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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 4 | Systemic inflammation and copd: the framing, ham heart study 显示文摘 | Walter R E Wilk J B Larson M G | 2008 | Chest2008，133，1： | 1 |
| 5 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996，275，20： | 1 |
| 6 | Effect of acute and chronic arecoline treatment on cerebralmetabolism and blood flow in the conscious rat显示文摘 | MAIESE K HOLLOWAY H H LARSON D M | 1994 | Brain Res1994，641，1： | 1 |
| 7 | Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study; evidence for susceptibility loci on 1q显示文摘 | Dupuis J Larson M G Vasan R S | 2005 | Atherosclerosis2005，182，2： | 1 |
| 8 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 9 | Locking plate technology and its applications in upper ex trem ity fracture care显示文摘 | Larson AN R izzo M | 2007 | Hand Clin2007，23，2： | 1 |
| 10 | A practical approach to guide clinicians in the evaluation of male patients with breast masses 显示文摘 | Hines S L Tan W Larson J M | 2008 | Geriatrics2008，63，6： | 1 |
| 11 | The use of a series of ketamine infusions in two patients with treatment-resistant depression显示文摘 | Messer M Haller IV Larson P | 2010 | J Neu-ropsychiatry Clin Neurosci2010，22，： | 1 |
| 12 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 13 | Chaotic pulse position modulation:a robust method of communicating with chaos显示文摘 | Sushchik M Rulkov J N Larson L | 2000 | IEEE Communications Leeters2000，4，4： | 1 |
| 14 | Absence of association of genetic linkage between the angiotensin converting-enzyme gene and left ventricular mass显示文摘 | Lindpaintner K Lee M Larson MG | 1996 | N Engl J Med1996，334，： | 1 |
| 15 | Defferential regulation of connexin 43 and connexin37 in endothelial cills by cell density,growth,and TGF -β1显示文摘 | Larson DM Wrobleski M J Sagar GDV | 1997 | Am J Physiol Cell Physiol1997，272，： | 1 |
| 16 | The failure syndrome 显示文摘 | LARSON C M R C CLUTE | 1979 | American Journal of Small Business1979，4，2： | 1 |
| 17 | Water - soluble quantum dots for muitiphoton fluorescence imaging in vivo 显示文摘 | Larson D R Zipfel W R Williams R M | 2003 | Science2003，300，5624： | 1 |
| 18 | Rapid com- munication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus显示文摘 | Vaske D A Ruohonen M K Larson R ~ | 1994 | JAnim Sci1994，72，1： | 1 |
| 19 | Minimally invasive plating of high-energy metaphyseal distal tibia fractuxe8显示文摘 | Collinge C Kuper M Larson K | 2007 | J Orthop Trauma2007，21，6： | 1 |
| 20 | Relation of brachial and digital measures of vascular function in the community : the Fram- ingham heart study 显示文摘 | Hamburg N M Palmisano J Larson M G | 2011 | Hypertension2011，57，3： | 1 |
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