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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Sliding wear and fretting wear of diamond-like carbon-based functionally graded nano-composite coatings显示文摘 | Miyoshi K Pohlchuck B Street Kenneth W | 1999 | Wear1999，2252，29： | 1 |
| 3 | Soft rot erwiniae:from genes to genomes显示文摘 | Ian K Kenneth S B Maria C H | 2002 | Mol Plant Pathol2002，，4： | 1 |
| 4 | Simulation studies of 4 MV X-ray spectral reconstruction by numerical analysis of transmission data显示文摘 | HUANG P H KENNETH R K BENGT E B | 1982 | Med Phys1982，9，： | 1 |
| 5 | The Aspirin of the new millennium: Cox-2 inhibitor 显示文摘 | Nvtejs B Kenneth K Wany | 2000 | Mayo Clinic Proceedings2000，75，10： | 1 |
| 6 | Renal corpuscular hydrodynamics: Digital computer simulation显示文摘 | Kenneth Steven Steffen Str?b?k | 1974 | Pflügers Archiv European Journal of Physiology1974，，4： | 1 |
| 7 | Do vanadate polyanions inhibit phosphotransferase enzymes显示文摘 | Donald W B Kenneth K Maho N | | 0，，： | 1 |
| 8 | An electrochemical impedance spectroscope method for prediction of the state of charge of nickel-metal hydridebattery at open circuit and during discharge显示文摘 | KENNETH B MIKAEL K GORAN L | 1998 | Journal of Power Sources1998，72，： | 1 |
| 9 | Recent pro- gress in the understanding of the structure-fuetion re- lationships o{ the globular head regions of Clq 显示文摘 | Kishore U Mihaela S K Kenneth B M R | 2002 | Immunobiol2002，205，45： | 1 |
| 10 | Microwave device: carbon nanotubes as cold cathodes 显示文摘 | Kenneth B K Teo Eric Minonx Ludovic Hudanski | 2005 | Nature2005，437，13： | 1 |
| 11 | Superhydrophobic carbron narbon nanotube forests显示文摘 | Kenneth K S Jose Bico Kenneth B K T | 2003 | Nano Letters2003，3，12： | 1 |
| 12 | Soft rot erwiniae:from genes to genomes显示文摘 | IAN K KENNETH S B MARIA C H | 2002 | Mol Plant Pathol2002，，4： | 1 |
| 13 | Soft rot erwiniae: from genes to genomes显示文摘 | Ian K Kenneth S B Mariach | 2002 | Mol Plant Pathol2002，4，： | 1 |
| 14 | Best managemcnt practices for water quality improvement in the Lake Okcechobee Watershed 显示文摘 | Bottcher A B Tremwel Terry K Campbell Kenneth L | 1995 | Ecol Eng1995，，5： | 1 |
| 15 | Mouse Forkhead L2(F0XL2) maintains repression of FSH-dependent genes in the granu-losa cell显示文摘 | Fang-Ting K Kenneth F Ikuku B B ei al | 2012 | Reproduction2012，144，4： | 1 |
| 16 | Regulation of HMG-CoA reductase activity in plants显示文摘 | Bruce A S Graeiela M B Kenneth L K | 1994 | J Lipid Res1994，35，7： | 1 |
| 17 | A role for the adenomatous polyposis coil protein in chromosome segregation 显示文摘 | KENNETH B K AURORA A B JASON R S | 2001 | Nat Cell Biol2001，3，4： | 1 |
| 18 | Sliding wear and fretting wear of diamondlike carbon-based, functionally graded nanocomposite coatings显示文摘 | K Miyoshi B Pohlchuck Kenneth W Street J S Zabinski J H S ers A A Voevodin R L C Wu | | 0，，： | 1 |
| 19 | Localization of more sources thansensors via joint-sparse beyasian learning显示文摘 | Ozgur B Kenneth K D | 2014 | IEEE SignalProcessing Letters2014，21，2： | 1 |
| 20 | Rapid polyether cleavage via extracellular one-electron oxidation by a brown-rot basidiomycete显示文摘 | Zohar K Wuli B Kenneth E H | 1998 | Proc Natl Acad Sci USA September1998，95，10： | 1 |
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