DF. II显示文摘 | J. Komlós P. Major G. Tusnády | 1976 | Zeitschrift für Wahrscheinlichkeitstheorie und Verwandte Gebiete1976，，1： | 1 |
| 11 | Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis显示文摘瞄准:与溃疡的 culitis (UC ) 并且与健康控制题目相比在成年病人决定血浆肉毒碱酉旨侧面。方法:用 ESI 三倍的四极双人脚踏车团分光术,肉毒碱酉旨侧面与 UC 和 44 匹配年龄、匹配性的健康控制在 44 个病人被测量。结果:在免费肉毒碱与 UC 和健康控制在病人之间铺平的 fasting 没有有效差量。禁食 propionyl-(0.331 +/- 0.019 对 0.392 +/- 0.017 micromol/L ) , butyryl-(0.219 +/- 0.014 对 0.265 +/- 0.012 ) ,并且 isovalerylcarnitine (0.111 +/- 0.008 对 0.134 +/- 0.008 ) 层次在 UC 病人被减少。由对比,octanoyl-的水平( 0.147 +/- 0.009 对 0.114 +/- 0.008 ),decanoyl-( 0.180 +/- 0.012 对 0.137 +/- 0.008 ),myristoyl-( 0.048 +/- 0.003 对 0.039 +/- 0.003 ),palmitoyl-( 0.128 +/- 0.006 对 0.109 +/- 0.004 ),palmitoleyl-( 0.042 +/- 0.003 对 0.031 +/- 0.002 )并且 oleylcarnitine ( 0.183 +/- 0.007 对 0.163 +/- 0.007 ;P <
0.05 在所有比较) 与 UC 在病人被增加。结论:我们的数据在 UC 病人建议肉毒碱酉旨的选择参与,可能由于他们的改变的新陈代谢。 | Judit Bene Katalin Komlósi Viktória Havasi Gábor Talián Beáta Gasztonyi Krisztina Horváth Gyula Mózsik Béla Hunyady Béla Melegh Mária Figler | 2006 | World Journal of Gastroenterology2006，12，1： | 1 |
| 12 | An approximation of partial sums of independent RV’-s, and the sample DF. I显示文摘 | J. Komlós P. Major G. Tusnády | 1975 | Zeitschrift für Wahrscheinlichkeitstheorie und Verwandte Gebiete (-)1975，，1： | 1 |
| 13 | Plasma carnitine esterprofile in homozygous and heterozygous OCTN2 deficiency显示文摘 | Komlósi K Magyari L Talián GC | | 0，，24： | 1 |
| 14 | Using the anchoring device of a comet lander to determine surface mechanical properties显示文摘 | KOMLE N I BALL A J KARGL G | 1997 | Planetary and Space Science1997，45，12： | 1 |
| 15 | Prevalence of SLC22A4 1672T and SLC22A5 ?207C combination defined TC haplotype in Hungarian ulcerative colitis patients显示文摘 | Lili Magyari Judit Bene Katalin Komlósi Gábor Talián Bernadett Faragó Veronika Cs?ngei Luca Járomi Enik? Sáfrány Csilla Sipeky Lilla Lakner Márta Varga Beáta Gasztonyi Béla Melegh | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 16 | Amanita poisoning during the second trimester of pregnancy显示文摘 | I. Nagy G. Pogátsa-Murray S. Zalányi P. Komlósi F. László I. Ungi | 1994 | The Clinical Investigator1994，，10： | 1 |
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