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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 3 | Nurturing Emergent Readers Through Readers Theater显示文摘 | Kelli Jo Kerry Moran | 2006 | Early Childhood Education Journal2006，，5： | 1 |
| 4 | Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest显示文摘在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是否具备物理休眠机制,以及这些植物是如何克服这些自然屏障的,并最终理解巴西干旱热带森林土壤种子库中种子萌发时间动态。本研究选择巴西Caatinga森林中的5种本地草本植物的种子,经过发芽前处理来验证是否存在物理休眠。连续4年在雨季和旱季收集土壤样品,并监测这些草本植物种子在温室中的萌发动态。利用广义线性模型验证种子萌发和出苗率的差异。研究结果表明Caatinga森林中的草本植物种子存在着物理休眠和非物理休眠;而且草本植物从土壤种子库中出苗的种内和种间存在着年份和季节的差异。对于多年生草本植物,不同季节和年份频繁出现不出苗的现象,这可能与物理休眠机制和克服种皮障碍所需的环境条件有关。在这些物种中,种子的二态性和休眠可能给它们的生存带来额外的优势。此外,在一年生植物中出现中等水平的物理休眠可能是对降雨不可预测性的进化调整。相比之下,我们发现没有休眠的一年生草本植物对季节和年际气候变化更敏感,这可以从土壤种子库中其出苗率的增加和显著减少得到证明。这些通过进化获得的种子休眠差异有利于那些分布在气候变化无常的半干旱地区草本植物种群的建立。 | José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana Ramos de Andrade Elcida de Lima Araújo | 2020 | Journal of Plant Ecology2020，13，3： | 1 |
| 5 | Features of In Vitro Ultrasound Biomicroscopic Imaging and Colonoscopy for Detection of Colon Tumor in Mice显示文摘 | Kelly Z. Alves Helena L. Borges Rossana C. Soletti Anália L.P. Viana Lorena I. Petrella M?nica Soldan Vera L. Chagas Alberto Schanaider Jo?o C. Machado | 2011 | Ultrasound in Medicine & Biology2011，，12： | 1 |
| 6 | Neonatal spongioform myelinopathy after restricted application of hexachlorophane skin disinfectant显示文摘 | Anderson JM Cockburn F Forfar JO Harkness RA Kelly RW Kilshaw B | 1981 | J Clin Pathol1981，34，1： | 1 |
| 7 | Right hemicolectomy: mechanical bowel preparation is not required 显示文摘 | Jansen JO O'Kelly TJ Krukowski ZH | 2002 | J R Coil Surg Edinb2002，47，3： | 1 |
| 8 | Cardiorespiratory fitness and walking ability in subacute stroke patients 显示文摘 | Kelly JO Kilbreath SL Davis GM | 2003 | Arch Phys Med Rehabil2003，84，12： | 1 |
| 9 | A socioeconomic and natural vulnerability index for oil spills in an Amazonian harbor: A case study using GIS and remote sensing显示文摘 | Milena Marília Nogueira de Andrade Claudio Fabian Szlafsztein Pedro Walfir M. Souza-Filho Adrilayne dos Reis Araújo Monique Kelly Tavares Gomes | 2010 | Journal of Environmental Management2010，，10： | 1 |
| 10 | Cardiores piratory fitness and walking ability in subacute stroke patients显示文摘 | Kelly JO Kilbreath SL Davis GM | 2003 | Arch Phys Med Rehabil2003，84，12： | 1 |
| 11 | Outcome After Curative Resection for Locally Recurrent Rectal Cancer显示文摘 | Isabelle Bedrosian M.D. Geoffrey Giacco M.S. Lee Pederson M.D. Miguel A. Rodriguez-Bigas M.D. Barry Feig M.D. Kelly K. Hunt M.D. Lee Ellis M.D. Steven A. Curley M.D. Jean Nicolas Vauthey M.D. Marc Delclos M.D. Christopher H. Crane M.D. Nora Janjan M.D. Jo | 2006 | Diseases of the Colon & Rectum2006，，2： | 1 |
| 12 | Epidermal growth factor stimulates synthesis and secretion of mucus glycoproteins in human gastric mucosa显示文摘 | Kelly SM Hunter JO | 1990 | Clin Sci1990，79，： | 1 |
| 13 | Wool-derived keratinstimulates human keratinocyte migration and types IV andVH collagen expression显示文摘 | Tang L Sierra JO Kelly R | 2012 | Exp Dermatol2012，21，6： | 1 |
| 14 | Right hemicolectomy: mechanical bowel preparation is not required显示文摘 | Jansen JO O'Kelly TJ Krukowski ZH | 2002 | JR Coil Surg Edinb2002，47，3： | 1 |
| 15 | EGF stimulates synthesis and secretion of mucus glycoproteins in human gastric mucosa显示文摘 | Kelly SM Hunter JO | 1990 | Clin Sci1990，79，5： | 1 |
| 16 | EGF stimulates synthesis and secretion of mucus glycoproteins in human gastric mucosa显示文摘 | Kelly SM Hunter JO | 1990 | Clin Sci1990，79，5： | 1 |
| 17 | Gallbladder perforation due to endoscopic sleeve gastroplasty: A case report and review of literature显示文摘BACKGROUND The healthcare impact of obesity is enormous,and there have been calls for new approaches to containing the epidemic worldwide.Minimally invasive procedures have become more popular,with one of the most widely used being endoscopic sleeve gastroplasty(ESG).Although major adverse events after ESG are rare,some can cause considerable mortality.To our knowledge,there has been no previous report of biliary ascites after ESG.CASE SUMMARY A 48-year-old female with obesity refractory to lifestyle changes and prior gastric balloon placement underwent uncomplicated ESG and was discharged on the following day.On postoperative day 3,she developed abdominal pain,which led to an emergency department visit the following day.She was readmitted to the hospital,with poor general health status and signs of peritoneal irritation.Computed tomography imaging showed fluid in the abdominal cavity.Laparoscopy revealed biliary ascites and showed that the gallbladder was sutured to the gastric wall.The patient underwent cholecystectomy and lavage of the abdominal cavity and was admitted to the intensive care unit postoperatively.After 7 d of antibiotic therapy and 20 d of hospitalization,she was discharged.Fortunately,6 mo later,she presented in excellent general condition and with a 20.2%weight loss.CONCLUSION ESG is a safe procedure.However,adverse events can still occur,and precautions should be taken by the endoscopist.In general,patient position,depth of tissue acquisition,location of stitch placement,and endoscopist experience are all important factors to consider to mitigate procedural risk. | João de Siqueira Neto Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Sérgio Alexandre Barrichello Kelly E Harthorn Christopher C Thompson | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，3： | 1 |
| 18 | EGF stimulates synthesis and secretion of mucus glycol proteins in human gastric mucosa 显示文摘 | Kelly SM Hunter JO | 1990 | Clin Sci1990，79，5： | 1 |
| 19 | Decreased Salivary epidermal growth factor in rheumatoid disease: apossible mechanism for increased susceptibility to gastric laceration 显示文摘 | Kelly SM Crampton J Hunter JO | 1990 | BMJ1990，301，6749： | 1 |
| 20 | Cardiorespiratory fitness and walking ability in subaeute stroke patients显示文摘 | Kelly JO Kilbreath SL Davis GM | 2003 | Arch Phys Med Rehabil2003，84，12： | 1 |
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