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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data显示文摘 | Andreas Hackethal Doerthe Brueggmann Michael K Bohlmann Folker E Franke Hans-Rudolf Tinneberg Karsten Münstedt | 2008 | Lancet Oncology2008，，12： | 2 |
| 5 | Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art显示文摘 | Rainer H. Müller Karsten M?der Sven Gohla | 2000 | European Journal of Pharmaceutics and Biopharmaceutics2000，，1： | 2 |
| 6 | Magmatism during extension of the lithosphere: geochemical constraints from lavas of the Shaban Deep, northern Red Sea显示文摘 | Haase Karsten M Richard Muhe Peter Stoffers | 2004 | Chemical Geology2004，166，： | 1 |
| 7 | Nasal Carriage as a Source of Staphylococcus aureus Bacteremia显示文摘 | Christof VE Karsten B Konstanze M | 2001 | N Engl J Med2001，344，： | 1 |
| 8 | Morphologic changes of extrahepaic bile duct during obstruction and subsequent decompression by endoprosthesis 显示文摘 | Karsten T M Bossnn A Kopper P J | 1992 | Surgery1992，111，8： | 1 |
| 9 | Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state or the art 显示文摘 | Muller RH Karsten M Sven G | 2000 | Eur J Pharm Biopharm2000，50，1： | 1 |
| 10 | Dental occlusion after veau-Wardiu-Kilner versus minimal incision technique repair of isolated clefts of the hard and soft palate显示文摘 | Karsten A Larson M Larson O | 2003 | Cleft Palate Craniofac J2003，40，5： | 1 |
| 11 | Inventory pooling games for expensive, low-demand spare parts显示文摘 | Karsten F Slikker M Van Houtum G J | 2012 | Naval Re- search Logistics2012，59，5： | 1 |
| 12 | Dental occlusion after Veau-Wardill-Kilner versus minimal incision technique repair of isolated clefts of the hard and soft palate 显示文摘 | Karsten A Larson M Larson O | 2003 | Cleft Palate Craniofac J2003，40，5： | 1 |
| 13 | Immunodetection of epithelial mucin (MUC1,MUC3) and mucin-associated glycotopes (TF,Tn and sialosyl-Tn) in benign and malignant lesions of colonic epithelium:apolar localization corresponds to malignant transformation显示文摘 | Cao Y Schlag P M Karsten U | 1997 | Virchows Arch1997，431，3： | 1 |
| 14 | Morphologic changes of extrahepatic bile ducts during obstruction and subsequent decompression by endoprosthesis显示文摘 | KARSTEN T M COENE P P VAN GULJK T M | 1992 | Surgery1992，111，： | 1 |
| 15 | Solid lipid nanoparticles( SLN ) for controlled drug delivery-a review of the state of the art显示文摘 | MULLER RH KARSTEN M GOHLA S | 2000 | Eur J Pharm Biopharm2000，50，1： | 1 |
| 16 | Solid lipid nanoparticles(SLN)for controlled drug delivery-a review of the state or the art显示文摘 | Müller RH Karsten M Sven G | 2000 | Eur J Pharm Biopham2000，50，6： | 1 |
| 17 | Immature,but not inactive:the tolerogenic function of immature dendritic cells显示文摘 | Karsten M Edgar S Ura B | 2002 | Immunol Cell Biol2002，80，： | 1 |
| 18 | Dental occlusion after Veau- Wardill-Kilner versus minimal incision technique repair of iso- lated clefts of the hard and soft palate显示文摘 | Karsten A Larson M Larson O | 2003 | Cleft Palate Cranio- fac2003，40，5： | 1 |
| 19 | 显示文摘 | KARSTEN H KLAUS M | 2000 | Chem Rev2000，100，： | 1 |
| 20 | Improved driving cycle for testing automotive exhaust emissions 显示文摘 | Kuhler M Karstens D | 1978 | SAE paper1978，，： | 1 |
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