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| 1 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 4 |
| 2 | Nrf2 is required for normal postnatal bone acquisition in mice显示文摘A large body of literature suggests that bone metabolism is susceptible to the ill effects of reactive species that accumulate in the body and cause cellular dysfunction. One of the body's front lines in defense against such damage is the transcription factor, Nrf2. This transcription factor regulates a plethora of antioxidant and cellular defense pathways to protect cells from such damage. Despite the breadth of knowledge of both the function of Nrf2 and the effects of reactive species in bone metabolism, the direct role of Nrf2 in skeletal biology has yet to be thoroughly examined. Thus, in the current study, we have examined the role of Nrf2 in postnatal bone metabolism in mice. Mice lacking Nrf2(Nrf22/2) exhibited a marked deficit in postnatal bone acquisition,which was most severe at 3 weeks of age when osteoblast numbers were 12-fold less than observed in control animals. While primary osteoblasts from Nrf22/2mice functioned normally in vitro, the colony forming capacity of bone marrow stromal cells(BMSCs) from these mice was significantly reduced compared to controls.This defect could be rescued through treatment with the radical scavenger N-acetyl cysteine(NAC), suggesting that increased reactive species stress might impair early osteoblastogenesis in BMSCs and lead to the failure of bone acquisition observed in Nrf22/2animals. Taken together, these studies suggest Nrf2 represents a key pathway in regulating bone metabolism, which may provide future therapeutic targets to treat osteoporosis. | Jung-Hyun Kim Vandana Singhal Shyam Biswal Rajesh K Thimmulappa Douglas J Di Girolamo | 2014 | Bone Research2014，2，4： | 3 |
| 3 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7显示文摘The voltage-gated Na^+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monoclonal antibody(SVmab) reduces Na+ currents and pain and itch responses in mice. Here, we investigated whether recombinant SVmab(rSVmab) binds to and blocks Nav1.7 similar to SVmab. ELISA tests revealed that SVmab was capable of binding to Nav1.7-expressing HEK293 cells,mouse DRG neurons, human nerve tissue, and the voltagesensor domain Ⅱ of Nav1.7. In contrast, rSVmab showed no or weak binding to Nav1.7 in these tests. Patch-clamp recordings showed that SVmab, but not rSVmab, markedly inhibited Na+ currents in Nav1.7-expressing HEK293 cells. Notably, electrical field stimulation increased the blocking activity of SVmab and rSVmab in Nav1.7-expressing HEK293 cells. SVmab was more effective than rSVmab in inhibiting paclitaxel-induced mechanical allodynia. SVmab also bound to human DRG neurons and inhibited their Na^+ currents. Finally, potential reasons for the differential efficacy of SVmab and rSVmab and future directions are discussed. | Sangsu Bang Jiho Yoo Xingrui Gong Di Liu Qingjian Han Xin Luo Wonseok Chang Gang Chen Sang-Taek Im Yong Ho Kim Judith A.Strong Ma-Zhong Zhang Jun-Ming Zhang Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 2 |
| 4 | Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma显示文摘 | Anna S. Lok Richard K. Sterling James E. Everhart Elizabeth C. Wright John C. Hoefs Adrian M. Di Bisceglie Timothy R. Morgan Hae–Young Kim William M. Lee Herbert L. Bonkovsky Jules L. Dienstag | 2010 | Gastroenterology2010，，2： | 2 |
| 5 | High - resolution CT of the pterygopalation fossa and its communications显示文摘 | Kim HS Kim DI Chung IH | 1996 | Neuroradiology1996，38，1： | 1 |
| 6 | Reconstructive endovascu- lar treatment of fusiform or ultrawide-neck circumferential aneurysms with multiple overlapping Enterprise stents and coiling 显示文摘 | Jeon P Kim BM Kim DI | 2012 | Am J Neuroradiol2012，33，： | 1 |
| 7 | Pulmonary sequestration with right coronary artery supply显示文摘 | Lee DI Shim JK Kim JH | 2008 | Yousei Med J2008，49，： | 1 |
| 8 | Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine显示文摘 | DI R KIM J MARTIN M N | 2003 | Journal of Agricultural and Food Chemistry2003，51，19： | 1 |
| 9 | Results of transvenous embolization of cavernousdural arteriovenous fistula: a single-center experience with emphasis on complications and management 显示文摘 | Kim DJ Kim DI Suh SH | 2006 | AJNR2006，27，10： | 1 |
| 10 | Effect of 3 - aminobenzamide, PARP inhibitor, on matrix metalloproteinase -9 level in plasma and brain of ischemic stroke model 显示文摘 | Koh SH Chang DI Kim HT | 2005 | Toxicology2005，214，12： | 1 |
| 11 | Idiopathic hypertrophic pachymeningeal lesions:correlation between clinical patterns and neuroimaging characteristics显示文摘 | Bang OY Kim DI Yoon SR | 1998 | Eur Neurol1998，39，1： | 1 |
| 12 | Postoperative evaluation of moyamoya disease with perfusion-weighted MR imaging:initial experience显示文摘 | Lee SK Kim DI Jeong EK | 2003 | AJNR Am J Neuroradiol2003，24，4： | 1 |
| 13 | A novel chemokine,Leukotactin-1,induces chemotaxis,pro-atherogenic cytokines,and tissue factor expression in atherosclerosis显示文摘 | Lee WH Kim SH Jeong EM Choi YH Kim DI Lee B | 2002 | Atherosclerosis2002，161，2： | 1 |
| 14 | Risk factors for recurrence of primary bile duct stones after endoscopic biliary sphincterotomy显示文摘 | Kim DI Kim MH Lee SK | 2001 | Gastrointest Endosc2001，54，1： | 1 |
| 15 | Posterior instrumentation using for the treatment of tuberculosis of the lower lumbar spine 显示文摘 | Kim DI Yun YH Moon SH | 2004 | Spine2004，29，13： | 1 |
| 16 | Endoscopic hemostasis in sphincterotomy-induced hemorrhage:its efficacy and safety显示文摘 | Kim HJ Kim MH Kim DI | 1999 | Endoscopy1999，31，6： | 1 |
| 17 | Paraglottic space in supracricoid laryngectomy显示文摘 | Kim MS Sun DI Park KH eta| | 2002 | Arch Otolaryngol Head Neck Surg2002，128，3： | 1 |
| 18 | Endoscopic hemostasis in sphincterotomy-induced hemorrhage= its efficacy and safely显示文摘 | Kim HJ Kim MH Kim DI | 1999 | Endoscopy1999，31，6： | 1 |
| 19 | Tramadol reduces the sweating, vasoconstriction, and shivering threshold 显示文摘 | DE wrITE J KIM JS SESSLER DI | 1998 | Anesth Analg1998，87，1： | 1 |
| 20 | Influence of overweight and obesity on upper endoscopic findings 显示文摘 | Kim HJ Yoo TW Park DI | 2007 | Journal of Gastroenterology and Hepatolgy2007，22，4： | 1 |
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