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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | β- ( 1 →3,1 →4 ) oat glucan enhances resistance to Eimeria vermiformis infection in immunosuppressed mice显示文摘 | Heuiyun C Estrada A Kessel A V | 1997 | International Journal for Parasitology1997，27，3： | 1 |
| 3 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 4 | Tracing lSN through landscapes: Potential uses and precautions显示文摘 | BEDARD-HAUGHN A VAN GROENIGEN J W VAN KESSEL C | 2003 | Jourba: o{ Hydrology2003，272，： | 1 |
| 5 | Masked t(X;18) (p11;q11) in a biphasic synovial sarcoma revealed by FISH and RT-PCR 显示文摘 | Geurts van Kessel A de Bruijn D Hermsen L | 1998 | Genes Chromosomes Cancer1998，23，2： | 1 |
| 6 | Savoy: Absorption of methionine and 2-hydroxy-4-methylthiobutoanic acid in conventional and germ-free chickens显示文摘 | Drew M D Van Kessel A G Maer z D D | 2003 | Poultry Science2003，82，7： | 1 |
| 7 | Neuropilins and semaphor- ins-from angiogenesis to autoimmunity 显示文摘 | Vadasz Z Attias D Kessel A | 2010 | Autoimmun Rev2010，9，12： | 1 |
| 8 | A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia显示文摘 | de Klein A van Kessel AG Grosveld G | 1982 | Nature1982，300，5894： | 1 |
| 9 | A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelo- cytic leukaemia 显示文摘 | de Klein A van Kessel AG Grosveld G | 1982 | Nature1982，300，5894： | 1 |
| 10 | Leflunomide in systemic lupus erythematosus显示文摘 | Kessel A Toubi E | 2002 | Harefuah2002，141，35： | 1 |
| 11 | In vitro fibre fermentation of feed ingredients with varying fermentable carbohydrate and protein levels and protein synthesis by colonic bacteria isolated from pigs 显示文摘 | Jha R Bindelle J Van Kessel A | 2011 | Anita Feed Sci Teehnol2011，165，3： | 1 |
| 12 | Upstairs walking speed dis- tributions on a long stairway 显示文摘 | Kretz T Grtinebohm A Kessel A | 2008 | Safety Science2008，，： | 1 |
| 13 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 14 | Linking Theory and Practice: Changing the Pedagogy of Teacher Education 显示文摘 | Korthagen F A Kessels J P A | 1999 | Educational Researcher1999，，5： | 1 |
| 15 | Kinetics of colour change of raspberry, sweet (Prunus avium) and sour (Prunus cerasus) cherries preserves packed in glass containers: light androom temperature effects显示文摘 | Ochoa M R Kesseler A G Michelis A D | 2001 | Journal ofFood Engineering2001，49，1： | 1 |
| 16 | Immuno - modulatory activities of oat beta - glucan in vitro and in vivo 显示文摘 | Estrada A Yun CH Van Kessel A | 1997 | Microbiol Immunol1997，41，： | 1 |
| 17 | Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients 显示文摘 | Toubi E Kessel A Avshovich N | 2004 | Allergy2004，59，8： | 1 |
| 18 | Human CD19 (+)CD25(high) B regulatory cells suppress proliferation of CD4 (+) T cells and enhance Foxp3 and CTLA-4 expression in T- regulatory cells显示文摘 | Kessel A Haj T Peri R | 2012 | Autoimmun Rev2012，11，9： | 1 |
| 19 | The role of T regulatory cells in human sepsis显示文摘 | Kessel A Bamberger E Masalha M | | 0，，3： | 1 |
| 20 | The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus显示文摘 | Toubi E Kessel A Rosner I | | 0，，： | 1 |
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