5篇
您的检索式：作者名="Kenneth Burman"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy显示文摘 | Ellen D. Yorke Andrew Jackson Kenneth E. Rosenzweig Scott A. Merrick Dorota Gabrys Ennapadam S. Venkatraman Chandra M. Burman Steven A. Leibel C.Clifton Ling | 2002 | International Journal of Radiation Oncology Biology Physics2002，，2： | 1 |
| 2 | Hypothyroidism显示文摘 | Madhuri Devdhar Yasser H. Ousman Kenneth D. Burman | 2007 | Endocrinology and Metabolism Clinics of North America2007，，3： | 1 |
| 3 | Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses显示文摘BACKGROUND Immune checkpoint inhibitors(ICPi)cause various immune-related adverse events(irAE)with thyroid dysfunction as a commonly reported abnormality.There is increasing evidence showing positive association with development of irAE and survival.However,prior trials with ICPi had underrepresentation of minorities with<5%African Americans.AIM To evaluate the association between development of irAE and survival outcomes among a racially diverse patient population.METHODS Data on patients with stage IV solid malignancies treated with programmed cell death-protein 1/programmed death ligand 1 blockers between January 2013 and December 2018 across MedStar Georgetown Cancer Institute facilities were retrospectively reviewed.Patients treated with cytotoxic T-lymphocyte-associated protein 4 inhibitors were excluded.Progression free survival(PFS)and overall survival(OS)were primary endpoints and were calculated using Kaplan-Meier methods and Wilcoxon rank sum test for comparison.RESULTS Out of 293 patients who met eligibility criteria,91 pts(31%)had any grade irAE;most common AE were endocrine(40.7%)specifically TSH elevation,dermatological(23.1%)and rheumatologic(18.7%).Proportion of irAE was significantly higher in Caucasians vs African Americans(60.4%vs 30.8%),in patients with low programmed death ligand 1,lower LDH,older age,and those who had more treatment cycles with ICPi.Rate of progression was lower in patients with irAE(30.8%vs 46.0%,P=0.0140).Median PFS(5.8 vs 3.0 mo,P=0.0204)and OS(17.1 vs 7.2 mo,P<0.0001)were higher with irAE.Statistically significant difference in OS(17.1 vs 8.6 mo,P=0.0002)but not in PFS(5.8 vs 3.3 mo,P=0.0545)was noted with endocrine irAE.No differences in survival were observed among other commonly reported irAE.Differences in survival among subgroups of patients with irAE are described.CONCLUSION Development of irAE positively correlated with improved PFS and OS as reported in previous studies.To our knowledge,this is the first study observing differences in OS favoring endocrine AE and Caucasian race.These factors may be potential surrogate markers of prognosis pending replication of these results in large-scale studies. | Monica Peravali Cristiane Gomes-Lima Eshetu Tefera Mairead Baker Mamta Sherchan Saira Farid Kenneth Burman Florina Constantinescu Irina Veytsman | 2021 | World Journal of Clinical Oncology2021，12，2： | 1 |
| 4 | Treatment With Metformin Is Associated With Higher Remission Rate in Diabetic Patients With Thyroid Cancer显示文摘 | Joanna Klubo-Gwiezdzinska John Costello Aneeta Patel Andrew Bauer Kirk Jensen Mihriye Mete Kenneth D. Burman Leonard Wartofsky Vasyl Vasko | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，： | 1 |
| 5 | Clinical unity of assays for TSH Receptor antobodies显示文摘 | Kenneth D Burman MD Ray Pandian Ph D | 1998 | The Endocrinologist1998，8，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员