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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | Evidence of philopatry in sharks and implications for the management of shark fisheries显示文摘 | HUETER R E HEUPEL M R HEIST E J | 2005 | Journal of Northwest Atlantic Fishery Science2005，35，： | 1 |
| 3 | Inhibition of nitrate formation from hydroxyl-ammonium chloride? a simple assay for superoxide dismutase显示文摘 | Elstner E F Heupel A | 1976 | Anal Ko-chem1976，70，： | 1 |
| 4 | Inhibition of Nitrite Formation from Hydroxylammonium-Chloride:A Simple Assay for Superoxide Dismutase显示文摘 | ELSTNER E F HEUPEL A | 1976 | Analytical Biochemistry1976，70，2： | 1 |
| 5 | Anesthesia for orthopedic surgery in Pallister-Killian syndrome显示文摘 | Jana Knab Erhart W Heupel Daniel Steinmann | 2008 | Paediatric anaesthesia2008，18，7： | 1 |
| 6 | Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo 显示文摘 | HEUPEL W M EFTHYMIADIS A SCHLEGEL N | 2009 | J Cell Sci2009，122，10： | 1 |
| 7 | Micro-satellite and mitochondrial DNA analyses of the genetic structure of blacktip shark (Carcharhinus limbatus) nurseries in the northwestern Atlantic,Gulf of Mexico,and Caribbean Sea显示文摘 | KEENEY D B HEUPEL M R HUETER R E | 2005 | Mol Ecol2005，14，： | 1 |
| 8 | Inhibition of nitrite formation from hydroxylammoniumchloride: a simple assay for superoxide dismutase显示文摘 | Elstner EF Heupel A | 1976 | Anal Biochem1976，70，2： | 1 |
| 9 | Inhibition of nitrite formation from hydroxylam moniumcloride; a simple assay for superoxide dismutase显示文摘 | Elstner EF Heupel a | 1976 | Ana biochem1976，70，： | 1 |
| 10 | The beta subunit of tomato fruit polygalacturonase isoenzyme 1: isolation, characterization, and identification of unique structural features显示文摘 | Zheng L Heupel R C Dellapenna D | 1992 | Plant Cell1992，4，2： | 1 |
| 11 | Inhibition of Nitrite Formation From Hydroxylammonium-Chloride:A Simple Assay for Superoxide Dismutase显示文摘 | ELSTNER E F HEUPEL A | 1976 | Analytical Biochemistry1976，70，2： | 1 |
| 12 | The beta subunit of tomato fruit polygalacturonase isoenzyme 1:isolation,characterization,and identification of unique structural features显示文摘 | Zheng L Heupel RC DellaPenna D | 1992 | Plant Cell1992，4，： | 1 |
| 13 | Inhibition of nitrite formation from hydroxylammonium chloride: a simple assay for superoxide dismutase 显示文摘 | Elstner E F Heupel A | 1976 | Anal Biochem1976，，70： | 1 |
| 14 | Inhibition of nitrite formation from hydroxy lammoniumch-loride: a simple assay for superoxide dismutase 显示文摘 | Elstaer E F Heupel A | 1976 | Anal Bioehem1976，，70： | 1 |
| 15 | Pemphigus valgaris IgG cause loss of desmoglein-mediated adhesion and keratinocyte dissociation independent of epidermal growth factor receptor显示文摘 | Heupel W'M Engerer P Schmidt E | 2009 | Am J Pathol2009，174，2： | 1 |
| 16 | Inhibition of nitrite formation from hydroxylammoniumchloride: a simple assay for superoxide dis- mutase显示文摘 | Elstner E Heupel A | 1976 | Analytical Biochemistry1976，70，2： | 1 |
| 17 | Inhibition of nitrite formation from hydroxylaminonium-chloride: a simple assay for super- oxide dismutase 显示文摘 | ELSTNER E F HEUPEL A | 1976 | Analytical Biochemistry1976，70，2： | 1 |
| 18 | Inhibition of nitrite formation from hydroxylammoniumchloride: A impleassayforsuperoxidedismutase 显示文摘 | Elstner EF Heupel A | 1996 | Annab Biochem1996，70，5： | 1 |
| 19 | Inhibition of nitrite formation from hydroxylammoniumch-loride:a simple assay for superoxide dismutase显示文摘 | Elstner EF Heupel A 1976 | 1976 | Anal Biochem1976，70，： | 1 |
| 20 | Inhibition of nitrite formation fromhydroxylammonium chloride: a simply assay for superoxidedismutase显示文摘 | Elstner E F Heupel A | 1976 | Analytical Biochemistry1976，70，： | 1 |
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