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| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | 1100kV/1200kV断路器大功率试验(英文)显示文摘特高压(UHV)断路器试验本身就是一项挑战,当前,KEMA已开发了用于超高压和特高压开关设备大功率测试装置。鉴于特高压断路器一般至少由双断口灭弧室组成,需要做验证其正常电流(或故障电流)开断能力的局部试验,可以只针对断路器单断口(即断路器的1/2或1/4)来进行。例如,装有均压电容的瓷柱式断路器的情形就是这样。然而,为满足对金属封闭式开关设备的试验要求(见IEC61633),在带电部件和外壳之间以及在分闸过程应具备正确的电介质应力,不做断路器整极试验在技术上是不正确的。这就要求开发新的UHV断路器试验电路。关键之处在于使用一种双级合成电路,其中一级电路放置在测试对象的附近。这种做法的好处是,测试对象的外壳可以保持地电位。各种800kV以及1100或1200kV断路器整极全面试验均证明这种方法是有效可行的。文章中展示了试验的例子。 | René Peter Paul Smeets Sander Kuivenhoven Piet Knol Adriaan Hofstee | 2009 | 南方电网技术2009，3，6： | 4 |
| 3 | Review: Improving our knowledge of male mosquito biology in relation to genetic control programmes显示文摘 | Rosemary Susan Lees Bart Knols Romeo Bellini Mark Q. Benedict Ambicadutt Bheecarry Hervé Christophe Bossin Dave D. Chadee Jacques Charlwood Roch K. Dabiré Luc Djogbenou Alexander Egyir-Yawson René Gato Louis Clément Gouagna Mo’awia Mukhtar Hassan Shakil A | 2013 | Acta Tropica2013，，： | 2 |
| 4 | Landscape ecological assessment: A tool for integrating biodiversity issues in strategic environmental assessment and planning显示文摘 | Mortberg U M Balfors B Knol W C | 2007 | Journal of Environmental Management2007，82，： | 1 |
| 5 | Diagnostic tests based on human basophils : potentials, pitfalls and perspectives 显示文摘 | Kleine-Tebbe J Erdmann S Knol E F | 2006 | Int Arch Allergy Immunol2006，141，1： | 1 |
| 6 | Effect of multilev- el Botulinum toxin A and comprehensive rehabilitation on gait in cerebral palsy 显示文摘 | Scholtes VA Dallmeijer AJ Knol DL | 2007 | Pediatr Neurol2007，36，： | 1 |
| 7 | Different strains of Propionibacterium aches modulate differently the cutaneous innate immunity显示文摘 | Jasson F Nagy I Knol AC | 2013 | Exp Der- matol2013，22，9： | 1 |
| 8 | The suitability of dogs as guide dogs for the blind: Criteria and testing procedures 显示文摘 | Knol BW Roozendaal C Vandenbogaard L | 1988 | Vet Q1988，10，3： | 1 |
| 9 | About the cutaneous tar- gets of bexarotene in CTCL patients 显示文摘 | Knol AC Qu6reux G Brocard A | 2010 | Exp Dermatol2010，19，8： | 1 |
| 10 | Analysis of arthropod blood meals using molecular genetic markers显示文摘 | Mukabana WR Takken W Knols BGJ | | 0，，11： | 1 |
| 11 | Hidradenitis suppurativa and Zinc: a new therapeutic approach显示文摘 | Broeard A Knol AC Khammari A | 2007 | Dermatology2007，214，2： | 1 |
| 12 | Effects of galactooligosaccharide and long-chain fruc- tooligosaccharide supplementation during pregnancy on maternal and neonatal mierobiota and immunity-a randomized, double-blind, placebo-controlled study 显示文摘 | SHADID R HAARMAN M KNOL J | 2007 | Am J Clin Nutr2007，86，： | 1 |
| 13 | Directed genomic integration,gene replacement,and integrative gene expression in Streptococcus thermophilus显示文摘 | Mollet B Knol J Poolman B | 1993 | J Bacteriol1993，175，： | 1 |
| 14 | Efficacy of preoperative biliary tract decompression in patients with obstructive janndice显示文摘 | Gundry SR Strodel WE Knol JA | 1984 | Arch Surg1984，119，6： | 1 |
| 15 | Landscape eco- logical assessment: a tool for integrating biodiversity issues in strategic environmental assessment and plan- ning 显示文摘 | Mortberg U M Ballots B Knol W C | 2007 | Journal of Environmental Management2007，8，2： | 1 |
| 16 | Innovative Behaviour: the effect of stuctural and psychologcal empowerment nurses显示文摘 | Knol J Van Linge R | 2009 | J Adv Nuts2009，65，2： | 1 |
| 17 | Comparisons of dynamic infusion and delayed computed tomography, intraoperative ultrasound, and palpation in the diagnosis of liver metastases显示文摘 | Knol J A Marn C S Francis I R | 1993 | Am JSurg1993，165，1： | 1 |
| 18 | Analysis of stillbirth in different lines of pig显示文摘 | Leenhouwers J I van der Lende T Knol E F | 1999 | Livest Prod Sci1999，57，： | 1 |
| 19 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 20 | Requirements for effective IgE cross-linking on mast cells and basophils 显示文摘 | Knol EF | 2006 | Mol Nutr Food Res2006，50，7： | 1 |
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