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| 1 | Molecular mechanism about lymphogenous metastasis of hepatocarcinoma cells in mice显示文摘AIM To investigate the correlation between lymphogenous metastasis and matrix metalloproteinases (MMPs) activity and the expression of Fas Iigand of tumor cells in lymph nodes.METHODES Fifty-six inbred 615-mice were equally divided into 2 groups and inoculated with Hca-F and Hca-P cells. Their lymph node metastatic rates were examined.Growth fraction of lymphocytes in host lymph nodes was detected by flow cytometry. The Hca-F and Hca-P cells were cultured with extract of lymph node, liver or spleen.The quantity of MMPs in these supernatants was examined by zymographic analysis. The expression of Fas ligand,PCNA, Bcl-2 protein of Hca-F and Hca-P cells in the mice were examined by immunohistochemistry. The apoptosis signals of macrophages in lymph nodes were observed with in situ DNA fragmentation.RESULTS On the 28th day post-inoculation, the lymph node metastatic rate of Hca-F was 80% (16/20), whereas that of Hca-P was 25% (5/20). The growth fraction of lymphocytes was as follows: in the Hca-F cells, the proliferating peak of lymphocytes appeared on the 14th day post-inoculation and then decreased rapidly, while in HcaP cells, the peak appeared on the 7th day post-inoculation and then kept at a high level. With the extract of lymph node, the quantity of the MMP-9 activity increased (P<0.01) and active MMP-9 and MMP-2 were produced by both Hca-F and Hca-P tumor cells, which did not produce MMPs without the extract of lymph node or with the extracts of the liver and spleen. The expression of Fas Ligand of Hca-F cells was stronger than that of Hca-P cells (P<0.01). The expressions of PCNA and Bcl-2 protein of Hca-F cells in the tumors of inoculated area were the same as that of Hca-P cells. In situ DNA fragmentation showed that the positive signals of macrophages were around HcaF cells.CONCLUSION Secretion of MMPs which was associated with metastatic ability of Hca-F and Hca-P tumor cells depends on the environment of lymph nodes. The increased expression of Fas ligand protein of Hca-F tumor cells with high lymphogenous metastatic potential in lymph nodes may help tumor cells escape from being killed by host lymphocytes. | Li Hou Ying Li Yong-Hua Jia Bo Wang Yi Xin Mao-Ying Ling Shen Lü Department of Pathology,Dalian Medical University,Dalian 116027,Liaoning Province,ChinaDepartment of Biochemistry,Dalian Medical University,Dalian 116027,Liaoning Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 47 |
| 2 | An Sm-Nd isotopic dating study of the Archean Kongling Complex in the Huangling area of the Yangtze Craton显示文摘Sm Nd isotopic compositions of associated amphibolites, TTG gneisses and granitic gneisses from the Archean Kongling Complex of the Yangtze Craton, South China are systematically analyzed. The results show that the amphibolites and TTG gneisses have a similar age of ca. 2 700 Ma, which well agrees with zircon U Pb dating of previous studies. However, their ε Nd ( t ) are different, suggestive of possible dissimilarity in source composition. | Ling, WL Gao, S Zheng, HF Zhou, L Zhao, ZB | 1998 | Chinese Science Bulletin1998，43，14： | 13 |
| 3 | Curative effect of acupuncture on quality of life in patient with depression: a clinical randomized single-blind placebo-controlled study显示文摘OBJECTIVE:To evaluate the effect of acupuncture on the quality of life in patients with depression by clinical randomized single-blind placebo-controlled study.METHODS:one hundred and sixty-three cases of depression according with the inclusion criteria were randomly divided into a group of acupuncture dredging liver and regulating flow of theosophy(group 1),a group of acupoint shallow stab(group 2)and a group of non-acupoint shallow stab(group 3)at 1∶1∶1 ratio,and treated with acu-puncture,moxibustion,and intradermal embedding of needle,twice a week,for a total of 12 weeks.Scale of Quality of Life(SF-36)was used to measure the scores at four different time points and evaluate the effect of acupuncture on the quality of life of the patients with depression.RESULTS:At each time point after treatment,in scores of the 8 items,physical function,physical role,bodily pain,general physical condition,energy,social function,emotional function and mental health there were statistically significant differences among the 3 groups(P<0.0125).CONCLUSION:Acupuncture can effectively improve the quality of life of patients with depression. | Fan Ling Fu Wenbin Chen Zhao Xu Nenggui Liu Jianhua LǚAiping Li Ziping Su Shengyong Wu Taixiang Ou Aihua | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 12 |
| 4 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 5 | Differences of promethazine and terfenadine on ion channels in guinea pig ventricular myocytes显示文摘 | LI Xue-wen NIU Shuan-cheng ZHANG Xuan-ping Lü Ji-yuan BAI Feng ZHANG Ling WU Bo-wei | 2006 | Chinese Medical Journal2006，，11： | 6 |
| 6 | Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions显示文摘 | Jian Gu Xuhao Ni Xiongxiong Pan Hao Lu Yunjie Lu Jie Zhao Song Guo Zheng Keli L Hippen Xuehao Wang Ling Lu | 2017 | Cellular & Molecular Immunology2017，14，6： | 6 |
| 7 | Parameter identification and synchronization of spatiotemporal chaos in an uncertain Gray-Scott system显示文摘The zero-asymptotic property of sliding variables in discrete systems is extended to a continuous one and applied to partial differential equations which describe spatiotemporal chaos. A method of chaos synchronization and parameter identifi-cation is proposed. The synchronization controllers and the parameter recognizers are designed. The uncertain Gray-Scott system is taken as an example to verify the effectiveness of the method. Simulation results show that the identification vari-ables in the parameter recognizers may take the place of the unknown parameters in both target and response systems. Global synchronization of the two spatio-temporal chaotic systems with uncertain parameters may be realized quickly after controllers are added. | LüLing LI Yi GUO ZhiAn | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 5 |
| 8 | Spatial and Seasonal Variations of Nutrients in Sediment Profiles and Their Sediment-Water Fluxes in the Pearl River Estuary,Southern China显示文摘Three cruises were launched in the Pearl River Estuary(PRE)in 2005 to investigate the biogeochemical cycling of nutrients associated with early diagenesis related to degradation of organic matter.Seasonal and spatial variations of pore water nutrient concentrations and profile patterns in sediments were studied.Nutrient fluxes at the sediment-water interface(SWI)were measured by incubation experiments,and we here discussed the accumulation and transformation processes of nutrients at the SWI.The nutrients generally decreased from the Pearl River outlets downstream,indicating anthropogenic influences on the nutrient inputs in the estuary.NO3-N concentration was the highest of the three forms of DIN(dissolved inorganic nitrogen,the sum of NH4-N,NO3-N and NO2-N)in the overlying water,and NH4-N was the main component of DIN in pore water.The gradual increase of NH4-N and the rapid decrease of NO3-N with sediment depth provided the evidence for anaerobic conditions below the SWI.Negative fluxes of NO3-N and positive fluxes of NH4-N were commonly observed,suggesting the denitrification of NO3-N at the SWI.The DIN flux direction suggested that the sediment was the sink of DIN in spring,however,the sediment was generally the source of DIN in summer and winter.PO4-P distribution patterns were distinct while SiO4-Si inconspicuously varied in sediment profiles in different seasons.The flux results indicated that PO4-P mainly diffused from the water column to the sediment while SiO4-Si mainly diffused from the sediment to the water column.Generally,the incubated fluxes were the coupling of diffusion,bioturbation and biochemical reactions,and were relatively accurate in this study. | Ling Zhang Lu Wang Kedong Yin Ying Lü Yongqiang Yang Xiaoping Huang | 2014 | Journal of Earth Science2014，25，1： | 5 |
| 9 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 10 | Isolation and Expression Analysis of Two Genes Encoding Cinnamate 4-Hydroxylase from Cotton(Gossypium hirsutum)显示文摘Two genes(GhC4H1 and GhC4H2) that encode putative cotton cinnamate 4-hydroxylases that catalyze the second step in the phenylpropanoid pathway were isolated from developing cotton fibers. GhC4H1 and GhC4H2 each contain open reading frames of 1 518 base pairs(bp) in length and both encode proteins consisting of 505 amino acid residues. They are 90.89% identical to each other at the amino acid sequence level and belong to class I of plant C4 Hs. GhC4H1 and GhC4H2 genomic DNA are 2 247 and 2 161 bp long, respectively, and contain two introns located at conserved positions relative to the coding sequence. GhC4H1 and GhC4H2 promoters were isolated and found to contain many cis-elements(boxes P, L and AC-I element) previously identified in the promoters of other phenylpropanoid pathway genes. Histochemical staining showed GUS expression driven by the GhC4H1 and GhC4H2 promoters in ovules and fibers tissues. GhC4H1 and GhC4H2 were also widely expressed in other cotton tissues. GhC4H2 expression reached its highest level during the elongation stage of fiber development, whereas GhC4H1 expression increased during the secondary wall development period in cotton fibers. Our results contribute to a better understanding of the biochemical role of GhC4H1 and GhC4H2 in cotton fiber development. | NI Zhi-yong LI Bo Neumann M Peter Lü Meng FAN Ling | 2014 | Journal of Integrative Agriculture2014，13，10： | 3 |
| 11 | Blast furnace ironmaking process with super high TiO_(2) in the slag:Density and surface tension of the slag显示文摘Aiming at the process of smelting ultra-high(>80%)or even full vanadium titanomagnetite in blast furnace,we are conducting a series of works on physics character of high TiO_(2) bearing blast furnace slag(BFS)for slag optimization.This work discussed the density and surface tension of high TiO_(2) bearing BFS using the Archimedean principle and the maximum bubble pressure method,respectively.The influence of TiO_(2) content and the MgO/CaO mass ratio on the density and surface tension of CaO-SiO_(2)-TiO_(2)-MgO-Al_(2)O_(3)slags were investigated Results indicated that the density of slags decreased with the TiO_(2) content increasing from 20wt%to 30wt%,but it increased slightly with the MgO/CaO mass ratio increasing from 0.32 to 0.73.In view of silicate network structure,the density and the degree of polymerization(DOP)of network structure have a consistent trend.The addition of TiO_(2) reduced(Q^(3))^(2)/(Q^(2)) ratio(Q^(2) and Q^(3) represent structural unit with bridge oxygen number of 2 and 3,respectively)and then decreased DOP,which led to the decrease of slag density.The surface tension of CaO-SiO_(2)-TiO_(2)-MgO-Al_(2)O_(3) slags decreased dramatically with the TiO_(2) content increasing from 20wt%to 30wt%.Conversely,it increased with the MgO/CaO mass ratio increasing from 0.32 to 0.73.Furthermore,the iso-surface tension lines were obtained under 1723 K using the Tanaka developed model in view of Butler formula.It may be useful for slag optimization of ultra-high proportion(>80%)or even full vanadium titanomagnetite under BF smelting. | Zhengde Pang Yuyang Jiang Jiawei Ling Xuewei Lü Zhiming Yan | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 3 |
| 12 | Shenfuqiangxin Capsule inhibits apoptosis through mitogen-activated protein kinase signal pathway in rats with cardio-renal syndrome induced by infrarenal aortic-clamping显示文摘OBJECTIVE: To investigate the effect of Shenfuqiangxin capsule and the underlying mechanism on cardio-renal syndrome(CRS) in rats induced by infrarenal aortic-clamping after renal ischaemia.METHODS: Male Wistar rats underwent infrarenal aortic-clamping after renal ischaemia or sham operation. The surviving CRS rats were divided randomly into three groups: CRS group(CRS + 10 m L·kg-1·d-1pure water by gavage), SFQX group(CRS + 13.2 g crude drug·kg- 1·d- 1Shenfuqiangxin by gavage),and handleregionpeptide(HRP)group(CRS+10mg/kg HRP by vein). Sham operation rats were given10 m L·kg-1·d-1pure water. Treatments were given8 weeks after surgery, which lasted for 4 weeks. Therats were detected for heart structure and function by transthoracic echocardiography. PPR m RNA was detected by Reverse Transcription Polymerase Chain Reaction(RT-PCR). To determine whether the mitogen-activated protein kinase(MAPK) signal pathway is included in the heart and kidney protective function of Shenfuqiangxin capsule, MAPK related proteins such as posophorylated C-Jun amino terminal kinase(p-JNK), posophorylated extracellular signal-regulated kinase ?(p-ERK1/2), posophorylated p38(p-p38) were examined by Western Blot.Apoptosis in heart and kidney tissues were detected by d UTP Nick End Labeling staining.RESULTS: Shenfuqiangxin capsule alleviated myocardial apoptosis and inhibited PRR m RNA expression and p-JNK, p-ERK1/2, p-p38 proteins expression in CRS rats.CONCLUSION: All the results suggest that Shenfuqiangxin capsule improves the injured heart and kidney function maybe through inhibition of MAPK response pathway. | Wang Lei Wang Zi Yuan Ling Hao Di LüNan Li Xu | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 3 |
| 13 | Crustal thickness and composition in the South China Block:Constraints from earthquake receiver function显示文摘Crustal thickness and composition are closely related to geology and tectonic evolution of the region.Studying the differences in the crustal thickness and composition of the South China Block(SCB)is important to gain a comprehensive understanding of multi-phase amalgamation,breakup,reworking,and regional geodynamic processes.In this study,teleseismic data from 135 high-density portable broadband stations from Sino Probe were processed using Common Conversion Point(CCP)stacking and H-κstacking methods.The Moho depth and P-wave and S-wave velocity ratio(V_(p)/V_(s))were studied.Our results revealed several insights about the tectonic processes in the SCB.First,the crustal structure and V_(p)/V_(s)ratios of the Cathaysia Block,Jiangnan Orogenic Belt,and Yangtze Block were significantly different.The average depth of the Moho in the Cathaysia Block was approximately 31 km,and the V_(p)/V_(s)ratios increased from the inland area(1.66)to the coastal area(1.78),indicating the oceanward increase of mafic proportion in the lower crust,which is related to the influence of the Paleo-Pacific Plate westward subduction.Second,the crustal thickness of Jiangnan Orogenic Belt deepens from east ca.31 to the west ca.42 km and the V_(p)/V_(s)ratios varied from 1.75 to 1.64,illustrating a relatively felsic crust,which could have been related to the Mesozoic upper crustal thickening under compression followed by the lower crust removal under the extensional background.Third,the average crustal thickness of the Yangtze Block was 42 km,and the V_(p)/V_(s)ratios ranged from 1.64 to 1.84,presenting a positive correlation between the Moho depth and the V_(p)/V_(s)ratio,which is explained by the relatively thick mafic lower crust.Based on the variations in the crustal structure and V_(p)/V_(s)ratios of the profile,we inferred that the central part of the Jiangnan Orogenic Belt was bounded by the Jiangshan-Shaoxing-Hengyang in the east and the Jiujiang-Shitai-Jishou in the west.The small-scale Moho depth undulations at the intersection of the Cathaysia Block and the Jiangnan Orogenic Belt could be related to the Mesozoic compression-extension geodynamic transformation. | Changxin CHEN Qingtian LÜ Ling CHEN Danian SHI Jiayong YAN Yinshuang AI | 2022 | Science China Earth Sciences2022，65，4： | 3 |
| 14 | ANALYSIS OF STRESS CONCENTRATIONS IN UNIDIRECTIONAL COMPOSITES TAKING INTO ACCOUNT THE TENSILE LOAD IN THE MATRIX显示文摘A modified shear-lag model accounting for the effect of the tensile stiffness of the ma-trix is proposed for solving the stress redistribution due to the failure of fibers and matrix in unidirec-tionally fibre-reinforced composites.The advantages of this model are simple,reasonable and accurateby comparison with the other similar modified shear-lag models.It can be further extended to study thestress redistribution with interracial damage between fibres and matrix.This paper quantitatively dis-cusses the influence of the tensile stiffness ratio of matrix to fibre and.of the fibre volume fraction onthe stress concentration in the fibres and matrix adjacent to cut fibres and matrix,and suggests that theinfluence of the matrix stiffness on the stress concentration can be neglected when the matrix stiffnessis low,such as polymer matrix composites,and the fibre volume fraction is high.For other cases suchas ceramic and metal matrix composites,the tensile load of the matrix cannot be neglected in the shear-lag analysis. | Ling, L Zeng, QD | 1998 | Acta Mechanica Solida Sinica1998，11，4： | 3 |
| 15 | Effect of Honghua (Flos Carthami) on nitric oxide production in RAW 264.7 cells and α-glucosidase activity显示文摘OBJECTIVE: To study the effects of extracts from Honghua(Flos Carthami) on lipopolysaccharide induced nitric oxide(NO) production in RAW 264.7cells and the influence of the extracts on yeastα-glucosidase activity. The total flavonoid content of the extracts was also determined.METHODS: Cytotoxicity of the extracts to RAW264.7 cells was evaluated by the ATPlite? method.Inhibitory effects of the extracts on NO production were evaluated by Griess assay. Curcumin was used as a positive control. Screening of extracts for potential α-glucosidase inhibitors was done by a fluorometric assay.The assay was based on the hydrolysis of 4-methylumbelliferyl-a-D-glucopyranoside to form the fluorescent product, 4-methylumbelliferone. Acarbose was used as a positive control. The total flavonoid content was tested using kaempferol as the standard.RESULTS: There were significant inhibitory effects on NO production when the extracts were 25-100μg/mL(P<0.05) and curcumin was 2-4 μg/mL(P<0.001). The extracts showed an inhibitory effect onα-glucosidase activity at the concentrations of15.6-125 μg/mL with a half maximal(50%) inhibitory concentration(IC50) of(32.8±5.7) μg/mL, compared with the IC 50 of acarbose at(1.8±0.4) μg/mL.There was a significant difference between the two IC50values(P<0.001). The total content of flavonoids per gram of dried herb was1.14 mg.CONCLUSION:Honghua(Flos Carthami)showed in hibitory effects on NO production in activated RAW264.7 macrophage cells and an inhibitory effect on yeast α-glucosidase. There might be a relationship between these pharmacological effects and its flavonoid content. | Hui Liao Linda Banbury Hongping Liang Xiaomin Wang Xiaokai Lü Ling Hu Jin Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 2 |
| 16 | On the universal third order Stokes wave solution显示文摘This paper presents a universal third-order Stokes solution with uniform current. This solution is derived on the basis of potential theory by expanding the free surface and potential function in Fourier series and determining the Fourier coefficients by solving a set of nonlinear algebraic equations through the Taylor expansion and perturbation method. The universal solution is expressed upon the still water depth with the still water level as datum and retains a global perturbation parameter. The wave set-up term generated by the self-interaction of oscillatory waves is explicitly included in the free surface function. With the use of different definitions for the wave celerity, different water levels as the datum, different non-dimensional variables as the perturbation parameter, and different treatments for the total head, the universal solution can be reduced to the existing various Stokes solutions, thus explaining the reasons and the physical significance of different non-periodic terms in them, such as the positive or negative constant term in the free surface expression and the time-or space-proportional term in the potential function. | SONG ZhiYao ZHAO HongJun LI Ling Lü GuoNian | 2013 | Science China Earth Sciences2013，56，1： | 2 |
| 17 | Determination of Cordycepin in Cordyceps kyushuensis by Capillary Electrophoresis and its Antitumour Activity显示文摘A simple, rapid and low-cost method of determination for cordycepin in Cordyceps kyushuensis by capillary zone electrophoresis (CZE) was developed. Based on the finding that there is a high concentration of cordycepin in both natural and cultured Cordyceps kyushuensis, the in vitro antitumor activity of cordycepin and the water extracts of Cordyceps kyushuensis has been investigated. This is the first report about the antitumor effect of Cordyceps kyushuensis. | Ying Jie SUN, Jian Ya LING, Peng L Han Xing ZHANG, Chang Kai ZHANG* State Key Laboratory of Microbial Technology, Life Science School of Shandong University, Jinan 250100 | 2003 | Chinese Chemical Letters2003，14，7： | 2 |
| 18 | Changes in uhrastructure and abscisic acid level and response to applied gibberellins in Taxus rnalrei seeds treated with warm and cold stratification显示文摘 | CHING T C LING L H TSAN P L | 1998 | Annals of Botany1998，81，： | 1 |
| 19 | Preparation of mesocarbon microbeads from coal tar 显示文摘 | LU Y G LING L C WU D | 1999 | Journal of Material Science1999，34，16： | 1 |
| 20 | Genomic-Sequence Comparison of Two Unrelated Isolates of the Human Gastric Pathogen Helicobacterpylori 显示文摘 | Alm R A Ling L L Moir D T | 1999 | Nature1999，397，14： | 1 |
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