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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | Diagnosing, planning and evaluating osteochondral ankle defects with imaging modalities显示文摘This current concepts review outlines the role of diffe-rent imaging modalities in the diagnosis, preoperative planning, and follow-up of osteochondral ankle defects. An osteochondral ankle defect involves the articular cartilage and subchondral bone(usually of the talus) and is mostly caused by an ankle supination trauma. Conventional radiographs are useful as an initial imaging tool in the diagnostic process, but have only moderate sensitivity for the detection of osteochondral defects. Computed tomography(CT) and magnetic resonance imaging(MRI) are more accurate imaging modalities. Recently, ultrasonography and single photon emission CT have been described for the evaluation of osteochondral talar defects. CT is the most valuable modality for assessing the exact location and size of bony lesions. Cartilage and subchondral bone damage can be visualized using MRI, but the defect size tends to be overestimated due to bone edema. CT with the ankle in full plantar flexion has been shown a reliable tool for preoperative planning of the surgical approach. Postoperative imaging is useful for objective assessment of repair tissue or degenerative changes of the ankle joint. Plain radiography, CT and MRI have been used in outcome studies, and different scoring systems are available. | Christiaan JA van Bergen Rogier M Gerards Kim TM Opdam Maaike P Terra Gino MMJ Kerkhoffs | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 3 | Effect of driving piles in soft clay显示文摘 | Cununings A E Kerkhoff G | 1950 | Trans ASCE1950，115，： | 1 |
| 4 | Correction of lateral tibial plateau depression and valgus nkalunion of the proximal tibia 显示文摘 | Marti RK Kerkhoffs GM Rademakers MV | | Oper Orthop T aumatol0，19，10： | 1 |
| 5 | The influence ofobesity on the complication rate and outcome of total knee arthroplasty:a meta-analysis and systematic literature re- view显示文摘 | Kerkhoffs GM Servien E Dunn W | 2012 | J Bone Joint Surg Am2012，94，20： | 1 |
| 6 | Development of a polymerase chain reaction for the detection of Anguillid herpesvirus DNA in eels based on the herpesviros DNA polymerase gene 显示文摘 | RIJSEWIJK F PRITZ-VERSCHUREN S KERKHOFF S | 2005 | J Virol Methods2005，124，12： | 1 |
| 7 | Syndesmosis and deltoid ligament injuries in the athlete 显示文摘 | McCollum GA van den Bekerom MP Kerkhoffs GM | 2013 | Knee Surg Sports Traumatol Arthrosc2013，21，6： | 1 |
| 8 | Two-dimensional and three-dimensional computed tomography for the classification and characterisation of tibial plateau fractures显示文摘 | Job N. Doornberg Maarten V. Rademakers Michel P. van den Bekerom Gino M. Kerkhoffs Jaimo Ahn E.Ph. Steller Peter Kloen | 2011 | Injury2011，，12： | 1 |
| 9 | Testing of Microelectronic-biofluidic Systems显示文摘 | Kerkhoff H G | 2007 | IEEE Design Test of Computers2007，24，1： | 1 |
| 10 | Peripheral nerve lesions:the neuropharmacological outlook显示文摘 | Kerkhoff H Jennekens FG | 1993 | Clin Neurol Neurosurg1993，，： | 1 |
| 11 | Repetitive optokinetic stimutation induces lasting recovery from visual neglect显示文摘 | Kerkhoff C Keller I Ritter V | 2006 | Restorative Neurology and Neuroscience2006，24，46： | 1 |
| 12 | Functional treat- ment after surgical repair of acute Achilles tendon rupture: wrap vs walking cast 显示文摘 | Kerkhoffs GM Struijs PA Raaymakers EL | 2002 | Arch Orthop Trauma Surg2002，122，： | 1 |
| 13 | Long-term outcome after 1822 operatively treated ankle frac-tures: a systematic review of the literature显示文摘 | Stufkens S A van den Bekerom M P Kerkhoffs G Mt | 2011 | Injury2011，42，2： | 1 |
| 14 | Basic fibroblast growth factor immunoreactivity in the peripheral motor system of the rat显示文摘 | Sherif M. Hassan Henk Kerkhoff Dirk Troost Henk Veldman Frans G. I. Jennekens | 1994 | Acta Neuropathologica1994，，4： | 1 |
| 15 | Plasticily in spatial neglect: recovery and rehabilitalion显示文摘 | Kerkhoff G Rossetti Y | 2006 | Restorative Neurology and Neuroscience2006，24，46： | 1 |
| 16 | Long-term outcome after 1822 operatively treated ankle fractures:a systematic review of the literature显示文摘 | Stufkens SA van den Bekerom MP Kerkhoffs GM | 2011 | Injury2011，42，2： | 1 |
| 17 | Combined intra-articular and varus opening wedge osteotomy for lateral depression and valgus malunion of the proximal part of the tibia显示文摘 | Kerkhoffs GM Rademakers MV Altena M | 2008 | J Bone Joint Surg Am2008，90，6： | 1 |
| 18 | Plant allometry, stoichiometry and the temperature - dependence of primary productivity显示文摘 | KERKHOFF A J ENQUIST B J ELSER J J | 2005 | Global Ecology and Biogeography2005，14，6： | 1 |
| 19 | Biological stoichiometry of plant production: metabolism, scaling and ecological response to global change显示文摘 | ELSER J J FAGAN W F KERKHOFF A J | 2010 | New Phytologist2010，186，3： | 1 |
| 20 | Novel insights into the role of S 100A8/A9 in skin biology显示文摘 | Kerkhoff C Voss A Scholzen TE | 2012 | Exp Dermatol2012，21，11： | 1 |
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