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| 1 | Combination could be another tool for bowel preparation?显示文摘Optimal bowel preparation increases the cecal intubation rate and detection of neoplastic lesions while decreasing the procedural time and procedural-related complications. Although high-volume polyethylene glycol(PEG) solution is the most frequently used preparation for bowel cleansing, patients are often unwilling to take PEG solution due to its large volume, poor palatability, and high incidence of adverse events, such as abdominal bloating and nausea. Other purgatives include osmotic agents(e.g., sodium phosphate, magnesium citrate, and sodium sulfate), stimulant agents(e.g., senna, bisacodyl, and sodium picosulfate), and prokinetic agents(e.g., cisapride, mosapride, and itopride). A combination of PEG with an osmotic, stimulant, or prokinetic agent could effectively reduce the PEG solution volume and increase patients' adherence. Some such solutions have been found in several published studies to not be inferior to PEG alone in terms of bowel cleansing quality. Although combination methods showed similar efficacy and safety, the value of these studies is limited by shortcomings in study design. New effective and well-tolerated combination preparations are required, in addition to rigorous new validated studies. | Jae Seung Soh Kyung-Jo Kim | 2016 | World Journal of Gastroenterology2016，22，10： | 7 |
| 2 | 肠镜前肠道准备方法研究近况显示文摘肠镜检查是肠道黏膜病变的一项重要诊断方法 ,肠道准备的优劣直接影响了检查的结果甚至镜下治疗的成败。临床试验常在甘露醇、硫酸镁、复方聚乙二醇电解质散、磷酸钠口服溶液、人工灌肠、仪器灌肠等常用泻药或通便疗法的浓度、用药时机、经济性、适用人群中进行对比研究,不同国家及区域的研究结果不尽相同。同时针对长期便秘的人群来说,如何提前做好准备,更有效地给予药物及饮食干预,缩短便秘患者的肠道准备时间,提高肠道准备清洁度,且不增加不良反应,是临床研究的难点及热点。 | 许珊珊 黎军 | 2014 | 医学综述2014，20，21： | 6 |
| 3 | 西甲硅油在克罗恩病结肠镜检查和治疗中的应用分析显示文摘目的分析西甲硅油在克罗恩病结肠镜检查和治疗中的应用效果。方法连续选择96例克罗恩病便秘患者,随机分为对照组[单用复方聚乙二醇电解质散(PEG-ELS)]48例和观察组(PEG-ELS联合西甲硅油)48例,所有患者均加用莫沙必利,对比观察效果。结果观察组的肠道清洁比例高于对照组,结肠内气泡存在程度低于对照组,差异有统计学意义(P<0.05),视野清晰A、B级显著增多。观察组患者腹胀程度显著轻于对照组,差异有统计学意义(P<0.05),无腹胀比例增多,中、重度腹胀比例减少。观察组显示的病变数目和长度较多,选择治疗的患者中观察组成功率高于对照组,差异有统计学意义(P<0.05)。结论西甲硅油可明显提高克罗恩病便秘患者结肠镜检查和治疗的应用效果。 | 王屹然 陈光侠 费素娟 | 2016 | 新医学2016，47，8： | 5 |
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