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| 1 | Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity显示文摘AIM To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy(CAN). METHODS A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval(QTc) and their dispersions(dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of CAN was based upon the battery of the tests proposed by Ewing and Clarke and the consensus statements of the American Diabetes Association. CAN was diagnosed when two out of the four classical Ewing tests were abnormal. RESULTS QT, QTc and their dispersions were significantly longer(P < 0.01) in patients with cirrhosis than in controls. No significant differences in QT interval were found among the subgroups according to the etiology of cirrhosis. Multivariate regression analysis after controlling for age, gender and duration of cirrhosis demonstrated significant association between QT and presence of diabetes mellitus [standardized regression coefficient(beta) = 0.45, P = 0.02] and treatment with diuretics(beta = 0.55, P = 0.03), but not with the Child-Pugh score(P = 0.54). Prevalence of CAN was common(54.9%) among patients with cirrhosis and its severity was associated with the Child-Pugh score(r = 0.33, P = 0.02). Moreover, patients with decompensated cirrhosis had more severe CAN that those with compensated cirrhosis(P = 0.03). No significant association was found between severity of CAN and QT interval duration.CONCLUSION Patients with cirrhosis have QT prolongation. Treatment with diuretics is associated with longer QT. CAN is common in patients with cirrhosis and its severity is associated with severity of the disease. | Elias Tsiompanidis Spyros I Siakavellas Anastasios Tentolouris Ioanna Eleftheriadou Stamatia Chorepsima Anastasios Manolakis Konstantinos Oikonomou Nikolaos Tentolouris | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，1： | 6 |
| 2 | Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient显示文摘Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected. | Anastassios C Manolakis Andreas N Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 3 | Role of autophagy in gastric carcinogenesis显示文摘Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. | Apostolis Papaefthymiou Gregory Christodoulidis Apostolos Koffas Michael Doulberis Stergios A Polyzos Anastasios Manolakis Spyros Potamianos Andreas Kapsoritakis Jannis Kountouras | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 4 | Efficient Solution and Performance Analysis of 3-D Position Estimation by Trilateration 显示文摘 | Manolakis D E | 1996 | IEEE Trans on AES1996，32，4： | 1 |
| 5 | Efficient Solution and Performance A-nalysis of 3-D Position Estimation by Trilateration显示文摘 | | 1996 | IEEE Trans on AES1996，32，4： | 1 |
| 6 | Efficient solution and performance analysis of 3-D position estimation by trilateration 显示文摘 | Manolakis DE | 1996 | IEEE Transactions on Aerospace and Electronic Systems1996，32，4： | 1 |
| 7 | Effect in range difference position estimation due to stations position errors显示文摘 | MANOLAKIS D E COX M E | 1998 | IEEE1998，34，1： | 1 |
| 8 | Hyperspectral subpixel target detection using the linear mixing model 显示文摘 | Manolakis D Siracusa C Shaw G | 2001 | IEEE Transaction on Geoscience and Remote Sensing2001，39，2： | 1 |
| 9 | Wilson disease in children:analysis of 57 cases显示文摘 | Manolaki N Nikolopoulou G Daikos GL | 2009 | J Pediatr Gastroenterol Nutr2009，48，1： | 1 |
| 10 | Hyperspectral adaptive matched filter detectors:Practical performance comparison显示文摘 | Chrisitina Siracusa David Marden | 2001 | SPIE2001，4381，： | 1 |
| 11 | Dielectric and magnetic properties of new rare-earth substituted Ba-hexaferrites in the 2-18 GHz frequency range显示文摘 | Charalampos A Stergiou Ioannis Manolakis Traianos V Yioultsis | 2010 | J Magn Magn Mater2010，322，： | 1 |
| 12 | HyperspectraI image processing for au- tomatic target detection applications显示文摘 | Manolakis D | 2003 | Lincoln Lab2003，14，1： | 1 |
| 13 | Evaluation of the curing depth of two translucent composite materials using a halogen and two LED curing units显示文摘 | Polydorou O Manolakis A Hellwig E | 2008 | Clin Oral Investig2008，12，1： | 1 |
| 14 | High coercivity Gd-substituted Ba hexaferrites,prepared by chemical coprecipitation显示文摘 | Litsardakis G Manolakis I | 2007 | J Alloys Compd2007，427，12： | 1 |
| 15 | The role of small cells, coordinated multipoint, and massive MIMO in 5G显示文摘 | Jungnickel V Manolakis K Zirwas W | 2014 | IEEE Communications Magazine2014，52，5： | 1 |
| 16 | Moderate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome 显示文摘 | Manolakis AC Kapsofitakis AN Georgoulias P | 2010 | BMC Gastroenterology2010，10，： | 1 |
| 17 | Detection algorithms for hyperspectral imaging applications显示文摘 | Manolakis D Shaw G | 2002 | IEEE Signal Processing Magazine2002，19，1： | 1 |
| 18 | Detection algorithms for hyperspectral imaging applications显示文摘 | Shaw G | 2002 | IEEE Signal Processing Magazine2002，19，7： | 1 |
| 19 | The role of nerve growth factor in the prophylaxis and treatment of dia- betic foot ulcers 显示文摘 | Elisavet K Tiaka Nikolaos Papanas Anastassios C Manolakis | 2011 | Int J Bum Trauma2011，，1： | 1 |
| 20 | Increased fetuin A levels in Helicobacter pylori infection: a missing link between H. pylori and insulin resistance?显示文摘 | A. C. Manolakis E. K. Tiaka A. N. Kapsoritakis P. Georgoulias F. Tsiopoulos V. Valotassiou S. P. Potamianos | 2011 | Diabetologia2011，，2： | 1 |
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