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| 1 | Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to Haemonchus contortus infection in goats显示文摘Background: Haemonchosis is a major economic problem in goat production in humid, tropical and subtropical regions. The disease is caused by an abomasal nematode, Haemonchus contortus, which is highly pathogenic in small ruminants. The aim of this study was to identifying single-nucleotide polymorphisms(SNP) that were associated with fecal egg counts(FEC) and could be used as markers to identify resistance to H. contortus in goats.Results: Ten novel variants in the CI TA, ATP2 A3, HSPA8, STAT5 B, ESYT1, and SERPING1 genes were associated with FEC in goats with a nominal significance level of P < 0.05. Two missense mutation in the exon region of the caprine CI TA gene resulted in replacement of arginine with cysteine at position 9473550(R9473550 C) and aspartic acid with glutamic acid at position 9473870(D9473870 E). Chinese goat breeds had significantly higher FEC than Bangladeshi goat breeds within their respective genotypes. Polymorphism information content(PIC), effective al ele number(Ne), and heterozygosity(He)were greatest for the STAT5 B197A > G SNP locus in al goat breeds. Pairwise coefficients of linkage disequilibrium(D′, r2)revealed complete LD(r2= 1) between significant SNP polymorphisms in CI TA and SERPING1 and strong LD(r2= 0.93 and0.98) between polymorphisms in HSPA8 and ATP2 A3, respectively. Correlation coefficient(r) between FEC and body weight(BW) was significantly positive(r = 0.56***, P < 0.001) but that between FEC and packed cel volume(PCV) was negatively significant(r =-0.47**, P < 0.01) in the total population of goats. On the other hand, correlation coefficient(r)between BW and PCV was not significant in total population of goats. Association analysis revealed that haplotypes within ATP2 A3, HSPA8, and SERPING1 were significantly associated with FEC. Quantitative real-time PCR revealed that the relative expression of m RNA was higher(P < 0.001) for resistant, compared to susceptible, groups of goats for al candidate genes except CI TA.Conclusions: This study identified SNP markers that can potential y be used in marker-assisted selection programs to develop goat breeds that are resistant to H. contortus. | Mahmuda Bilkis Bintee Alam Abdullah Ibne Omar Md.Omar Faruque David Russell Notter Kathiravan Periasamy Md.Motahar Hussain Mondal Md.Jalal Uddin Sarder Md.Shamsuddin Jianhua Cao Xiaoyong Du Zhenyang Wu Shuhong Zhao | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 2 |
| 2 | Expedited extraction of xylan from corncob by power ultrasound显示文摘Some lignocellulosic biomass like corncob contains a large amount of xylan,a valuable material for applications in food,chemical and pharmaceutical industries.Conventional extraction of xylan is a time consuming process,requiring 12 to 24 hours to complete.In this study,the efficacy of power ultrasound for reducing the extraction time and increasing the xylan yield was investigated.Two acoustic energy densities(0.18 W/mL and 0.45 W/mL)of the power ultrasound were applied to corncob for 10,20,30,and 60 min.The treated samples were steamed at 110,118 and 121℃for 30 min.At 0.45 W/mL acoustic energy density and 121℃steaming temperature,ultrasonic treatment was able to extract 39%of xylan in 43 min.In contrast,the conventional treatment was able to extract only 34%of xylan in 24 h.Power ultrasound assisted extraction reduced the processing time by 97%in addition to yield increase by 14.7%.Power ultrasound can be a potential technology for enhanced xylan extraction from corncob to result in significant processing time savings. | Wade Yang Vishnu K.Ajapur Kathiravan Krishnamurthy Hao Feng Ruijin Yang Taha M.Rababah | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 2 |
| 3 | Study on the binding of colloidal zinc oxide nanoparticles with bovine serum albumin 显示文摘 | Kathiravan A Paramaguru G Renganathan R | 2009 | Journal of Molecular Structure2009，934，： | 1 |
| 4 | TCP performance analysis for mobile Ad Hoc network using on-demand rout- ing protocols显示文摘 | Kathiravan K Thamarai S S Selvam A | 2007 | Ubiquitous Computing and Communication Journal2007，2，2： | 1 |
| 5 | Objective sperm motion analysis to assess dairy bull fertility using computer-aided system-review 显示文摘 | Kathiravan P Kalatharan J Karthikeya G | 2011 | ReprodDomest Anim2011，46，1： | 1 |
| 6 | 查看详情显示文摘 | Kathiravan A Renganathan R | | 0，，： | 1 |
| 7 | The biologyand chemistry of antifungal agents : a review 显示文摘 | KATHIRAVAN MK SALAKE AB CHOTHE AS | 2012 | Bioorg MedC/iem2012，20，19： | 1 |
| 8 | Effect of anchoring group on the photosensitization of colloidal TiO2 nanoparticles with porphyrins 显示文摘 | Kathiravan A Renganathan R | 2007 | Journal of Colloid and Interface Sci- ence2007，331，： | 1 |
| 9 | Synthesis and antihyperlipidemic activity of novel condensed 2-fluoromethylpyrimidines显示文摘 | KATHIRAVAN M K MORE K D RASKAR V K | 2013 | Medicinal Chemistry Research2013，22，： | 1 |
| 10 | Infrared heating in food processing: an overview显示文摘 | Kathiravan K Harpreet K K Soojin J | 2008 | Comprehensive Reviews in Food Science and Food Safety2008，7，1： | 1 |
| 11 | Recent advances in selective alphal-adrenoreceptor antagonists as antihypertensive agents显示文摘 | Jain K S Bariwal J B Kathiravan M K | 2008 | Bioorg Med Chem2008，16，9： | 1 |
| 12 | Spectroscopic studies on the interaction of colloidal capped CdS nanoparticles with bovine serum albumin 显示文摘 | Asha Jhonsi M Kathiravan A Renganathan R | 2009 | Colloids and Surface B : Biointerfaces2009，72，： | 1 |
| 13 | The biologyand chemistry of hyperlipidemia显示文摘 | Jain K S Kathiravan M K Somani R S | 2007 | Bioorg Med Chem2007，15，14： | 1 |
| 14 | Interaction of colloidal Ag Ti O2nanoparticles with bovine serum albumin显示文摘 | Kathiravan A Renganathan R Anandan S | 2009 | Polyhedron2009，28，1： | 1 |
| 15 | Combined High Pressure and Thermal Processing on Inactivation of Type A and Proteolytic Type Spores of Clostridium botulinum显示文摘 | Reddy N Rukma Marshall Kristin M Morrissey Travis R Loeza Viviana Patazca Eduardo Skinner Guy E Krishnamurthy Kathiravan Larkin John W | 2013 | Journal of Food Protection2013，76，8： | 1 |
| 16 | Study on the binding of colloidal zinc oxidenanoparticles with bovine serum albumin 显示文摘 | KATHIRAVAN A PARAMAGURU G RENGA- NATHAN R | 2009 | Journal of Molecular Structure2009，934，： | 1 |
| 17 | The biology and chemistry of hyperlipidemia显示文摘 | JAIN K S KATHIRAVAN M K SOMANI R S | 2007 | Bioorganic and Medicinal Chemistry2007，15，14： | 1 |
| 18 | Esti- mation of magnetic field in the solar coronal streamers through low frequency radio observations 显示文摘 | RAMESH R KATHIRAVAN C SASTRY Ch V | 2010 | The As- trophysical Journal2010，711，2： | 1 |
| 19 | Interaction of colloidal AgTiO2 nanoparticles with bovine serum albumin显示文摘 | KATHIRAVAN A RENGANATHAN R ANANDAN S | 2009 | Polyhedron2009，28，： | 1 |
| 20 | Interaction ofcolloidal Ti02 with bovine serum albumin: A uorescencequenching study 显示文摘 | KATHIRAVAN A RENGANATHAN R | 2008 | Colloids and Surfaces A : Physico-chemical and Engineering Aspects2008，324，： | 1 |
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