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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Direct dating of sulfides by Rb-Sr:Acritical test using the Polaris Mississippi Valley-type Zn-Pb deposit显示文摘 | Christensen J N Halliday A N Kenneth E L Roderick N R and Stephen E K | | 0，，： | 1 |
| 3 | Achieving relationship marketing effectiveneas in business-to-busineas exchanges显示文摘 | ROBERT P W LISA'S K KENNETH R | 2008 | Journal of the Acadmy of Science Sunmmer2008，36，2： | 1 |
| 4 | Simulation studies of 4 MV X-ray spectral reconstruction by numerical analysis of transmission data显示文摘 | HUANG P H KENNETH R K BENGT E B | 1982 | Med Phys1982，9，： | 1 |
| 5 | ABCG2: A perspective 显示文摘 | ROBERT W R KENNETH K K ORSOLYA P | 2009 | Advanced Drug Delivery Reviews2009，61，1： | 1 |
| 6 | Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL显示文摘 | Weerapan Khovidhunkit Philippe N Duchateau Katalin F Medzihradszky Arthur H Moser Josefina Naya-Vigne Judy K Shigenaga John P Kane Carl Grunfeld Kenneth R Feingold | 2004 | Atherosclerosis2004，，1： | 1 |
| 7 | Mandatory steroid testing of high school athletes:A synthesis of state ini- tiatives and federal constitutional rights显示文摘 | KENNETH J S KEITH M C SHANTEL R K | 2012 | J Legal Aspects Sport2012，，21： | 1 |
| 8 | Recent pro- gress in the understanding of the structure-fuetion re- lationships o{ the globular head regions of Clq 显示文摘 | Kishore U Mihaela S K Kenneth B M R | 2002 | Immunobiol2002，205，45： | 1 |
| 9 | Estrogen receptor knockout mice as a model for endocrine research显示文摘 | Vickie R Walker Kenneth S K | 2004 | ILAR Journal2004，45，45： | 1 |
| 10 | Biology and thera- peutic potential of hydrogen sulfide and hydrogen sul- fide - releasing chimeras 显示文摘 | KHOSROW K KENNETH R O | 2013 | Biochemical Pharmacol- ogy2013，85，5： | 1 |
| 11 | The materials chemistry of porphyrlns and metallopor- phyfins显示文摘 | Kenneth S Suslick Neal A R Margaret E K | 2000 | J Porphyrins Phthalocyanines2000，4，4： | 1 |
| 12 | Sorption dynamics of hydrophobic pollutants in sediment suspensions显示文摘 | Samuel W K Kenneth R M | 1985 | Environmental Toxicology and Chemistry1985，4，4： | 1 |
| 13 | DNA polymorphisms amplified by arbitrary primers are useful as genetic markers显示文摘 | JOHN G K W ANNE R K KENNETH J L | 1990 | Nucleic Acids Research1990，18，22： | 1 |
| 14 | NOSH-aspirin( NBS- 1120 ), a novel nitric oxide-and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth < i > in vitro and in a xenograft mouse model显示文摘 | MITALI C RAVINDER K KENNETH R O | 2012 | Biochemical and Bio- physical Research Communications2012，419，3： | 1 |
| 15 | A role for the adenomatous polyposis coil protein in chromosome segregation 显示文摘 | KENNETH B K AURORA A B JASON R S | 2001 | Nat Cell Biol2001，3，4： | 1 |
| 16 | DNA polymorphisms amplified by arbitrary primers are useful as genetic markers显示文摘 | John G K Anne R K Kenneth J L | 1990 | Nuclei Acids Research1990，18，22： | 1 |
| 17 | Sliding wear and fretting wear of diamondlike carbon-based, functionally graded nanocomposite coatings显示文摘 | K Miyoshi B Pohlchuck Kenneth W Street J S Zabinski J H S ers A A Voevodin R L C Wu | | 0，，： | 1 |
| 18 | Machine learning, medical diagnosis, and biomedical engineering research-commen- tary显示文摘 | Kenneth R Robert K Joseph | 2014 | Biomedical Engineering OnLine2014，13，1： | 1 |
| 19 | Issues and Implications in the Selection of Blood Glucose Monitoring Technologies显示文摘 | Kenneth E R Ernest K J | 1999 | Diabetes Technol Ther1999，1，1： | 1 |
| 20 | Technetium-99m galaetosyl-neoglycoalbumin: preparation and preclinical studies 显示文摘 | DAVID R V ROBERT C S KENNETH A K | 1985 | J Nucl Med1985，26，10： | 1 |
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