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| 1 | Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy显示文摘AIM To compare the efficacy and safety of cold snare polypectomy(CSP) and hot forceps biopsy(HFB) for diminutive colorectal polyps.METHODS This prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection(endoscopic evaluation) and complete resection rates(pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn't routinely performed.RESULTS Two hundred eight patients were randomized into the CSP(102), HFB(106) and 283 polyps were evaluated(CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3%(147/148) vs 80.0%(108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4%(119/148) vs 47.4%(64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6%(13/148) vs 8.1%(11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6%(71/135) vs 1.3%(2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP(7), HFB(2).CONCLUSION CSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required. | Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano Takaaki Chikugo Yasutaka Chiba Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，2： | 20 |
| 2 | Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers显示文摘AIM:To prospectively compare the healing rates of endoscopic submucosal dissection(ESD)-induced ulcers treated with either a proton-pump inhibitor(PPI)or rebamipide.METHODS:We examined 90 patients with early gastric cancer who had undergone ESD.All patients were administered an intravenous infusion of the PPI lansoprazole(20 mg)every 12 h for 2 d,followed by oral administration of lansoprazole(30 mg/d,5 d).After7-d treatment,the patients were randomly assigned to 2 groups and received either lansoprazole(30 mg/d orally,n=45;PPI group)or rebamipide(300 mg orally,three times a day;n=45;rebamipide group).At 4and 8 wk after ESD,the ulcer outcomes in the 2 groups were compared.RESULTS:No significant differences were noted in patient age,underlying disease,tumor location,Helicobacter pylori infection rate,or ESD-induced ulcersize between the 2 groups.At both 4 and 8 wk,the healing rates of ESD-induced ulcers were similar in the PPI-treated and the rebamipide-treated patients(4 wk:PPI,27.2%;rebamipide,33.3%;P=0.5341;8 wk:PPI,90.9%;rebamipide,93.3%;P=0.6710).At 8 wk,the rates of granulation lesions following ulcer healing were significantly higher in the PPI-treated group(13.6%)than in the rebamipide-treated group(0.0%;P=0.0103).Ulcer-related symptoms were similar in the2 treatment groups at 8 wk.The medication cost of 8-wk treatment with the PPI was 10945 yen vs 4889 yen for rebamipide.No ulcer bleeding or complications due to the drugs were observed in either treatment group.CONCLUSION:The healing rate of ESD-induced ulcers was similar with rebamipide or PPI treatment;however,rebamipide treatment is more cost-effective and prevents granulation lesions following ulcer healing. | Masaki Takayama Shigenaga Matsui Masanori Kawasaki Yutaka Asakuma Toshiharu Sakurai Hiroshi Kashida Masatoshi Kudo | 2013 | World Journal of Gastroenterology2013，19，34： | 15 |
| 3 | Two-Dimensional Super High Density Multi-Fiber Connector显示文摘We have developed 32-fiber and 60-fiber super high density multi fiber connector. This 32-fiber connector can be applicable for single-mode fiber and 60-fiber connector for multi-mode fiber. We have also established PC (physical contact) connection technology by optimizing polishing condition and clamping force. | Takashi Shigenaga Katsuki Suematsu Masao Shinoda Takayuki Ando | 2003 | 光学学报2003，23，S1： | 6 |
| 4 | Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection显示文摘BACKGROUND Risk factors for local recurrence after polypectomy, endoscopic mucosal resection(EMR), and endoscopic submucosal dissection(ESD) have not been identified.Additionally, the appropriate interval for endoscopic surveillance of colorectal tumors at high-risk of local recurrence has not been established.AIM To clarify the clinicopathological characteristics of recurrent lesions after endoscopic colorectal tumor resection and determine the appropriate interval.METHODS Three hundred and sixty patients(1412 colorectal tumors) who underwent polypectomy, EMR, or ESD and received endoscopic surveillance subsequently for more than one year to detect local recurrence were enrolled in this study. The clinicopathological factors associated with local recurrence were determined via univariate and multivariate analyses.RESULTS Local recurrence was observed in 31 of 360(8.6%) patients [31 of 1412(2.2%)lesions] after colorectal tumor resection. Piecemeal resection, tumor size of more than 2 cm, and the presence of villous components were associated with colorectal tumor recurrence after endoscopic resection. Of these three factors, the piecemeal resection procedure was identified as an independent risk factor for recurrence. Colorectal tumors resected into more than five pieces were associated with a high risk of recurrence since the average period from resection torecurrence in these cases was approximately 3 mo. The period to recurrence in cases resected into more than 5 pieces was much shorter than that in those resected into less than 4 pieces(3.8 ± 1.9 mo vs 7.9 ± 5.0 mo, P < 0.05).CONCLUSION Local recurrence of endoscopically treated colorectal tumors depends upon the outcome of first endoscopic procedure. Piecemeal resection was the only significant risk factor associated with local recurrence after endoscopic resection. | Yoriaki Komeda Tomohiro Watanabe Toshiharu Sakurai Masashi Kono Kazuki Okamoto Tomoyuki Nagai Mamoru Takenaka Satoru Hagiwara Shigenaga Matsui Naoshi Nishida Naoko Tsuji Hiroshi Kashida Masatoshi Kudo | 2019 | World Journal of Gastroenterology2019，25，12： | 4 |
| 5 | Angiopoietin like pro-tein 4 expression is decreased in activated macrophages 显示文摘 | Feingold KR Shigenaga JK Cross AS | 2012 | BiochemBiophys Res Commun2012，421，3： | 1 |
| 6 | Urinary 8-hydroxy-2' -deoxyguanosine as a biological marker of in vivo oxidative DNA damage显示文摘 | Shigenaga M K Gimeno C J Ames B N | 1989 | Proc Natl Aead Sci USA1989，86，24： | 1 |
| 7 | Inflammation stimulates the expression of PCSK9 显示文摘 | Feingold KR Moser AH Shigenaga JK | 2008 | Biochem Biophys Res Commun2008，374，2： | 1 |
| 8 | Novel regulatoryeffect of angiotensinⅡtype 1 receptor-interacting moleculeon vascular smooth muscle cells显示文摘 | Azuma K Tamura K Shigenaga A | 2007 | Hypertension2007，50，5： | 1 |
| 9 | Gamma-tocopherol traps mutagenic electrophiles such as NOx and complements alpha-tocopherol: physiological implications显示文摘 | Christen S Woodall AA Shigenaga MK | 1997 | Proc Natl Acad Sci USA1997，94，7： | 1 |
| 10 | Oxidants, Antioxidants, and the Degenerative Diseases of Aging显示文摘 | AMES BN SHIGENAGA MK HAGEN TM | 1993 | Proc Natl Acad Sci USA(S1091-6490)1993，90，： | 1 |
| 11 | Tumornecrosis factor and interleukin 1 decrease RXRalpha,PPARalpha,PPARgamma,LXRalpha,and the coactivatorsSRC-1,PGC-1 alpha, and PGC-lbeta in liver cells 显示文摘 | Kim MS Sweeney TR Shigenaga JK | 2007 | Metabolism2007，56，2： | 1 |
| 12 | Oxidants, antioxidants, and the degeneration disease of the aging显示文摘 | Ames B N Shigenaga M K Hagen T M | 1993 | Pro Natl Acad Sci USA1993，90，： | 1 |
| 13 | Oxidative damage and mitochondrial decay in aging显示文摘 | Shigenaga M K Hagen T M Ames B N | 1994 | Proc Nat Acad Sci USA1994，91，10： | 1 |
| 14 | Oxidants, antioxidants, and the degenerative diseases of aging 显示文摘 | Ames B N Shigenaga M K Hagen T M | 1993 | Proc Natl Acad Sci USA1993，90，17： | 1 |
| 15 | Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats显示文摘 | Liu J Wang X Shigenaga MK | 1996 | FASEB J1996，10，13： | 1 |
| 16 | (1993)Oxidants,antioxidants and the degenerative diseases of aging 显示文摘 | Ames BN Shigenaga MK Hagen TM | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
| 17 | Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver显示文摘 | Beigneux A Moser AH Shigenaga JK | 2003 | Am J Physiol Endocrinol Metab2003，284，： | 1 |
| 18 | Infection and inflam- mation decrease apolipoprotein M expression 显示文摘 | Feingold KR Shigenaga JK Chui LG | 2008 | Atherosclerosis2008，199，1： | 1 |
| 19 | Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of routine macrophages by toll-like receptor agonists 显示文摘 | Kazemi M R McDonald C M Shigenaga J K | 2005 | Arterioscle Thromb Vasc Biol2005，25，： | 1 |
| 20 | Oxidants,Antioxidants and the Degenerative Diseases of Aging显示文摘 | Ames B N Shigenaga M K Hagen T M | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
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