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| 1 | Role of autophagy in liver physiology and pathophysiology显示文摘Autophagy is a highly conserved intracellular degradation pathway by which bulk cytoplasm and superfluous or damaged organelles are enveloped by double membrane structures termed autophagosomes. The autophago-somes then fuse with lysosomes for degradation of their contents, and the resulting amino acids can then recycle back to the cytosol. Autophagy is normally activated in response to nutrient deprivation and other stressors and occurs in all eukaryotes. In addition to maintaining energy and nutrient balance in the liver, it is now clear that autophagy plays a role in liver protein aggregates related diseases, hepatocyte cell death, steatohepatitis, hepatitis virus infection and hepatocellular carcinoma. In this review, I discuss the recent findings of autophagy with a focus on its role in liver pathophysiology. | Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States | 2010 | World Journal of Biological Chemistry2010，1，1： | 9 |
| 2 | Cell surface activation of progelatinase A (proMMP-2) and cell migration显示文摘Gelatinase A (MMP-2) is considered to play a critical role in cell migration and invasion. The proteinase is secreted from the cell as an inactive zymogen. In vivo it is postulated that activation of progelationase A (proMMP-2) takes place on the cell surface mediated by membrane-type matrix metalloproteinases (MT-MMPs). Recent studies have demonstrated that proMMP-2 is recruited to the cell surface by interacting with tissue inhibitor of metalloproteinases-2 (TIMP-2) bound to MT1MMP by forming a ternary complex. bee MT1-MMP closely located to the ternary complex then activates proMMP-2 on the cell surface. MT1-MMP is found in cultured invasive cancer cells at the invadopodia. The MTMMP/TIMP-2/ MMP- 2 system t bus provides localized expression of proteolysis of the extracellular matrix required for cell migration. | NAGASE HIDEAKI(Department of Biochemistry and Molecular Biology,University of Kansas Medical Center, 3901 Rainbow Blvd,Kansas City, KS 66160. E-mail: hnagase@kumc.edu) | 1998 | Cell Research1998，8，3： | 6 |
| 3 | 应用等效纬度海拔模型进行地温及多年冻土制图(英)显示文摘This research presents a method for permafrost mapping in discontinuous permafrost regions based on equivalent latitude/elevation concept in interior Alaska. In winter months, study site has a strong temperature inversion in air up to 700 m elevation. Air temperature data and the effects of slope, aspect and elevation were used to create an equivalent latitude/elevation model. This model was well correlated with mean annual surface temperature (0\^79). In this watershed, the thawing index (\%I\%\-t≈\{1 400\} ℃\5days) at the ground surface and snow depth do not vary greatly from south facing to north facing slopes. The primary controlled factor that determines the mean annual surface temperature was the winter surface temperature. The permafrost stability is effectively controlled by the freezing index. We determined 37\^5% of Caribou-Poker Creeks Research Watershed has unstable or thawing permafrost. At least 2\^1% of the permafrost in this watershed may have disappeared in the last 90 years due to climate warming. This method makes it possible to evaluate the permafrost stability in the present, past and future. | Kenji Yoshikawa\+1,\ Larry D. Hinzman\+1,\ Prasad Gogineni\+2 (1.Water and Environmental Research Center, University of Alaska Fairbanks, USA 2.The University of Kansas, Radar Systems and Remote Sensing Laboratory, USA) | 2002 | 冰川冻土2002，24，5： | 5 |
| 4 | The Australasian frog family Ceratobatrachidae in China,Myanmar and Thailand:discovery of a new Himalayan forest frog clade显示文摘In an effort to study the systematic affinities and specieslevel phylogenetic relationships of the enigmatic anurans variably assigned to the genera Ingerana or Limnonectes(family Dicroglossidae),we col ected new molecular sequence data for five species including four Himalayan taxa,Limnonectes xizangensis,Lim.medogensis,Lim.alpina,Ingerana borealis and one southeast Asian species,I.tasanae,and analyzed these together with data from previous studies involving other ostensibly related taxa.Our surprising results demonstrate unequivocal y that Lim.xizangensis,Lim.medogensis and Lim.alpina form a strongly supported clade,the sister-group of the family Australasian forest frog family Ceratobatrachidae.This discovery requires an expansion of the definition of Ceratobatrachidae and represents the first record of this family in China.These three species are distinguished from the species of Ingerana and Limnonectes by the:(1)absence of interdigital webbing of the foot,(2)absence of termina discs on fingers and toes,(3)absence of circumargina grooves on the fingers and toes,and(4)absence of tarsal folds.Given their phylogenetic and morphologica distinctiveness,we assign them to the oldest available generic name for this clade,Liurana Dubois 1987,and transfer Liurana from Dicroglossidae to the family Ceratobatrachidae.In contrast,Ingerana tasanae was found to be clustered with strong support with the recently described genus Alcalus(Ceratobatrachidae),asmall clade of otherwise Sundaic species;this constitutes a new record of the family Ceratobatrachidae for Myanmar and Thailand.Final y,Ingerana borealis clustered with the 'true' Ingerana(family Dicroglossidae),for which the type species is I.tenasserimensis. | Fang YAN Ke JIANG Kai WANG Jie-Qiong JIN Chatmongkon SUWANNAPOOM Cheng LI Jens V.VINDUM Rafe M.BROWN Jing CHE State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences Southeast Asia Biodiversity Research Institute,Chinese Academy of Sciences Sam Noble Oklahoma Museum of Natural History and Department of Biology,University of Oklahoma School of Agriculture and Natural Resources,University of Phayao Imaging Biodiversity Expedition Department of Herpetology,California Academy of Sciences Biodiversity Institute and Department of Ecology and Evolutionary Biology,1345 Jayhawk Blvd,University of Kansas | 2016 | Zoological Research2016，37，1： | 4 |
| 5 | Small incision cataract extraction and implantation surgery using a manual phacofragmentation technique显示文摘 | Kansas PG Sax R | 1988 | Cataract Refract Surg1988，14，3： | 1 |
| 6 | Selectins and their ligands:current concepts and controversies显示文摘 | | 1996 | Blood1996，88，： | 1 |
| 7 | Controlla- bly mobile infrastructure for low energy embedded net- works 显示文摘 | Somasundara A A Kansa A Jea D D | 2006 | IEEE Trans on Mobile Computing2006，5，8： | 1 |
| 8 | Multiquadrics--a scattered data approximation scheme with applications to computational fluid-dynamics-q surface approximations and partial derivative estimates显示文摘 | Kansa E J | 1990 | Computers and Mathematics with Applications1990，19，89： | 1 |
| 9 | Applications of the mutiquadric method for the solution of elliptic partial differen- tial equations显示文摘 | Saran M Kansa E J Gupta S | 1997 | Applied Mathematics and Computation1997，84，23： | 1 |
| 10 | Multiquadrics-A Scattered Data Approxi-mation Scheme with Applications to Computational Fluid-Dynamics-I Surface Approximations and Partial Deri-vative Estimates显示文摘 | KANSA E J | 1990 | Computers & Mathematics with Applications1990，19，8： | 1 |
| 11 | Preconditioning for Radial Basis Functions with Domain Decomposition Methods显示文摘 | LING L KANSA E J | 2004 | Mathematical and Computer Modeling2004，40，13： | 1 |
| 12 | Circumventing the ill-conditioningproblem with multiquadratic radial basis functions:applications to elliptic partial differential equations显示文摘 | KANSA E J HON Y C | 2000 | Comput Math Appl2000，39，78： | 1 |
| 13 | Multi-quadrics-a scattered data approximation scheme with applications to computational fluid dynamics-Ⅱ显示文摘 | E J Kansa | 1998 | Computers in Mathematical Applications1998，，9： | 1 |
| 14 | Selectins and their ligands:current concepts and controversies 显示文摘 | KANSAS G S | 1996 | Blood1996，88，9： | 1 |
| 15 | Selectins and their ligands : current concepts and controversies显示文摘 | Kansas G S | 1996 | Blood1996，88，9： | 1 |
| 16 | Improved Accuracy of Multiquadric Interpolation Using Variable Shape Parameters显示文摘 | Kansa E J Carlson R E | 1992 | Comp Math with Applications1992，24，12： | 1 |
| 17 | Selections and their ligands: current concepts and controversies显示文摘 | Geoffrey S Kansas | 1996 | Blood1996，88，： | 1 |
| 18 | Multiquadrics: a scattered data approxima- tion scheme with applications to computational fluid dy- namics i: surface approximations and partial derivative estimates 显示文摘 | Kansa E J | 1990 | Comput Math Appl1990，19，89： | 1 |
| 19 | Circumventing theⅢ-conditioning problem with multi quadric radial basis functions:applications to elliptic partial differential equations显示文摘 | KANSA E J HON Y C | 2000 | Computers and Mathematics with Applications2000，39，78： | 1 |
| 20 | Multiquadrics-a scattered data approximation scheme with application to computation fluid dynamics显示文摘 | Kansa E J | 1990 | Comput Math Appl1990，19，89： | 1 |
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