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| 1 | The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis:a report of two cases显示文摘Background:IgG4-related hypertrophic pachymeningitis is a relative newly recognized and rare manifestation of IgG4-related disease,an immune-mediated fibroinflammatory tumefactive disorder.Fewer than 80 patients have been reported in the literature,and it can mimic common neurosurgical conditions.We describe the clinical presentation of two patients that were initially considered to have a subdural collection,tuberculous meningitis,and a cervical spinal meningioma,but were eventually diagnosed with this disease.Case presentation:Two ethnic Chinese men,86 and 62 years old,experienced a 4-week history of headache.Both patients had a history of autoimmune disease,namely glomerulonephritis and Grave’s disease,respectively.Magnetic resonance brain imaging revealed diffuse dural thickening with the latter patient exhibiting homogeneous and intense gadolinium-contrast enhancement.Since the 86-year-old patient also had progressive bilateral visual loss,giant cell arteritis was suspected and a 2-week course of glucocorticoid therapy was prescribed,but his symptoms failed to improve.The 62-year-old patient also had accompanying low-grade fever and was treated empirically as having tuberculous meningitis although there were no confirmatory microbiological findings.This patient further developed right hemiparesis,and additional imaging revealed a C4/5 intradural-extramedullary contrast-enhancing lesion resembling a meningioma causing cord compression.Both patients underwent neurosurgical intervention with the former undergoing a dural biopsy and the latter having the cervical lesion resected.The final diagnosis was IgG4-related hypertrophic pachymeningitis with the hallmark histological features of lymphoplasmacytic infiltration of IgG4+plasma cells,storiform fibrosis,and obliterative phlebitis.In addition,their serum IgG4 levels were elevated(i.e.,>135 mg/dL).Both patients received at least 6 months of glucocorticoid therapy while the latter also had azathioprine.Their symptoms improved significantly and recurrent lesions were not detected on follow-up imaging.Conclusions:A high index of suspicion for this condition is suggested when a male patient with a history of autoimmune disease and compatible radiological findings,experiences subacute headache that is disproportionate to the degree of dural involvement.Neurosurgeons should consider early meningeal biopsy to establish a definitive histological diagnosis in order for early effective immunosuppressive treatment to be initiated and to avoid unnecessary morbidity. | Peter Y.M.Woo Ben C.F.Ng June H.M.Wong Oliver K.S.Ng Timothy S.K.Chan Ngai-Fung Kwok Kwong-Yau Chan | 2021 | Chinese Neurosurgical Journal2021，7，4： | 2 |
| 2 | Cancer genetics fundamentals显示文摘 | June Peters Jennifer Loud Eileen Dimond | 2001 | Cancer Nursing2001，24，6： | 1 |
| 3 | Association of statin and nonsteroidal anti‐inflammatory drug use with prostate cancer outcomes: results from CaPSURE显示文摘 | Matthew S.Katz Peter R.Carroll Janet E.Cowan June M.Chan Anthony V.D’Amico | 2010 | BJU International2010，，5： | 1 |
| 4 | Physical activity and prostate gene expression in men with low-risk prostate cancer显示文摘 | Mark Jesus M. Magbanua Erin L. Richman Eduardo V. Sosa Lee W. Jones Jeff Simko Katsuto Shinohara Christopher M. Haqq Peter R. Carroll June M. Chan | 2014 | Cancer Causes & Control2014，，： | 1 |
| 5 | Impact of obesity on prostate cancer recurrence after radical prostatectomy: Data from CaPSURE显示文摘 | William W. Bassett Matthew R. Cooperberg Natalia Sadetsky Stefanie Silva Janeen DuChane David J. Pasta June M. Chan Jason W. Anast Peter R. Carroll Christopher J. Kane | 2005 | Urology2005，，5： | 1 |
| 6 | Probing the IRC+10 ° 216 circumstellar envelope using spectroscopic observations of background stars显示文摘 | Tim Kendall Nicolas Mauron June McCombie Peter Sarre | 2004 | Astrophysics and Space Science (-)2004，，3： | 1 |
| 7 | Level of Acceptability of the Instructional Guide in Physical Education 2(Advanced Swimming Skills and Life-Saving Techniques)显示文摘This descriptive study aimed to determine the level of acceptability of the Instructional Guide in Physical Education 2(Advanced Swimming Skills and Life-Saving Techniques).The respondents of the study were the content experts currently teaching PE(Physical Education)in other universities in Iloilo and Bacolod City,Philippines together with the BSMT(Bachelor of Science Marine Transportation)students who used the instructional guide throughout the duration of the study.The instrument used to evaluate the materials was adopted from Terunez(2008)and included seven evaluation criteria to include physical aspect,language,content,objectives,instructions,learning activities,and evaluation measures.The statistical tools employed were mean,standard deviation,and rank.The results of the study revealed that the level of acceptability of the instructional guide in physical aspect was“High”which means that the material was suited to the level of the intended users.No significant difference was noted in the evaluation result of the content experts and student users.It can be concluded that the development of Instructional Guide in Physical Education 2 is deemed to be highly beneficial in enhancing learning.It is recommended that this instructional material will be utilized by other maritime institutions offering courses in Advanced Swimming and Life-Saving Techniques. | Brian Gil S.Sarinas Emilie C.Coo Roderick R.Germo Marlon R.Terunez Belinda E.Gavadan Cherry Y.Jardenil June Raymund Peter V.Flores | 2021 | Journal of Shipping and Ocean Engineering2021，11，2： | 0 |
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