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| 1 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 2 | A Survey of Bitmap Index Compression Algorithms for Big Data显示文摘With the growing popularity of Internet applications and the widespread use of mobile Internet, Internet traffic has maintained rapid growth over the past two decades. Internet Traffic Archival Systems(ITAS) for packets or flow records have become more and more widely used in network monitoring, network troubleshooting, and user behavior and experience analysis. Among the three key technologies in ITAS, we focus on bitmap index compression algorithm and give a detailed survey in this paper. The current state-of-the-art bitmap index encoding schemes include: BBC, WAH, PLWAH, EWAH, PWAH, CONCISE, COMPAX, VLC, DF-WAH, and VAL-WAH. Based on differences in segmentation, chunking, merge compress, and Near Identical(NI) features, we provide a thorough categorization of the state-of-the-art bitmap index compression algorithms. We also propose some new bitmap index encoding algorithms, such as SECOMPAX, ICX, MASC, and PLWAH+, and present the state diagrams for their encoding algorithms. We then evaluate their CPU and GPU implementations with a real Internet trace from CAIDA. Finally, we summarize and discuss the future direction of bitmap index compression algorithms. Beyond the application in network security and network forensic, bitmap index compression with faster bitwise-logical operations and reduced search space is widely used in analysis in genome data, geographical information system, graph databases, image retrieval, Internet of things, etc. It is expected that bitmap index compression will thrive and be prosperous again in Big Data era since 1980s. | Zhen Chen Yuhao Wen Junwei Cao Wenxun Zheng Jiahui Chang Yinjun Wu Ge Ma Mourad Hakmaoui Guodong Peng | 2015 | Tsinghua Science and Technology2015，20，1： | 5 |
| 3 | Corrosion resistance of tannic acid,d-limonene and nano-ZrO_(2)modified epoxy coatings in acid corrosion environments显示文摘The protection of rusted carbon steel in acid corrosion environments is of great significance for equipment to keep safe operation.In this work,we presented a method to protect the rusted steel by ru st conversion treatment and epoxy coating.Tannic acid was selected as rust conversion agent.Tannic acid,D-limonene and nano-ZrO_(2)were used to improve the corrosion resistance of epoxy coatings.The Raman spectra,Xray diffraction and 3 D confocal images were used to characterize the rust conversion reaction.Ad hesion test showed that the loss of wet adhesion of the optimal coating was relatively low due to the addition of tannic acid,limonene and nano-ZrO(2).The corrosion resistance of five different coatings was investigated by scanning electron microscopy(SEM)and electrochemical analysis.Results show that after 264 h acid immersion,the low frequency resistance of the optimal coating consisting of rust conversion treatment and additives is 10^(7)Ωcm^(2),three orders magnitude higher than that of the pristine coating.Moreover,SEM indicates that the optimal coating possesses a smooth surface and an unbroken interface between substrate and coating.Accordingly,the corrosion-resistant mechanism of the hybrid coating is proposed. | Junwei Chang Zhenyu W ang En-hou Han Xinlei Liang Gang Wang Zuyao Yi Na Li | 2021 | Journal of Materials Science & Technology2021，，6： | 3 |
| 4 | Powerful supercontinuum vortices generated by femtosecond vortex beams with thin plates显示文摘We demonstrate numerically and experimentally the generation of powerful supercontinuum vortices from femtosecond vortex beams by using multiple thin fused silica plates.The supercontinuum vortices are shown to preserve the vortex phase profile of the initial beam for spectral components ranging from 500 nm to 1200 nm.The transfer of the vortex phase profile results from the inhibition of multiple filamentation and the preservation of the vortex ring with relatively uniform intensity distribution by means of the thin-plate scheme,where the supercontinuum is mainly generated from the self-phase modulation and self-steepening effects.Our scheme works for vortex beams with different topological charges,which provides a simple and effective method to generate supercontinuum vortices with high power. | Litong Xu Dongwei Li Junwei Chang Deming Li Tingting Xi Zuoqiang Hao | 2022 | Photonics Research2022，10，3： | 1 |
| 5 | Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1显示文摘 | Junwei Gao Xiaohua Wang Yongjie Chang | 2006 | Analytical Biochemistry2006，，350： | 1 |
| 6 | Development of an indirect immunofluorescence assay for PCV3 antibody detection based on capsid protein显示文摘Porcine circovirus type 3(PCV3)is a novel porcine circovirus associated with porcine dermatitis and nephritis syndrome(PDNS),reproductive failure,and multisystemic inflammation.Capsid protein(Cap)encoded by PCV3 ORF2 gene has been identified as an immunogenic protein.Currently,there is no immunofluorescence assay(IFA)available for serological diagnosis.Here,the N-terminal 33 amino acids of Cap protein were predicted to serve as a PCV3 nuclear localization signal(NLS).Two types of recombinant plasmids were constructed for recombinant protein expression in 5f9 cells by using a baculovirus expression system:plasmid rvBac-Pc for full-length Cap protein expression and rvBac-Sc for Cap protein expression with a honeybee melittin signal peptide in place of the predicted NLS sequence.Expression of the nuclear localization sequences was further analyzed by IFA.Strong and specific fluorescence signals were observed in the nucleus of rvBac-Pc-transfected cells and in the cytoplasm of rvBac-Sc-transfected cells.No cross-reactivity was observed with porcine circovirus type 2,porcine pseudorabies virus,classical swine fever virus,or porcine reproductive and respiratory syndrome virus.In summary,we developed two fluorescence detection modes for Cap protein that can be used to detect PCV3 antibodies.This method is suitable for the diagnosis and epidemiological investigation of PCV3.This study provides a reliable detection method for monitoring PCV3 antibody level in pigs in the future. | Lun Yao Chang Li Junwei Wang Yufang Cheng Ahmed H.Ghonaim Qi Sun Xuexiang Yu Weijie Niu Shengxian Fan Qigai He | 2021 | Animal Diseases2021，1，2： | 0 |
| 7 | Powerful supercontinuum vortices generated by femtosecond vortex beams with thin plates: publisher’s note显示文摘 | Litong Xu Dongwei Li Junwei Chang Deming Li Tingting Xi Zuoqiang Hao | 2022 | Photonics Research2022，10，4： | 0 |
| 8 | Efficacy of electroacupunture at Zusanli(ST36)on jumping-injured muscle based on transcriptome sequencing and genes analysis显示文摘METHODS:In the present study,female SpragueDawley rats were randomly divided into four groups with 6 of each,including normal control group(NC),jumpinginduced muscle injury model group(JI),JI with electroacupuncture stimulation treatment group(EA),and JI with non-electroacupuncture stimulation group(NEA).Transmission electron microscopy,transcriptome sequencing and analysis,prediction of protein interaction networks,real-time polymerase chain reaction verification,and Western blotting were performed on the gastrocnemius muscle of ipsilateral lower limbs.RESULTS:The structural repair of injured gastrocnemius myofibers following jumping training in EA rats was better than that of NEA rats.A total of 136 genes were differentially expressed in EA rats relative to JI rats,with 55 genes upregulated and 81 genes downregulated.According to results of transcriptome analysis,and prediction of protein mutual interaction by the online STRING database,Heat shock protein beta-7(Hspb7)and myozenin2(Myoz2)genes were targeted.Expressions of Hspb7 and Myoz2 mRNAs were increased in EA rats relative to JI rats(P<0.05).The expression of Hspb7 protein was upregulated in EA rats relative to that in NC,JI,and NEA rats(P<0.01,<0.05,and<0.05,respectively).The expression of Myoz2 protein was upregulated in EA rats relative to that in NC and JI rats(both P<0.01,respectively).CONCLUSIONS:The present results suggest that electroacupuncture stimulation at Zusanli(ST36)could improve muscle healing following jumping-induced muscle injury,owing to the upregulation of Hspb7 and Myoz2 proteins. | HAN Rui CHANG Junzhao LIU Qianqian LIU Haitao LI Junwei | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 0 |
| 9 | Causal relationships between chronotype and risk of multiple cancers by using longitudinal data and Mendelian randomization analysis显示文摘Dear Editor,Cancer is the second leading cause of death worldwide,and the cancer situation is becoming more complicated(Zhou et al.,2022).The International Agency for Research on Cancer(IARC)Monographs Working Group classified night shift work as probably carcinogenic(Group 2A)to humans in2019(Ward et al.,2019). | Shanshan Tian Longtao Huangfu Sizhi Ai Junwei Zheng Le Shi Wei Yan Ximei Zhu Qianwen Wang Jiahui Deng Yanping Bao Suhua Chang Lin Lu | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 10 | An iron-catalyzed multicomponent reaction of cycloketone oxime esters, alkenes, DABCO·(SO_(2))_(2) and trimethylsilyl azide显示文摘An iron-catalyzed four-component reaction of cycloketone oxime esters,alkenes,DABCO·(SO_(2))_(2) and tri-methylsilyl azide(TMSN_(3))is described.This multicomponent radical transformation presents excellent regio-and chemoselectivity,leading to a range of β-azidosulfones in moderate to excellent yields.In this protocol,the utilization of a sulfur dioxide surrogate of DABCO·(SO_(2))_(2) as the source of the sulfonyl group enables the reaction to proceed efficiently under mild conditions without the need for strong oxidants.Additionally,the products can be transformed intoβ-aminosulfones and other valuable sulfonyl-contain-ing nitrogen heterocycles. | Jun Zhang Junwei Wu Xiaotong Chang Peiqi Wang Jiemin Xia Jie Wu | 2022 | Organic Chemistry Frontiers2022，9，4： | 0 |
| 11 | 6-20 Development of SECRAL II Ion Source at IMP in 2016显示文摘SECRAL II is the second fully superconducting ECR ion source developed at IMP.It’s almost the duplicate of SECRAL,except for the cryogenic system[1].SECRAL II has integrated LHe recondensation system,which has the dynamic cooling capacity of more than 5 W.The main parameters of SECRAL I&II are shown in Table 1.The magnets of SECRAL II has been successfully fabricated and tested in 2015.In 2016,SECRAL II has been commissioned at 18 and 28 GHz with O and Xe ion beams,which has given very promising results. | Guo Junwei Sun Liangting Zhang Wenhui Shen Zhen Feng Yucheng Fang Xing Zhang Xuezhen Ma Hongyi Yang Yao Li Libing Chang Jianjun Wang Pengpeng Zhao Huanyu Zhao Hongwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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