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| 1 | Identification of three novel noncoding RNAs from Drosophila melanogaster显示文摘三新奇小非编码的 RNA 从 D 的保存 intronicregions 被识别。由使用比较基因组学方法和分子的生物学途径的 melanogaster。Oneis 以一个 combinated 方法的新奇 snoRNA,它 snoRNAfamily 显示典型地代表 C/D 盒子的结构的特征并且为在 C2673 指导 D.melanogaster 28S rRNA 的 2''-O-methylation 拥有一个 10-nt-long rRNA 反感觉元素。另外的二是预言先锋采用已知的 miRNA 的 astem 环结构特征的 miRNAs。二 miRNAs 基因看起来有无所不在的表示侧面, ~ 23-nt RNA 抄本由北弄污检测了。我们的学习 revealed396 多种类 intronic 保存了与长度 from100 在 introns 嵌套到 500 bp 的序列(MCIS ) 。除了编码的小 RNA, MCIS 可能作为涉及基因抄写或 post-transcriptional 处理的 c/s-acting 元素工作。 | HE Hualiang ZHOU Hui XIAO Zhendong ZENG Xianfen CHEN Junyu ZHENG Tao QU Lianghu | 2006 | Chinese Science Bulletin2006，51，22： | 2 |
| 2 | Spatiotemporal Mapping of Salt Marshes in the Intertidal Zone of China during 1985-2019显示文摘This study mapped the areal extent,identified the species composition,and analyzed the changes of salt marshes in the intertidal zone of China during the period 1985–2019.With the aid of the cloud platform of the Google Earth Engine,we selected Landsat 5/8 and Sentinel-2 images and used the support vector machine classification method to extract salt marsh information for the years of 1985,1990,1995,2000,2005,2010,2015,and 2019.Seven major species of salt marshes:Phragmites australis,Suaeda spp.,Spartina alterniflora,Scirpus mariqueter,Tamarix chinensis,Cyperus malaccensis,and Sesuvium portulacastrum were identified.Our results showed that salt marshes are mainly distributed in Liaoning,Shandong,Jiangsu,Shanghai,and Zhejiang,with varying patterns of shrinking,expansion,or wavering in different places.The distribution of salt marshes has declined considerably from 151,324 ha in 1985 to 115,397 ha in 2019,a drop of 23.7%.During the same period,the area of native species has dropped 95.4%from 77,741 ha to 3,563 ha for Suaeda spp.and 45.1%from 60,511 ha to 33,193 ha for P.australis;on the contrary,the area of exotic species,S.alterniflora,has exhibited a sharp rise from just 99 ha to 67,527 ha.For the past 35 years,the driving factors causing salt marsh changes are mainly land reclamation,variations in water and sand fluxes,and interspecific competition and succession of salt marsh vegetation.These results provide fundamental reference information and could form the scientific basis for formulating policies for the conservation and utilization of salt marsh resources in China. | Guangwei Chen Runjie Jin Zhanjiang Ye Qi Li Jiali Gu Min Luo Yongming Luo George Christakos James Morris Junyu He Dan Li Hengwei Wang Li Song Qiuxuan Wang Jiaping Wu | 2022 | Journal of Remote Sensing2022，，1： | 2 |
| 3 | Achieving a sub-10 nm nanopore array in silicon by metal-assisted chemical etching and machine learning显示文摘Solid-state nanopores with controllable pore size and morphology have huge application potential.However,it has been very challenging to process sub-10 nm silicon nanopore arrays with high efficiency and high quality at low cost.In this study,a method combining metal-assisted chemical etching and machine learning is proposed to fabricate sub-10 nm nanopore arrays on silicon wafers with various dopant types and concentrations.Through a SVM algorithm,the relationship between the nanopore structures and the fabrication conditions,including the etching solution,etching time,dopant type,and concentration,was modeled and experimentally verified.Based on this,a processing parameter window for generating regular nanopore arrays on silicon wafers with variable doping types and concentrations was obtained.The proposed machine-learning-assisted etching method will provide a feasible and economical way to process high-quality silicon nanopores,nanostructures,and devices. | Yun Chen Yanhui Chen Junyu Long Dachuang Shi Xin Chen Maoxiang Hou Jian Gao Huilong Liu Yunbo He Bi Fan Ching-Ping Wong Ni Zhao | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 2 |
| 4 | Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis显示文摘Zika virus(ZIKV) infection could disrupt neurogenesis and cause microcephaly in neonates by targeting neural progenitor cells(NPCs). The tumor suppressor p53-mediated cell cycle arrest and apoptotic cell death have been suggested to be activated upon ZIKV infection, yet the detailed mechanism is not well understood. In the present study, we investigated the effects of ZIKV-encoded proteins in the activation of p53 signaling pathway and found that, among the ten viral proteins,the nonstructural protein 5(NS5) of ZIKV most significantly activated the transcription of p53 target genes. Using the immunoprecipitation-coupled mass spectrometry approach, we identified that ZIKV-NS5 interacted with p53 protein. The NS5-p53 interaction was further confirmed by co-immunoprecipitation and GST pull-down assays. In addition, the MTase domain of NS5 and the C-terminal domain of p53 were mapped to be responsible for the interaction between these two proteins. We further showed that ZIKV-NS5 was colocalized with p53 and increased its protein level in the nuclei and able to prolong the half-life of p53. Furthermore, lentivirus-mediated expression of ZIKV-NS5 in hNPCs led to an apparent cell death phenotype. ZIKV-NS5 promoted the cleavage of PARP1 and significantly increased the cell apoptosis of h NPCs.Taken together, these findings revealed that ZIKV-NS5 is a previously undiscovered regulator of p53-mediated apoptosis in hNPCs, which may contribute to the ZIKV-caused abnormal neurodevelopment. | Ping Li Hualian Jiang Hong Peng Weijie Zeng Yongheng Zhong Miao He Luyang Xie Junhai Chen Deyin Guo Junyu Wu Chun-Mei Li | 2021 | Virologica Sinica2021，36，6： | 2 |
| 5 | Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis:a review显示文摘Ulcerative colitis(UC)is a chronic systematic inflammation disorder with increasing incidence,unknown pathogenesis,limited drug treatment,and abundant medical expenses.Dietary intake,as a daily indispensable environment factor,is closely related to UC pathogenesis and prevention.The underlying interactions between dietary intake and UC progression are implicated with the modulation of gut microbiome as well as microbial metabolites,suggesting the complex and systematic characteristics of UC.However,the triangular relationships with dietary intake,gut microbiota homeostasis,and UC have not been well summarized so far.Here we review the recent studies of dietary intake on the regulation of gut microbiome homeostasis as well as modulation of UC progression.These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites,which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation,inftammation restriction as well as epithelial barrier maintenance,thus finally determine the fate of UC progression and give implications for functional food development for prevention and treatment of UC patients. | Wen Zeng Dong He Yifan Xing Junyu Liu Nan Su Chong Zhang Yi Wang Xinhui Xing | 2021 | Food Science and Human Wellness2021，10，2： | 2 |
| 6 | Charge vibration behaviour in polyimide under the pulse voltage with different rise and fall times显示文摘High‐voltage electronic equipment is widely used in power systems,which normally operate under the pulse voltage condition.However,compared to DC or AC stress,the electrical insulation suffers a more severe ageing process under a pulse voltage with steep edges and so may cause electrical equipments to fail early.The charge behaviour in polyimide under the pulse voltage with different edge times was investigated in this study.The experimental results show that charges vibrate at the pulse edge,while the amplitude of charge vibration increases with decreasing edge times.Furthermore,the detected vibration signal is strong within the nanosecond edge times,while being negligible in the microsecond range.Notably,the amplitude of charge vibration at the falling edge is larger than that at the rising edge in the presence of the column‐plate electrode.It is believed that the resultant force acting on the charge increases drasti-cally at the pulse edges,leading to the charge movement and the generation of ultra-sonic waves,with the resultant force becoming larger when the edge times decrease.Charge vibration behaviour is harmful to the microstructure of insulation materials,and so it may be concluded that the rise and fall times of the pulse voltage play an important role in insulation failure. | Tao Zhang Dongxin He Junyu Wei Hongshun Liu Qingquan Li Gilbert Teyssedre | 2022 | High Voltage2022，7，1： | 2 |
| 7 | Genotypic varia- tion in grain cadmium concentration of lowland rice显示文摘 | He Junyu Zhu Cheng Ren Yanfang | 2006 | Jour- nal of Plant Nutrition and Soil Science2006，169，5： | 1 |
| 8 | Genotypic variation in grain mercury accumulation of lowland rice显示文摘 | Zhu C Shen GM Yan YP He Junyu | 2008 | Journal of Plant Nutrition and Soil Science2008，171，2： | 1 |
| 9 | Protective roles of nitric oxide on seed germination and seedling growth of rice ( Oryza sativa L.) under cadmium stress显示文摘 | Junyu He Yanfang Ren Xiulan Chen Hui Chen | 2014 | Ecotoxicology and Environmental Safety2014，，： | 1 |
| 10 | Trends, temporaland spatial characteristics, and uncertainties in biomass burn-ing emissions in the Pearl River Delta?China显示文摘 | HE Min ZHENG Junyu YIN Shasha | 2011 | AtmosphericEnvironment2011，45，24： | 1 |
| 11 | Engineering organoid microfluidic system for biomedical and health engineering:A review显示文摘In recent years,organoid technology,i.e.,in vitro three-dimensional(3D)tissue culture,has attracted increasing attention in biomedical engineering.Organoids are cell complexes induced by differentiation of stem cells or organ-progenitor cells in vitro using 3D culture technology.They can replicate the key structural and functional characteristics of the target organs in vivo.With the opening up of this new field of health engineering,there is a need for engineering-system approaches to the production,control,and quantitative analysis of organoids and their microenvironment.Traditional organoid technology has limitations,including lack of physical and chemical microenvironment control,high heterogeneity,complex manual operation,imperfect nutritional supply system,and lack of feasible online analytical technology for the organoids.The introduction of microfluidic chip technology into organoids has overcome many of these limitations and greatly expanded the scope of applications.Engineering organoid microfluidic system has become an interdisciplinary field in biomedical and health engineering.In this review,we summarize the development and culture system of organoids,discuss how microfluidic technology has been used to solve the main technical challenges in organoid research and development,and point out new opportunities and prospects for applications of organoid microfluidic system in drug development and screening,food safety,precision medicine,and other biomedical and health engineering fields. | Yifan Xing Junyu Liu Xiaojie Guo Haipeng Liu Wen Zeng Yi Wang Chong Zhang Yuan Lu Dong He Shaohua Ma Yonghong He Xin-Hui Xing | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 1 |
| 12 | Migration of marrow stromal cells in response to sustained release of stromal-derived factor-1α from poly(lactide ethylene oxide fumarate) hydrogels显示文摘 | Xuezhong He Junyu Ma Esmaiel Jabbari | 2010 | International Journal of Pharmaceutics2010，，2： | 1 |
| 13 | Trends, temporal and spatial characteristics, and uncertainties in biomass burning emissions in the Pearl River Delta, China显示文摘 | Min He Junyu Zheng Shasha Yin Yingyi Zhang | 2011 | Atmospheric Environment2011，，24： | 1 |
| 14 | Root morphology and cadmium uptake kinetics of the cadmium-sensitive rice mutant显示文摘 | He Junyu Zhu Cheng Ren Yanfang | 2007 | Biologia Plantarum2007，51，4： | 1 |
| 15 | Accumulation of copper in brown rice and effect of copper on rice growth and grain yield in different rice cultivars显示文摘 | YuPing Yan JunYu He Cheng Zhu | 2006 | Chemosphere2006，65，： | 1 |
| 16 | Algal community structure prediction by machine learning显示文摘The algal community structure is vital for aquatic management.However,the complicated environmental and biological processes make modeling challenging.To cope with this difficulty,we investigated using random forests(RF)to predict phytoplankton community shifting based on multi-source environmental factors(including physicochemical,hydrological,and meteorological variables).The RF models robustly predicted the algal communities composed by 13 major classes(Bray-Curtis dissimilarity=9.2±7.0%,validation NRMSE mostly<10%),with accurate simulations to the total biomass(validation R^(2)>0.74)in Norway's largest lake,Lake Mjosa.The importance analysis showed that the hydro-meteorological variables(Standardized MSE and Node Purity mostly>0.5)were the most influential factors in regulating the phytoplankton.Furthermore,an in-depth ecological interpretation uncovered the interactive stress-response effect on the algal community learned by the RF models.The interpretation results disclosed that the environmental drivers(i.e.,temperature,lake inflow,and nutrients)can jointly pose strong influence on the algal community shifts.This study highlighted the power of machine learning in predicting complex algal community structures and provided insights into the model interpretability. | Muyuan Liu Yuzhou Huang Jing Hu Junyu He Xi Xiao | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 17 | Reshaping plasmon modes by film interference显示文摘Localized surface plasmon resonances(LSPRs)in metal nanostructures have been a central subject of nano-photonics due to their ability to manipulate light beyond the optical diffraction limit.Nevertheless,the large intrinsic dissipations of LSPRs have severely hindered their applications,so the on-demand control of the LSPR modes is highly desired and remains open yet.Here,we experimentally and theoretically demonstrate that the plasmon mode can be effectively engineered by interacting with constructive or destructive modes supported by film interference.When a metal nanoparticle interacts with a constructive mode,the dissipation linewidth of its LSPR mode shows a significant reduction of 58%.Simultaneously,the scattering intensity is remarkably enhanced,in vast favor of measuring weak signals from small nanoparticles.Furthermore,the film-destructiveinterference splitting in the scattering spectrum by weak coupling,rather than strong coupling,is revealed if the plasmon particles interact with the destructive mode,resulting in two new hybrid plasmon modes with narrow linewidths.The effective polarizability model of reshaping the LSPR modes by the film interference is present to well understand the experimental observations.Our work may pave the way toward low-loss plasmonic photonics and its practical applications. | Jin Liu Wei Li Junyu Li Jie Zhong He Feng Renming Liu Xue-Hua Wang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，11： | 0 |
| 18 | Behaviour and mechanisms of molecular vibrations induced by a pulsed voltage in a silicone elastomer used for device encapsulation显示文摘Silicone elastomers are widely used to encapsulate power electronic devices.However,such devices may be subjected to square‐wave pulsed voltages with a high rate of change,which can create significant challenges for encapsulation insulation.In this article,the molecular vibration of silicon elastomer at the edge of pulsed electric field is studied.Firstly,the relationship between the intensity of molecular vibration and the parameters of pulsed electric field is explored.The experimental results show that the amplitude of the vibrations decreases as the pulse‐edge time increases,and it increases linearly as the pulseedge slope increases.Furthermore,the amplitude of the vibrations is proportional to the square of the amplitude of the pulsed electric field,and it increases as the space charge density increases.Then,the force analysis of charged molecule at the pulse edges is calculated,and the theoretical change law of molecular vibration intensity with pulse edge slope is deduced.Comparing the theoretical results with the experimental results,it is found that they are highly consistent.Finally,electrically induced mechanical stress caused by molecular vibration was shown to be an important factor in insulation failure. | Junyu Wei Dongxin He Teng Gao Lin Zhu Haochen Wang Qingquan Li Gilbert Teyssedre | 2023 | High Voltage2023，8，5： | 0 |
| 19 | Combined QTL mapping,GWAS and transcriptomic analysis revealed a candidate gene associated with the timing of spring bud flush in tea plant(Camellia sinensis)显示文摘Dear Editor,The timing of the spring bud f lush(TBF)is a crucial agro-nomic trait for the tea plant,as it strongly influences the yield and economic value of harvested fresh tea leaves.The TBF of tea plant is generally defined as the date when>30%of the growing tender shoots have reached the stage of one bud with one to three leaves,referred as to the stage of one and a bud,two and a bud,and three and a bud,respectively. | Yujie Liu Si Chen Chenkai Jiang Haoran Liu Junyu Wang Weizhong He Doogyung Moon Jiedan Chen Liang Chen Jianqiang Ma | 2023 | Horticulture Research2023，10，9： | 0 |
| 20 | An Availability Evaluation Method of Web Services Using Improved Grey Correlation Analysis with Entropy Difference and Weight显示文摘Web services is one of the basic network services, whose availability evaluation is of great significance to the promotion of users’ experience. This paper focuses on the problem of availability evaluation of Web services and proposes a method for availability evaluation of Web services using improved grey correlation analysis with entropy difference and weight (EWGCA).This method is based on grey correlation analysis, and use entropy difference to illustrate the changes of availability, set weight to quantize availability requirements of different operations or transactions in services. Through simulation experiment in high load scenarios for Web services, the experiment result shows that our method can realize hierarchical description and overall evaluation for availability of Web services accurately in the case of smaller test sample volumes or uncertain data even in the field of big data. | Zhanbo He Huiqiang Wang Junyu Lin Guangsheng Feng Hongwu Lv Yibing Hu | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
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