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| 1 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 2 | Sirolimus plus sorafenib in treating HCC recurrence after liver transplantation: A case report显示文摘A case of hepatocellular carcinoma (HCC) with pulmonary recurrence after liver transplantation for HCC is presented in this report. The patient showed disease progression on sorafenib therapy demonstrated by computed tomography scans as well as serial serum α-fetoprotein (AFP) elevation. After his immunosuppression therapy was successfully transitioned to sirolimus and a continuation of sorafenib, he achieved partial remission based on RECIST criteria and normalization of AFP. Mammalian target of rapamycin inhibitors including sirolimus alone or in conjunction with sorafenib may be useful in the treatment of post transplant HCC. | Kermit V Speeg William Kenneth Washburn Glenn Halff | 2010 | World Journal of Gastroenterology2010，16，43： | 2 |
| 3 | Ankle Fractures in the Elderly: What You Get Depends on Where You Live and Who You See显示文摘 | Kenneth J Koval Jon Lurie Weiping Zhou Michael B Sparks Robert V Cantu Scott M Sporer James Weinstein | 2005 | Journal of Orthopaedic Trauma2005，，9： | 2 |
| 4 | COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention 显示文摘 | Mary C C Kenneth J O John V R | 2012 | Biochim Biophys Acta2012，1825，1： | 1 |
| 5 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 6 | The effect of extracellular ice and cryoprotective agenis on the water permeability parameters of human sperm plasma membrane during freezing 显示文摘 | RAMACHANDRA V D DAVID J S KENNETH P R | 2000 | Human Reproduction2000，15，5： | 1 |
| 7 | Finding the core point in a fingerprint显示文摘 | Kameswara Rao C V Balck Kenneth | 1978 | IEEE Transactions on Computers1978，27，1： | 1 |
| 8 | Subzero water permeability parameters of mouse spermatozoa in the presence of extraceUular ice and cryoprotective agents 显示文摘 | RAMACHANDRA V D DAVID J S KENNETH P R | 1999 | Biology of Reproduction1999，61，： | 1 |
| 9 | Late Cretaceous and Cenozoic sea level estimates: Back stripping analysis of borehole data, onshore New Jersey显示文摘 | William A V S Michelle A K Kenneth G M | 2004 | Basin Re search2004，16，： | 1 |
| 10 | Characterization of a new lipopeptide surfactant produced by thermotolerant and halotol erant subsurface Bacillus licheniformis BASS0显示文摘 | YAKIMOV M KENNETH N WRAY V | 1995 | Applied and Environmental Microbiology1995，61，5： | 1 |
| 11 | The ice test versus the rest test in myasthenia gravis显示文摘 | Kenneth C Kubis Helen V Danesh-Meyer Peter J Savino Robert C Sergott | 2000 | Ophthalmology2000，，11： | 1 |
| 12 | ACC/AHA/ESC- 2006 Guidelines for themanagement of patients with atrial fibrillation 显示文摘 | Fuster V Kenneth A | 2006 | Circulation2006，114，： | 1 |
| 13 | The phanerozoic record of global sea-level change显示文摘 | KENNETH G MILLER MICHELLE A KOMINZ JAMES V BRO-WNING | 2005 | Science2005，，310： | 1 |
| 14 | Environmental magnetism: past, present, and future 显示文摘 | KENNETH L V ANDREW P R | 1995 | Journal of Geophysical Research1995，100，： | 1 |
| 15 | Fate of fumonisins during the production of flied tortilla chips 显示文摘 | Kenneth A V Stephen M P Filmore I M | 2001 | Journal of Agriculture Food Chemistry2001，49，6： | 1 |
| 16 | A Potential Field Model Using Generalized Sigmoid Functions显示文摘 | Jing Ren Kenneth A Mclsaac Rajni V Patel | 2007 | IEEE Transactions on Systems Man and Cybernetics--part B Cybernetics2007，37，2： | 1 |
| 17 | Azides:their preparation and synthetic uses显示文摘 | Eric F V S Kenneth T | 1988 | Chem Rev1988，88，： | 1 |
| 18 | Adaptive ladar receiver for multi-spectral imaging 显示文摘 | KENNETH J MOHAN V SONG X | 2001 | Proc SPIE2001，4377，： | 1 |
| 19 | Applications of ionic liquids in the chemical industry 显示文摘 | Natalia V P Kenneth R S | 2008 | Chemical Society Reviews2008，37，： | 1 |
| 20 | The ice test,versus the rest test in myasthenia gravis显示文摘 | Kenneth C Kubis MD Helen V | 2000 | Ophthalmology2000，11，： | 1 |
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