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| 1 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 2 | The influence of temperature on rare earth flotation with naphthyl hydroxamic acid显示文摘The influence of temperature on the complex process of Bayan Obo rare earth(RE) ore flotation with a collector of naphthyl hydroxamic acid(LF8#) was investigated. Industrial test data shows that the grade and recovery of RE increase with the temperature. However, the proportion of bastnaesite in the bulk concentrate increases as the RE grade improves. Adsorption mechanism of LF8# on the surfaces of bastnaesite and monazite were confirmed via zeta potential, UV/Vis Spectrophotometer(UV/Vis), Fourier transform infrared(FTIR), and X-ray photoelectron spectroscopy analyses(XPS). Although the results indicate that the total amount of the LF8# adsorption on the surface of bastnaesite and monazite decreases with increasing the temperature, the amount of stable adsorbed predominance of characteristic bonds(-C(=O)N-) from LF8# uptake on bastnaesite surfaces increases significantly at high temperatures. This conclusion indicates that the adsorption stability increases with increasing the temperature.For monazite, the amount of characteristic elements C and N in LF8# does not increase as the temperature increases on the mineral surface, but the proportion of characteristic bonds increases, which shows that the adsorption stability of LF8# on the surface of monazite also increases, but it is not as significant as bastnaesite, which may be one of the reasons that the floatability of bastnaesite is better than those of monazite. Pulp dispersion results show that the temperature improve the dispersions of both the gangue and RE minerals. This improved the flotation selectivity so that it favored RE minerals. The calculated bubble size distribution confirms that higher temperatures generate smaller bubbles, thereby increasing the bubble-particle collision probability and the recovery of RE minerals. | Mei Li Kai Gao Dongliang Zhang Haijun Duan Linlin Ma Lan Huang | 2018 | Journal of Rare Earths2018，36，1： | 13 |
| 3 | Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions显示文摘MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve repair.However,nerve injuries in the CNS also involve other cell types,such as microglia and astrocytes.Herein,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo.We found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte activation.In addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro.Collectively,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.All experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016. | Lan Huong Nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew | 2020 | Neural Regeneration Research2020，15，4： | 11 |
| 4 | Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice显示文摘Tumor vascular normalization has been proposed as a therapeutic strategy for malignant neoplasms, which can also interpret the synergistic effect of anti-angiogenesis agents combined with chemotherapy. Apatinib (Apa), a highly selective VEGFR2 inhibitor, attracts much attentions due to its encouraging anticancer activity, especially in the clinical trials of combined treatment. In this study, we investigated whether Apa could promote vascular normalization in tumor in a certain time window. Mice bearing LoVo colon cancer xenograft were orally administrated Apa (150 mg kg^-1 per day) for 5, 7, 10, or 12 days. Apa significantly inhibited tumor growth and decreased the microvessel density. Using multi-photon microscopy and electron microscopy, we found that Apa improved tumor vessel morphology by pruning distorted vessel branches and decreased the gap between endothelial cells after a 7-day treatment. Furthermore, Apa decreased vessel leakage and in creased pericyte coverage on vascular en dothelial cells, suggesting that tumor vessels were more mature and integrated. The intratumoral distribution of adriamycin (ADR) in Apa group was improved from day 7 to 10 without change in plasma drug concen tration. Tumor blood perfusion was also in creased in this window, and the expression of hypoxia induced factor 1a was downregulated, suggesting the effect of Apa on alleviating tumor hypoxic micro-e nvironme nt. In conclusi on, Apa may improve the effective perfusi on of tumor vessels and in crease the intratumoral distribution of ADR in a certain time window via normalizing tumor vessels. This normalization window (7 to 10 days of treatment) may con tribute to develop a regime n of combi ned medication in clinic use of Apa. | Kai Zhou Jing-wei Zhang Qi-zhi Wang Wen-yue Liu Jia-li Liu Lan Yao Ming-min Cai Sui-ying Ni Qing-yun Cai Guang-ji Wang Fang Zhou | 2019 | Acta Pharmacologica Sinica2019，40，4： | 10 |
| 5 | Can ultrasound predict the severity of acute pancreatitis early by observing acute fluid collection?显示文摘INTRODUCTIONThe spectrum of acute pancreatitis (AP) ranges from a mild spontaneously resolved disorder to severe disease with mortality up to 20%-48.4%[1-3]. sAP is defined as the AP with organ failure and /or local complications which developed form acute fluid collection (AFC) including necrosis ,abscess , pseudocyst formation into or around the pancreas [4]. | Yan Luo1 Chao Xin Yuan1 Yu Lan Peng1 Pei Lin Wei1 Zhao Da Zhang2 Jun Ming Jiang3 Lin Dai1 Yun Kai Hu1 1Ultrasound Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China2Surgery Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China3Tranditional Chinese Medicine, Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China | 2001 | World Journal of Gastroenterology2001，7，2： | 8 |
| 6 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 7 | Medical expenditure for esophageal cancer in China:a 10-year multicenter retrospective survey(2002-2011)显示文摘Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China. For each esophageal cancer patient diagnosed between 2002 and 2011, clinical information and expense data were extracted by using structured questionnaires. All expense data were reported in Chinese Yuan(CNY; 1 CNY = 0.155 USD) based on the2011 value and inflated using the year-specific health care consumer price index for China.Results: A total of 14,967 esophageal cancer patients were included in the analysis. It was estimated that the overall average expenditure per patient was 38,666 CNY, and an average annual increase of 6.27% was observed from 2002(25,111 CNY) to 2011(46,124 CNY). The average expenditures were 34,460 CNY for stage Ⅰ,39,302 CNY for stage Ⅱ,40,353 CNY for stage Ⅲ, and 37,432 CNY for stage IV diseases(P < 0.01). The expenditure also differed by the therapy type, which was 38,492 CNY for surgery, 27,933 CNY for radiotherapy, and 27,805 CNY for chemotherapy(P < 0.05).Drugs contributed to 45.02% of the overall expenditure.Conclusions: These conservative estimates suggested that medical expenditures for esophageal cancer in China substantially increased in the last 10 years, treatment for early-stage esophageal cancer costs less than that for advanced cases, and spending on drugs continued to account for a considerable proportion of the overall expenditure. | Lan-Wei Guo Hui-Yao Huang Ju-Fang Shi Li-Hong Lv Ya-Na Bai A-Yan Mao Xian-Zhen Liao Guo-Xiang Liu Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Jin-Yi Zhou Ji-Yong Gong Qi Zhou Lin Zhu Yu-Qin Liu Bing-Bing Song Ling-Bin Du Xiao-Jing Xing Pei-An Lou Xiao-Hua Sun Xiao Qi Shou-Ling Wu Rong Cao Li Lan Ying Ren Kai Zhang Jie He Jian.Gong Zhang Min Dai | 2017 | Chinese Journal of Cancer2017，36，11： | 7 |
| 8 | ABA Signaling in Guard Cells Entails a Dynamic Protein-Protein Interaction Relay from the PYL-RCAR Family Receptors to Ion Channels显示文摘植物荷尔蒙 abscisic 酸(骆驼毛的织物) 用作象干旱那样的环境压力的一个综合者由在警卫房间调整特定的离子隧道触发有气孔的闭合。我们以前报导了那 SLAC1,为有气孔的闭合要求的一条外面的阴离子隧道,经由包含表明部件,包括的蛋白质磷酸酶 2C 成员和 SnRK2 类型 kinase (OST1 ) 的骆驼毛的织物的可逆蛋白质 phosphorylation 事件被调整。在这研究,我们重新组成从 PYL/RCAR-type 受体作为一个 proteinprotein 相互作用继电器表明小径的 ABA 到 PP2CSnRK2 phosphatasekinase 对,到离子隧道 SLAC1。骆驼毛的织物受体交往了与并且对 SnRK2 类型 kinase 禁止了 PP2C 磷酸酶活动,导致减少的警卫房间 turgor 和有气孔的闭合,释放活跃 SnRK2 kinase phosphorylate,并且激活 SLAC1 隧道。二混血儿的酵母和双分子的荧光互补试金被用来在小径在部件之中验证相互作用。这些生物化学的试金由他们的相互作用搭挡表明了磷酸酶和 kinases 的活动修正。SLAC1 隧道活动为发信号的小径的力量被用作端点读出,取决于表明部件的不同联合的存在。用 ABA 受体之一表明了那个变化的转基因的植物 overexpressing 的进一步的学习交往的搭挡的相对水平将变化骆驼毛的织物敏感。 | Sung Chul Lee Chae Woo Lim Wenzhi Lan Kai He Sheng Luan | 2013 | Molecular Plant2013，6，2： | 7 |
| 9 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 10 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 11 | Emerging Flexible Thermally Conductive Films:Mechanism,Fabrication,Application显示文摘Effective thermal management is quite urgent for electronics owing to their ever-growing integration degree,operation frequency and power density,and the main strategy of thermal management is to remove excess energy from electronics to outside by thermal conductive materials.Compared to the conventional thermal management materials,flexible thermally conductive films with high in-plane thermal conductivity,as emerging candidates,have aroused greater interest in the last decade,which show great potential in thermal management applications of next-generation devices.However,a comprehensive review of flexible thermally conductive films is rarely reported.Thus,we review recent advances of both intrinsic polymer films and polymer-based composite films with ultrahigh in-plane thermal conductivity,with deep understandings of heat transfer mechanism,processing methods to enhance thermal conductivity,optimization strategies to reduce interface thermal resistance and their potential applications.Lastly,challenges and opportunities for the future development of flexible thermally conductive films are also discussed. | Chang‑Ping Feng Fang Wei Kai‑Yin Sun Yan Wang Hong‑Bo Lan Hong‑Jing Shang Fa‑Zhu Ding Lu Bai Jie Yang Wei Yang | 2022 | Nano-Micro Letters2022，14，8： | 6 |
| 12 | Endovenous laser ablation of great saphenous vein with ultrasound-guided perivenous tumescence: early and midterm results显示文摘 | CHEN Jia-quan XIE Hui DENG Hao-yu YUAN Kai ZHANG Ji-wei ZHANG Hao ZHANG Lan | 2013 | Chinese Medical Journal2013，，3： | 5 |
| 13 | Diagnosis of pulmonary tuberculosis among asymptomatic HIV+ patients in Guangxi, China显示文摘尽管有高肺结核负担,在有 HIV 感染的无征状的中国病人之中的背景肺的肺结核(PTB ) 没在中国被调查。这研究被瞄准评估流行,在 Guangxi 与 HIV/AIDS 在无征状的病人之中冒险因素和 PTB 的临床的结果便于发展诊断并且治疗 strategies.Methods 在在2006年8月和2008年3月之间的 Guangxi 出席了四个 HIV 诊所的有 CD4 350 cells/l 的所有无征状的成年 感染HIV 的病人与物理检查为活跃 PTB 被评估,胸X光检查( CXR ),唾沫油迹或唾沫液体文化。数据被描述用中部( interquartile 范围, IQR )并且逻辑回归分析的 frequencies.Univariate 和 multivariate 被执行识别在 340 个无征状的题目,之中与 PTB.Results 联系的风险因素(4%) 15 与 PTB 被诊断,与 4 (27%)积极的唾沫油迹并且 8 (53%)唾沫文化积极。CXR 比唾沫油迹(25%) 和唾沫文化(67%) ,而是更低的特性(56%) 与唾沫相比涂的有更高诊断的敏感(87%)(99%) 并且文化(100%) 。在 univariate 分析,注射药用户,身体团索引(BMI ) , 18 kg/m2, CD4 50 cells/l 和外部 lymphadenopathy 的存在在仅仅外部的 lymphadenopathy 维持了的 multivariate 分析与无征状的 PTB 的增加的风险被联系统计意义(OR=7.6, 95% CI 1.4-40 ) 。有 CXR 上的否定油迹和未成年者或没有畸形的病人有在屏蔽之间的更长的间隔, TB treatment.Conclusions PTB 在这组 HIV+ 无征状的中国病人是相对普通的。诊断特别正在质问唾沫文化在哪儿是无法获得的。这些调查结果建议为 PTB 的提高的评估需要在中国与在中国和传播预防的 HIV 照顾综合在家庭和护理设备控制,特别为有与 PTB 的更高的风险联系的因素的病人。 | ZHANG Yao YU Lan TANG Zhi-rong HUANG Shao-biao ZHENG Yuan-jia MENG Zhi-hao SUN Kai WANG Li-ming Ray Y.CHEN ZHANG Fu-jie | 2010 | Chinese Medical Journal2010，，23： | 5 |
| 14 | Methyl jasmonate mediates melatonin-induced cold tolerance of grafted watermelon plants显示文摘Root–shoot communication has a critical role in plant adaptation to environmental stress.Grafting is widely applied to enhance the abiotic stress tolerance of many horticultural crop species;however,the signal transduction mechanism involved in this tolerance remains unknown.Here,we show that pumpkin-or figleaf gourd rootstock-enhanced cold tolerance of watermelon shoots is accompanied by increases in the accumulation of melatonin,methyl jasmonate(MeJA),and hydrogen peroxide(H_(2)O_(2)).Increased melatonin levels in leaves were associated with both increased melatonin in rootstocks and MeJA-induced melatonin biosynthesis in leaves of plants under cold stress.Exogenous melatonin increased the accumulation of MeJA and H_(2)O_(2) and enhanced cold tolerance,while inhibition of melatonin accumulation attenuated rootstock-induced MeJA and H_(2)O_(2) accumulation and cold tolerance.MeJA application induced H_(2)O_(2) accumulation and cold tolerance,but inhibition of JA biosynthesis abolished rootstock-or melatonin-induced H_(2)O_(2) accumulation and cold tolerance.Additionally,inhibition of H_(2)O_(2) production attenuated MeJA-induced tolerance to cold stress.Taken together,our results suggest that melatonin is involved in grafting-induced cold tolerance by inducing the accumulation of MeJA and H_(2)O_(2).MeJA subsequently increases melatonin accumulation,forming a self-amplifying feedback loop that leads to increased H_(2)O_(2) accumulation and cold tolerance.This study reveals a novel regulatory mechanism of rootstock-induced cold tolerance. | Hao Li Yanliang Guo Zhixiang Lan Kai Xu Jingjing Chang Golam Jalal Ahammed Jianxiang Ma Chunhua Wei Xian Zhang | 2021 | Horticulture Research2021，8，1： | 5 |
| 15 | Competitive adsorption of heavy metal ions on peat显示文摘The uptake capacities,and the adsorption kinetics,of copper,Cu(II),nickel,Ni(II),and cadmium,Cd(II),on peat have been studied under static conditions.The results show that the adsorption rates are rapid:equilibrium is reached in twenty minutes. The adsorption of copper,nickel and cadmium is pH dependent over the pH range from 2 to 6.The adsorption kinetics can be ex- cellently described by the Elovich kinetic equation.The adsorption isotherm fits a Langmuir model very well.The adsorption ca- pacities follow the order Cu2 +>Ni 2+>Cd 2+in single-component systems and the competitive adsorption capacities fall in the de- creasing order Cu2 +>Ni 2+>Cd 2+in multi-component systems.The adsorption capacities of these three heavy metal ions on peat are consistent with their observed competitive adsorption capacities. | LIU Zhi-rong ZHOU Li-min WEI Peng ZENG Kai WEN Chuan-xi LAN Hui-hua | 2008 | Journal of China University of Mining and Technology2008，18，2： | 4 |
| 16 | Si substituted hydroxyapatite nanorods on Ti for percutaneous implants显示文摘An ideal intraosseous transcutaneous implant should form a tight seal with soft tissue,besides a requirement of osseointegration at the bone-fixed position.Si substituted hydroxyapatite(Si-HA)nanorods releasing Si ion and simulating nanotopography of natural tissue were designed on Ti to enhance fibroblast response in vitro and biosealing with soft tissue in vivo.Si-HA nanorods were fabricated by alkali-heat treatment followed with hydrothermal treatment.The hydrothermal formation mechanism of Si-HA nanorods was explored.The surface characteristic of Si-HA nanorods was compared with pure HA nanorods.Fibroblast behaviors in vitro and skin response in vivo on different surfaces were also evaluated.The obtained results show that the substitution of Si did not significantly alter the phase component,morphology,roughness and wettability of HA,but additional Si and more Ca were released from Si-HA into medium.Comparing to pure HA nanrods and Ti substrate,Si-HA nanrods enhanced cell behaviors including proliferation,fibrotic phenotype and collagen secretion in vitro,and reduced epithelial down growth in vivo.The enhanced cell response and biosealing should be due to the releasing of Ca,Si and nanotopography of Si-HA nanorods.Si-HA nanorods can be a potential coating to accelerate skin integration for percutaneous implants in clinic. | Kai Li Yang Xue Ting Yan Lan Zhang Yong Han | 2020 | Bioactive Materials2020，5，1： | 4 |
| 17 | 盐藻β-胡萝卜素抗突变效应显示文摘目的:研究盐藻β胡萝卜素(βcarotenefromDunalielasalina,βCDS)致突变及抗突变作用.方法:用体外人淋巴细胞微核和染色体畸变检测,研究了βCDS对γ射线和丝裂霉素(Mit)诱变作用的影响.结果:βCDS1-30mg·L-1对人淋巴细胞无致突变性,但能抑制γ射线诱发的微核形成和Mit诱发的染色体畸变.当合成β胡萝卜素与天然β胡萝卜素油(βCDS成份之一)按80∶275混合后,拮抗了前者的遗传毒性,并使两者的抗突变作用得到增强. | MA GuoJian 2, XUE KaiXian, WU JianZhong (Jiangsu Institute of Cancer Research, Nanjing 210009, China) YUAN Sheng, QIN HuaiLan (Department of Biology, Nanjing Normal University, Nanjing 210097, China) | 1998 | 中国药理学报1998，19，3： | 4 |
| 18 | Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation显示文摘Numerous valuable studies on electron dynamics have focussed on the extraordinary properties of molybdenum disulfide(MoS_(2));however,most of them were confined to the level below the damage threshold.Here the electron dynamics of MoS_(2) under intense ultrafast laser irradiation was investigated by experiments and simulations.Two kinds of ablation mechanisms were revealed,which led to two distinct types of electron dynamics and final ablation morphology.At a higher fluence,the emergence of superheated liquid induced a dramatic change in the transient reflectivity and micro-honeycomb structures.At a lower fluence,the material was just removed by sublimation,and the ablation structure was relatively flat.X-ray photoelectron spectroscopic(XPS)measurements demonstrated that thermal decomposition only occurred at the higher fluence.Furthermore,a theoretical model was developed to deeply reveal the ultrafast dynamics of MoS_(2) ablation.The simulation results were in good agreement with the temporal and spatial reflectivity distribution obtained from the experiment.The electron and lattice temperature evolution was also obtained to prove the ablation mechanism.Our results revealed ultrafast dynamics of MoS_(2) above the damage threshold and are helpful for understanding the interaction mechanism between MoS_(2) and intense ultrafast lasers,as well as for MoS_(2) processing applications. | Changji Pan Lan Jiang Jingya Sun Qingsong Wang Feifei Wang Kai Wang Yongfeng Lu Yeliang Wang Liangti Qu Tianhong Cui | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 19 | Establishment of Occupational Exposure Limit for Warfarin in China显示文摘This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used aslowest observed effect | XU Jian Ning FU Zhao Hui YU Wen Lan WANG Quan Kai TAN Feng | 2013 | Biomedical and Environmental Sciences2013，26，6： | 3 |
| 20 | Transcriptome of Erysiphe necator-infected Vitispseudoreticulata leaves provides insight into grapevineresistance to powdery mildew显示文摘Powdery mildew(PM),which is caused by the pathogen Erysiphe necator(Schw.)Burr.,is the single most damaging disease of cultivated grapes(Vitis vinifera)worldwide.However,little is known about the transcriptional response of grapes to infection with PM.RNA-seq analysis was used for deep sequencing of the leaf transcriptome to study PM resistance in Chinese wild grapes(V.pseudoreticulata Baihe 35-1)to better understand the interaction between host and pathogen.Greater than 100 million(M)90-nt cDNA reads were sequenced from a cDNA library derived from PM-infected leaves.Among the sequences obtained,6541 genes were differentially expressed(DEG)and were annotated with Gene Ontology terms and by pathway enrichment.The significant categories that were identified included the following:defense,salicylic acid(SA)and jasmonic acid(JA)responses;systemic acquired resistance(SAR);hypersensitive response;plant–pathogen interaction;flavonoid biosynthesis;and plant hormone signal transduction.Various putative secretory proteins were identified,indicating potential defense responses to PMinfection.In all,318 putative R-genes and 183 putative secreted proteins were identified,including the defense-related R-genes BAK1,MRH1 and MLO3 and the defense-related secreted proteins GLP and PR5.The expression patterns of 16 genes were further illuminated by RT-qPCR.The present study identified several candidate genes and pathways that may contribute to PM resistance in grapes and illustrated that RNA-seq is a powerful tool for studying gene expression.The RT-qPCR results reveal that effective resistance responses of grapes to PM include enhancement of JA and SAR responses and accumulation of phytoalexins. | Kai Weng Zhi-Qian Li Rui-Qi Liu Lan Wang Yue-Jin Wang Yan Xu | 2014 | Horticulture Research2014，1，1： | 3 |
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