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| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Feasible bioremediation through arbuscular mycorrhizal fungi imparting heavy metal tolerance: A retrospective显示文摘 | KHADE S W ADHOLEYA A | 2007 | Biorcmediation Journal2007，11，1： | 1 |
| 3 | Importance of reciprocal leads in acute myocardial infarction显示文摘 | Parale G P Kulkarni P M Khade S K | 2004 | J As- soc Physicians India2004，52，： | 1 |
| 4 | Rotation-invariant similarity in time series using bag-of-patterns representation显示文摘 | Lin J Khade R Li Y | 2012 | Journal of Intelligent Informa- tion Systems2012，39，2： | 1 |
| 5 | Antibiotic conjugated fluorescent car- bon dots as a theranostic agent for controlled drug release, bioimaging, and enhanced antimicrobial activity 显示文摘 | Thakur M Pandey S Mewada A Patil V Khade M Goshi E Sharon M | 2014 | Jour- nal of Drug Delivery2014，2014，28： | 1 |
| 6 | Antibiotic Conjugated Fluorescent Carbon Dots as a Theranostic Agent for Controlled Drug Release, Bioimaging, and Enhanced Antimicrobial Activity显示文摘 | Mukeshchand Thakur Sunil Pandey Ashmi Mewada Vaibhav Patil Monika Khade Ekta Goshi Madhuri Sharon Roberta Cavalli | 2014 | Journal of Drug Delivery2014，，： | 1 |
| 7 | 7-Methoxy-3-nitro-2-naphthalene-methanol: a new phototrigger for caging applications]显示文摘 | Singh A K Khade P K | 2011 | Tetrahedron Letters2011，52，38： | 1 |
| 8 | 3D Chaotic Functions for Image Encryption显示文摘 | Khade P N Narnaware M | 2012 | International Journal of Computer Science Issues2012，9，3： | 1 |
| 9 | Synthesis and photochemical properties of nitro -naphthyl chromophore and the corresponding immunoglobulin bioconjugate显示文摘 | Singh AK Khade PK | 2002 | Bio Conjugate Chem2002，13，6： | 1 |
| 10 | New empirical friction loss correlation for flare fluids in CT显示文摘 | Khade S D Shah S N | 2002 | SPE 74810 - MS2002，，： | 1 |
| 11 | Synthesis and photochemical properties of nitro-naphthyl chromophore and the corresponding immunoglobulin bioconjugate显示文摘 | Khade PK | 2002 | Bio Conjugate Chem2002，13，6： | 1 |
| 12 | Dentiscutata nigerita-a new species of arbuscular my- corrhizal fungi from India显示文摘 | Khade S W | 2010 | Mycosphere2010，1，3： | 1 |
| 13 | 澳门摩珀斯酒店显示文摘澳门新濠天地旗舰酒店摩珀斯酒店于2018年6月15日开业。澳门作为亚洲最受欢迎的娱乐目的地,2017年接待了超过3,200万名游客,并且游客数量连年增加。新濠天地位于澳门路氹城,是一个集赌场、戏院、购物区、餐厅及酒店于一体的综合度假胜地。扎哈·哈迪德建筑事务所于2012年接受委托建造该酒店,当时项目场地上有一座已经打好地基但没有后续进展的塔楼。建筑师以中国传统玉雕丰富而流畅的造型为灵感,用创新的工程技术和流动性的方式将建筑的公共空间和私密空间融合在一起。建筑形体被构想为一个垂直挤压的矩形体量,建筑中部的一系列虚空间仿佛城市的窗口,将酒店内部的公共空间与城市连接起来,形成具有雕塑感的独特空间形式。 | Zaha Hadid Patrik Schumacher Viviana Muscettola Michele Pasca di Magliano Michele Salvi Bianca Cheung Maria Loreto Flores Clara Martins Miron Mutyaba Milind Khade Pierandrea Angius Massimo Napoleoni Stefa no lacopini Davide Del Giudice Luciano Letteriello Luis Migue Samanez Cyril Manyara Alvin Triestanto Muhammed Shameel Goswin Rothenthal Santiago Fernandez-Achury Vahid Eshraghi Melika Aljukic Virgile Simon Bertrand(摄) Ivan Dupont(摄) 无 | 2020 | 建筑实践2020，3，9： | 0 |
| 14 | Iris Liveness Detection Using Fragmental Energy of Haar Transformed Iris Images Using Ensemble of Machine Learning Classifiers显示文摘Contactless verification is possible with iris biometric identification,which helps prevent infections like COVID-19 from spreading.Biometric systems have grown unsteady and dangerous as a result of spoofing assaults employing contact lenses,replayed the video,and print attacks.The work demonstrates an iris liveness detection approach by utilizing fragmental coefficients of Haar transformed Iris images as signatures to prevent spoofing attacks for the very first time in the identification of iris liveness.Seven assorted feature creation ways are studied in the presented solutions,and these created features are explored for the training of eight distinct machine learning classifiers and ensembles.The predicted iris liveness identification variants are evaluated using recall,F-measure,precision,accuracy,APCER,BPCER,and ACER.Three standard datasets were used in the investigation.The main contribution of our study is achieving a good accuracy of 99.18%with a smaller feature vector.The fragmental coefficients of Haar transformed iris image of size 8∗8 utilizing random forest algorithm showed superior iris liveness detection with reduced featured vector size(64 features).Random forest gave 99.18%accuracy.Additionally,conduct an extensive experiment on cross datasets for detailed analysis.The results of our experiments showthat the iris biometric template is decreased in size tomake the proposed framework suitable for algorithmic verification in real-time environments and settings. | Smita Khade Shilpa Gite Sudeep D.Thepade Biswajeet Pradhan Abdullah Alamri | 2023 | Computer Modeling in Engineering & Sciences2023，，7： | 0 |
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