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| 1 | 常见呼吸道病毒分子鉴别诊断技术的建立显示文摘目的建立一种常见呼吸道感染病毒的快速检测方法,为尽早诊断、减少疾病的传播以及为临床提供良好的治疗依据。方法采用液体芯片检测技术结合靶向多重RT-PCR技术建立可以同时检测13种呼吸道病原的检测技术。结果该方法特异性方面检测13种常见呼吸道病毒没有交叉,标本的检出率为100%;灵敏度方面达到10e2-10e1(pfu/ml)。结论该分子鉴别诊断可应用常见呼吸道病毒的检测,协助诊断病毒引起的病毒性呼吸道感染。 | 邹淑梅 韩健 温乐英 Kassi Cronin 舒跃龙 | 2006 | 中华实验和临床病毒学杂志2006，20，2： | 15 |
| 2 | Polyoma virus nephropathy in kidney transplantation显示文摘BK virus(BKV) is a polyomavirus that is able to cause renal dysfunction in transplanted grafts via BK virusassociated nephritis(BKVAN).This condition was misdiagnosed in the past due to clinical and histopthological similarities with acute rejection.Due to the prevalence of the virus in the population,it is an important pathogen in this context,and so it is important to understand how this virus functions and its' relationship with the pathogenesis of BKVN.Screening for BKV often reveals viruria and/or viremia,which then manifests as BKVN,which can be asymptomatic or result in clinical features namely renal dysfunction.The pathogenesis of BKV infection is still unclear and needs to be further investigated; nevertheless there are a variety of hypotheses that indicate that there are a host of factors that play important roles.Treatments for BKVAN include a reduction in immunosuppression,the use of antiviral therapy or the combination of both treatment options. | Jacob RW Scadden Adnan Sharif Kassi Skordilis Richard Borrows | 2017 | World Journal of Transplantation2017，7，6： | 5 |
| 3 | Radiolabeled nucleoside analogs in cancer diagnosis and therapy显示文摘 | Kassis AI Adelstein SJ Mariani G | 1996 | Q J Nucl Med1996，40，： | 2 |
| 4 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 5 | Proximal humeral fractures: how stiff should an implant be?显示文摘 | H. Lill P. Hepp J. Korner J.-P. Kassi A. P. Verheyden C. Josten G. N. Duda | 2003 | Archives of Orthopaedic and Trauma Surgery (-)2003，，2： | 2 |
| 6 | Efficient differentiation of vascular smooth muscle cells from Wharton's Jelly mesenchymal stromal cells using human platelet lysate: A potential cell source for small blood vessel engineering显示文摘BACKGROUND The development of fully functional small diameter vascular grafts requires both a properly defined vessel conduit and tissue-specific cellular populations.Mesenchymal stromal cells(MSCs) derived from the Wharton's Jelly(WJ) tissue can be used as a source for obtaining vascular smooth muscle cells(VSMCs),while the human umbilical arteries(h UAs) can serve as a scaffold for blood vessel engineering.AIM To develop VSMCs from WJ-MSCs utilizing umbilical cord blood platelet lysate.METHODS WJ-MSCs were isolated and expanded until passage(P) 4. WJ-MSCs were properly defined according to the criteria of the International Society for Cell and Gene Therapy. Then, these cells were differentiated into VSMCs with the use of platelet lysate from umbilical cord blood in combination with ascorbic acid,followed by evaluation at the gene and protein levels. Specifically, gene expression profile analysis of VSMCs for ACTA2, MYH11, TGLN, MYOCD, SOX9,NANOG homeobox, OCT4 and GAPDH, was performed. In addition,immunofluorescence against ACTA2 and MYH11 in combination with DAPI staining was also performed in VSMCs. HUAs were decellularized and served as scaffolds for possible repopulation by VSMCs. Histological and biochemical analyses were performed in repopulated h UAs.RESULTS WJ-MSCs exhibited fibroblastic morphology, successfully differentiating into'osteocytes', 'adipocytes' and 'chondrocytes', and were characterized by positive expression(> 90%) of CD90, CD73 and CD105. In addition, WJ-MSCs were successfully differentiated into VSMCs with the proposed differentiation protocol. VSMCs successfully expressed ACTA2, MYH11, MYOCD, TGLN and SOX9. Immunofluorescence results indicated the expression of ACTA2 and MYH11 in VSMCs. In order to determine the functionality of VSMCs, h UAs were isolated and decellularized. Based on histological analysis, decellularized h UAs were free of any cellular or nuclear materials, while their extracellular matrix retained intact. Then, repopulation of decellularized h UAs with VSMCs was performed for 3 wk. Decellularized h UAs were repopulated efficiently by the VSMCs. Biochemical analysis revealed the increase of total hydroyproline and s GAG contents in repopulated h UAs with VSMCs. Specifically, total hydroxyproline and s GAG content after the 1 st, 2 nd and 3 rd wk was 71 ± 10, 74 ± 9 and 86 ± 8 μg hydroxyproline/mg of dry tissue weight and 2 ± 1, 3 ± 1 and 3 ± 1μg s GAG/mg of dry tissue weight, respectively. Statistically significant differences were observed between all study groups(P<0.05).CONCLUSION VSMCs were successfully obtained from WJ-MSCs with the proposed differentiation protocol. Furthermore, h UAs were efficiently repopulated by VSMCs. Differentiated VSMCs from WJ-MSCs could provide an alternative source of cells for vascular tissue engineering. | Panagiotis Mallis Aggeliki Papapanagiotou Michalis Katsimpoulas Alkiviadis Kostakis Gerasimos Siasos Eva Kassi Catherine Stavropoulos-Giokas Efstathios Michalopoulos | 2020 | World Journal of Stem Cells2020，12，3： | 2 |
| 7 | The effects of insulin sensitizers on the cardiovascular risk factors in women with polycystic ovary syndrome显示文摘 | Kassi E Diamanti-Kandarakis E | 2008 | J Endocrinol Invest2008，31，12： | 1 |
| 8 | Metabolic syndrome: definitions and controversies 显示文摘 | Kassi E Pervanidou P Kahsas G | 2011 | BMC Med2011，9，： | 1 |
| 9 | Radiotoxicity of 75Se and 35S:theory and application to a cellular model显示文摘 | Kassis AI Adelstein SJ Haydock C | | 0，，03： | 1 |
| 10 | Correlates between hyperinsulinism and hyperandrogenemia? 显示文摘 | Kassi EN Diamanti-Kandarakis E Papavassiliou AG | 2008 | Fertil Steri12008，89，4： | 1 |
| 11 | Predictive factors for failure of percutaneous drainage of postoperative abscess after abdominal surgery显示文摘 | Fulgence Kassi Anthony Dohan Philippe Soyer Eric Vicaut Mourad Boudiaf Patrice Valleur Marc Pocard | 2013 | The American Journal of Surgery2013，，： | 1 |
| 12 | Nutritional composi- tion of novel nutraceufical egg products developed with omega-3 rich oils显示文摘 | KASSIS N BEAMER S K MATAK K E | 2010 | LWT- Food Science and Technology2010，43，8： | 1 |
| 13 | Callus response to micromovement after elongation in the rabbit 显示文摘 | Kassis B Glorion C Tabib W | 1996 | J Pediatr Orthop1996，16，4： | 1 |
| 14 | Determination of muscle loading at the hip joint for use in pre-clinical testing显示文摘 | Heller MO Bergmann G Kassi JP | | 0，，05： | 1 |
| 15 | Morbidity and Mortality of Hartmann's Procedure for Sigmoid Volvulus at the university Hospital of Cocody,Abidjan显示文摘 | Kassi AB Lebeau R Yenon KS | | 0，，03： | 1 |
| 16 | Novel ap- proach using antimicrobial catheters to improve the management of central line-associated bloodstreamin- fections in cancer patients显示文摘 | Chaftari AM Kassis C E1 Issa H | 2011 | Cancer2011，117，11： | 1 |
| 17 | Development of nutraceutical egg products with omega-3-rich oils显示文摘 | KASSIS N DRAKE S R BEAMER S K | 2010 | LWT-Food Sci- ence and Technology2010，43，5： | 1 |
| 18 | Callus response to micromovement during elongation in the rabbit 显示文摘 | Kassis B Glorion C Tabib W | 1998 | J Pediatr Orthop1998，18，5： | 1 |
| 19 | Monoclonal antibodies used in the detection and tretment of epithelial ovarian cancer 显示文摘 | Muto M G Kassis A I | 1995 | cancer1995，76，10： | 1 |
| 20 | Impact of carbapenem re- sistance on the outcome of patients' hospital-acquired bacteraemia caused by Klebsiella pneumoniae 显示文摘 | Hussein K Raz-Pasteur A Kassis I | 2013 | The Journal of Hospital Infec- tion2013，83，4： | 1 |
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