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| 1 | Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis. | Lawrence M Knab Paul J Grippo David J Bentrem | 2014 | World Journal of Gastroenterology2014，20，31： | 9 |
| 2 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 3 | Leg ulcers in a pa- tient associated with hydroxyurea therapy 显示文摘 | Dissemond J Hoeft D Knab J | 2006 | Int J Der- mato12006，45，2： | 1 |
| 4 | Close relation of endothelial function in the human coronary and peripheral circulations显示文摘 | Todd J. Anderson Akimi Uehata Marie D. Gerhard Ian T. Meredith Sarah Knab Danielle Delagrange Eric H. Lieberman Peter Ganz Mark A. Creager Alan C. Yeung Andrew P. Selwyn | 1995 | Journal of the American College of Cardiology1995，，5： | 1 |
| 5 | Protein dynami- cal transition in terahertz dielectric response 显示文摘 | Markelz A G Knab J R Chen J Y | 2007 | Chemical Physics Letters2007，442，： | 1 |
| 6 | Push-pull sorbent-based pheresis and hemodiabsorption in the treatment of hepatic failure: preliminary results of a clinical trial with the BioLogic-DTPF System显示文摘 | Ash SR Steczko J Knab WR | 2000 | Ther Apher2000，4，： | 1 |
| 7 | Biomarker indicators for anaerobic oxidizers of methane in brackish-marine sediments with diffusive methane fluxes显示文摘 | Aquilina A Knab N J Knittel K | 2010 | Organic Geochemistry2010，41，4： | 1 |
| 8 | Subcortical structures involved in pain processing: evidence from single-trial fMRI 显示文摘 | Bingel U Quante M Knab R | 2002 | Pain2002，99，： | 1 |
| 9 | Interpolation of band-limited functions using the approximate prolate series显示文摘 | KNAB J J | 1979 | IEEE Trans Inform Theory (Corres)1979，25，6： | 1 |
| 10 | Anesthesia for orthopedic surgery in Pallister-Killian syndrome显示文摘 | Jana Knab Erhart W Heupel Daniel Steinmann | 2008 | Paediatric anaesthesia2008，18，7： | 1 |
| 11 | Magnetic susceptibility napping of roadside pollution 显示文摘 | Hoffmann V Knab M Apple E | 1999 | Journal of Geochemical Exploration1999，66，： | 1 |
| 12 | Microbial ecology of the dark ocean above,at,and below the seafloor显示文摘 | Orcutt BN Sylvan JB Knab N J | | 0，，02： | 1 |
| 13 | Low-field magnetic susceptibility: a proxy method of estimating increased pollution of different environmental systems显示文摘 | E. Petrovsky A. Kapi?ka N. Jordanova M. Knab V. Hoffmann | 2000 | Environmental Geology (-)2000，，3： | 1 |
| 14 | Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices显示文摘 | Bingel U Quante M Knab R | 2003 | Neuroimage2003，18，3： | 1 |
| 15 | Interpolation of bandlimited functions using the approximate prolate series显示文摘 | Knab J J | 1979 | IEEE Transactions on Information Theory1979，25，6： | 1 |
| 16 | Interpolation of band-limited functions using the approximate prolate series 显示文摘 | KNAB J J | 1979 | IEEE Trans Inform Theory (Cortes)1979，25，6： | 1 |
| 17 | Interpolation of band-limited functions using the approximate prolate series显示文摘 | KNAB J J | 1979 | IEEE Trans Inform Theory (Corres)1979，25，6： | 1 |
| 18 | Subcortical structures involved in pain processing: evidence from single-trial fMRI 显示文摘 | Bingel U Quante M Knab R | 2002 | Pain2002，99，12： | 1 |
| 19 | Magnetic susceptibility mapping of roadside pollution 显示文摘 | HOFFMAN V KNAB M APPEL E | 1999 | Journal of Geochemical Exploration1999，66，： | 1 |
| 20 | Leg ulcer in a patient associated with hydroxyurea therapy显示文摘 | Dissemond J Hoeft D Knab J | 2006 | Int J Dermatol2006，45，2： | 1 |
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