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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Social factor in psychopathology:stress social support and coping process显示文摘 | | 1985 | Ann Rev Psychol1985，36，： | 1 |
| 3 | Circulating Platelets show increased activation in Patients with acute cerebral ischemia显示文摘 | ZellerJ A TsehoPee D Kessler C | 1999 | Thromb Haemost1999，81，： | 1 |
| 4 | Thrombosis of the right vein of Labbe: radiological and clinical findings 显示文摘 | Dorndorf D Wessel K Kessler C | 1993 | Neuroradiology1993，35，3： | 1 |
| 5 | The apolipoprotein E and betafibrinogen G/A - 455 gene polymorphisms are associated with ischemic stroke involving large - vessel disease显示文摘 | Kessler C Spitzer C Stauske D | 1997 | Arterlo-scler Thromb Vase Biol1997，17，： | 1 |
| 6 | Successful therapy of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient 显示文摘 | HERBRECHT R KESSLER R KRAVANJA C | 2004 | Heart Lung Transplant2004，23，12： | 1 |
| 7 | The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)显示文摘 | Kessler R C Berglund P Demler O | 2003 | JAMA2003，289，23： | 1 |
| 8 | Seasonal variations in inflammatory responses to sepsis and stress in mice 显示文摘 | Kiank C Koerner P Kessler W | 2007 | Crit Care Med2007，35，10： | 1 |
| 9 | Seasonal varia- tions in inflammatory responses to sepsis and stress in mice 显示文摘 | KIANK C KOERNER P KESSLER W | 2007 | Crit Care Med2007，35，10： | 1 |
| 10 | The Effects of Chronic Medical Conditions on Work Loss and Work Cutback显示文摘 | Kessler R C Miekelson K D | 2001 | Journal of Occu- pational and Environmental Medicine2001，43，3： | 1 |
| 11 | Lifetime cooecurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the national comorbidity survey 显示文摘 | Kessler R C Crum R M Warner L A | 1997 | Archives of General Psychiatry1997，54，： | 1 |
| 12 | Cilengitide: the first anti-anglogenie small molecule drug candidate design, syn- thesis and clinical evaluation 显示文摘 | Mas-Moruno C Rechenmacher F Kessler H | 2010 | Antieancer Agents Med Chem2010，10，10： | 1 |
| 13 | Mood disorders in children and adolescents: an epidemiologic perspective 显示文摘 | Kessler R C Avenevoli S and Merikangas KR | 2001 | Biological Psychiatry2001，49，12： | 1 |
| 14 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 15 | Insomnia and the performance of US workers: results from the America insomnia survey显示文摘 | Kessler RC Berglund PA Coulouvrat C | 2011 | Sleep2011，34，9： | 1 |
| 16 | Underreporting of blood and body fluid exposures among health care studentsand trainees in the acute care setting:A 2007 survey 显示文摘 | Kessler C S McGuinn M Spec A | 2011 | Am J Infect Control2011，39，2： | 1 |
| 17 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 18 | Interface study of CuInSe2/ZnO and Cu (In, Ga) Se2/ZnO devices using ALD ZnO buffer layers显示文摘 | Platzer-Bjorkman C Lu J Kessler J | 2003 | Thin Solid Films2003，，： | 1 |
| 19 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication显示文摘 | Kessler R C Berglund P Demler O Jin R Merikangas K R Walters E E | | 0，，62： | 1 |
| 20 | The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)显示文摘 | Kessler R C Berglund P Demler O | 2003 | JAMA2003，289，23： | 1 |
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