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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Groucho is required for Drosophila neurogenesis,segmentation,and sex determination and interacts directly with hairy-related bHLH proteins显示文摘 | Paroush Z Finley RL Jr Kidd T | 1994 | Cell1994，79，5： | 1 |
| 3 | Heat transfer and pressure drop for nitrogen flowing in tubes containing twisted-tapes显示文摘 | KIDD JR G C | 1969 | AICh E J1969，15，4： | 1 |
| 4 | Candidate SNPs for a universal individual identification panel显示文摘 | Pakstis AJ Speed WC Kidd JR | 2007 | Hum Genet2007，121，34： | 1 |
| 5 | Comparisons of male and female broiler responses to dietary threonine from 42 to 56 days of age显示文摘 | Dozier W A Moran Jr E T Kidd M T | 2001 | J ApplPoult Res2001，10，： | 1 |
| 6 | Drift, admixture, and selection in human evalution: a study with DNA palymorphisms显示文摘 | Bowcock AM Kidd JR Mountain JL | 1991 | Proc Natl Acad Sci U S A1991，88，3： | 1 |
| 7 | Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate显示文摘 | Loughran T P Jr Kidd P G Starkebaum G | 1994 | Blood1994，84，7： | 1 |
| 8 | α-Galactosidase enzyme supplementation to corn and soybean meal broiler diets 显示文摘 | Kidd M T Morgan G W Zumwalt Jr C D | 2001 | J Appl Poult Res2001，10，： | 1 |
| 9 | Groueho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins 显示文摘 | Paroush Z Finley RL Jr Kidd T | 1994 | Cell1994，79，5： | 1 |
| 10 | The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus显示文摘 | Chang FM Kidd JR Livak KJ | 1996 | Hum Genet1996，98，： | 1 |
| 11 | Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins 显示文摘 | Paroush Z Finley RL Jr Kidd T | 1994 | Cell1994，79，5： | 1 |
| 12 | Groucho is required for Drosophila neurogenesis,segmentation,and sex determination and interacts directly with hairy-related bHLH proteins显示文摘 | Paroush Z Finley R L Jr Kidd T | 1994 | Cell1994，79，5： | 1 |
| 13 | The world-wide distribution of allele frequencies at human dopamine 4 receptor locus1显示文摘 | Chang FM Kidd JR Livak KJ | 1996 | Hum Genet1996，98，1： | 1 |
| 14 | Bitter receptor gene (TAS2R38),6-n-Propylthiouracil (PROP) bitterness and alcohol intake显示文摘 | Duffy VB Davidson AC Kidd JR Kidd KK Speed WC Pakstis AJ Reed DR Snyder DJ Bartoshuk LM | | 0，，： | 1 |
| 15 | Candidate SNPs for a universal individual identification panel 显示文摘 | Pakstis AJ Speed WC Kidd JR | 2007 | Hum Genet2007，121，34： | 1 |
| 16 | ALFRED: an allele frequency database for diverse population and DNA polymorphisms an update 显示文摘 | Osier MV Cheung KH Kidd JR | 2001 | Nucleid Acids Res2001，29，1： | 1 |
| 17 | The phototumorigenic fluoroquinolone, lomefloxacin, photosensitises p53 accumulation and transcriptional activity in human skin cells 显示文摘 | KIDD S MEUNIER JR TRAYNOR NJ | 2000 | I Photochem Photobiol B2000，，： | 1 |
| 18 | Groueho is re- quired fbr Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related b- HIgH proteins显示文摘 | Paroush Z Finley R L Jr Kidd T | 1994 | Cell1994，79，5： | 1 |
| 19 | Genetic landscape of Eurasia and “admixture” in Uyghurs显示文摘 | Li H Cho K Kidd JR | 2009 | Am J Hum Genet2009，85，6： | 1 |
| 20 | Candidate SNPs for a universal individual identification panel显示文摘 | Pakstis AJ Speed WC Kidd JR | 2007 | Hum Genet2007，121，34： | 1 |
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