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	题名	作者	年代	出处	被引量
1	Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.	ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu	2003	Asian Journal of Andrology2003，5，1：	38
2	预处理对动脉瘤性蛛网膜下腔出血病人脑血管痉挛的影响显示文摘背景最新实验证据表明:预处理能引起机体对抗脑血管痉挛的内源性保护机制。目的探讨在动脉瘤性蛛网膜下腔出血(aSAH)病人体内是否也存在这种内源性保护机制。方法回顾性分析一组多中心aSAH病人的缺血性预处理刺激情况:包括病人已存在狭窄闭塞性脑血管疾病和(或)脑梗死;	Kim YW Zipfel GJ Ogilvy CS 郭玉慧周静	2014	中国微侵袭神经外科杂志2014，19，4：	11
3	Microalbuminuria is associated with the insulin resistance in the Korean population显示文摘	Kim YZ Kim C Choi CS	2001	Diabetes Res Clin Pract2001，52，：	2
4	Ectopic bone formation associated with recombinant human bone morphogenetie proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers显示文摘	Kim CS Kim JI Kim J	2005	Biomaterials2005，26，15：	1
5	Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular disease relative risk using this data in type 2 diabetes patient显示文摘	Kim CS Kim HJ Won YJ	2006	Diabetes Research and Clinical Practice2006，72，2：	1
6	New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid显示文摘	Kim EK Park CS Chung WY	2002	AJR2002，178，：	1
7	Characterization of late-onset citrul-Hnemia 1 in a Korean patient:confirmation by argininosuccinate synthetase gene mutation analysis显示文摘	Kim IS Ki CS Kim JW	2006	J Biochem Mol Biol2006，39，4：	1
8	Effectiveness of biofeedbacktherapy in the treatment of anterior resection syndrome afterrectal cancer surgery显示文摘	Kim KH Yu CS Yoon YS	2011	Dis Colon Rectum2011，54，9：	1
9	Growth-associated synthesis of recombinant human glucagon and human growth hormone in high-cell-density cultures of Escherichia coli显示文摘	Shin CS Hong MS Kim DY	1998	Appl Microbiol Biotechnol1998，49，：	1
10	Inhibition of alpha - glucosidase and amylase by luteolin, a flavonoid显示文摘	Kim JS Kwon CS Son KH	2000	Biosci Biotechnol Biochem2000，64，11：	1
11	Effects of beta-toxin of Staphylococcus aureus on ciliary activity of nasal epithelial cells显示文摘	Kim CS Jean SY Min YG	2000	Laryngoscope2000，110，12：	1
12	Platelet endothelial cell adhesion molecule-1 expression modulates endothelial cell migration in vitro显示文摘	Kim CS WangT Madri JA	1998	Lab Invest1998，78，：	1
13	Antiproliferative effect of chitosan-added kimchi in HT-29 human colon carcinoma cells 显示文摘	Kong CS Bahn YE Kim BK	2010	J Med Food2010，13，1：	1
14	High incidence of post-operative bowel obstruction in newborns and infants显示文摘	Young JY Kim DS Muratore CS	2007	J PediatrSurg2007，42，6：	1
15	Mismatch repair status in sporadic colorectal cancer: immunohistochemistry and microsatellite instability analyses显示文摘	Yoon YS Yu CS Kim TW	2011	J Gastroenterol Hepa- tol2011，26，12：	1
16	Positioning of a double-lumen endobron- chial tube without the aid of any instruments:an implication for e- mergency management 显示文摘	Bahk JH Lim YJ Kim CS	2000	J Trauma2000，49，5：	1
17	Radiation dose reduction with the adaptive statistical iterative reconstruction (ASIR) technique for chest CT in children: an intra-individual comparison显示文摘	Lee SH Kim MJ Yoon CS	2012	Eur J Ra- diol2012，81，9：	1
18	Hyperventilation-induced limb shaking TIA in Moyamoya disease显示文摘	Kim HY Chung CS Lee J	2003	Neurology2003，60，1：	1
19	Efficacy of 3-dimensional endoreetal uhrasonography compared with conventional uhrasonography and computed tomography in preoperative rectal cancer staging显示文摘	Kim JC Kim tlC Yu CS	2006	Am J Surg2006，192，1：	1
20	Cellular and molecular remodeling in a heart failure model treated with the beta-blocker carteolol显示文摘	Kim CS Hajjar RI	1999	Am J Physiol1999，276，4：	1

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