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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Schisandrol B protects against acetaminophen- induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway显示文摘目的: 原子因素 erythroid 2-related 因素(NRF2 ) 2 通过抗氧化剂反应元素行动() 处理调整许多除去和为 cytoprotective 负责的抗氧化剂基因的表示。我们以前报导从五味子 sphenanthera 孤立的 Schisandrol B (SolB ) 对导致的 acetaminophen (APAP ) 生产了保护的效果肝损害。在这研究,我们调查了表明小径的 NRF2/ARE 是否涉及这 hepato 保护的 effect.Methods : 男 C57BL/6 老鼠与 SolB 被对待(200 mg· kg −1·d−1, ig ) 为在 APAP 的注射前的 3 d (400 mg/kg, ip ) 。浆液和肝织物样品被收集 6 h 以后。mRNA 和蛋白质表示分别地用 qRT-PCR 和西方的污点试金被测量。 NRF2 的激活用酶记者基因 assay.Results 在 HepG2 房间被检验:显著地减轻的 SolB 预告的处理肝的损害(肝的湾穴的大补缀的坏死和 hyperemia ),浆液著名计算机生产厂商的增加,中高音层次和肝的 MDA 满足,并且肝和 mitochondrial 谷胱甘肽的减少在 对待APAP 的老鼠铺平。而且, SolB 预告的处理显著地增加了 NRF2 的原子累积并且增加了 NRF2 下游的蛋白质的肝的表示,包括在对待 APAP 的鼠标的 GCLC, GSR, NQO1, GST, MRP2, MRP3 和 MRP4。而且,有 SolB 的处理(2.5-20 μ mol/L ) dose-dependently 在 HepG2 cells.Conclusion 增加了 NRF2 记者基因的活动: SolB 对导致 APAP 的 hepatotoxicity 展出显著保护的效果,部分,经由 NRF2/ARE 的激活, NRF2 的小径和规定指向基因,它导致 detoxification 和增加抗氧化剂能力。 | Yi-ming JIANG Ying WANG Hua-sen TAN Tao YU Xiao-mei FAN Pan CHEN Hang ZENG Min HUANG Hui-chang BI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 24 |
| 3 | Three-dimensional morphometric analysis for hepatectomy of centrally located hepatocellular carcinoma:A pilot study显示文摘AIM: To describe a three-dimensional model(3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas(HCCs).METHODS: From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed tomography(CT) model with customdeveloped software. CT images were used for the 3D reconstruction of Couinaud's pedicles and hepatic veins, and the calculation of corresponding tumor territories and hepatic segments was performed using Yorktal DMIT software. The respective volume, surgical margin, and simulated virtual resection of tumors were also estimated by this model preoperatively. All patients were treated surgically and the results were retrospectively assessed. Clinical characteristics, imaging data, procedure variables, pathologic features, and postoperative data were recorded and compared to determine the reliability of the model.RESULTS: 3D reconstruction allowed stereoscopic identification of the spatial relationships between physiologic and pathologic structures, and offered quantifiable liver resection proposals based on individualized liver anatomy. The predicted values were consistent with the actual values for tumor mass volume(82.4 ± 109.1 m L vs 84.1 ± 108.9 m L, P = 0.910), surgical margin(10.1 ± 6.2 mm vs 9.1 ± 5.9 mm, P = 0.488), and maximum tumor diameter(4.61 ± 2.16 cm vs 4.53 ± 2.14 cm, P = 0.871). In addition,the number and extent of portal venous ramifications, as well as their relation to hepatic veins, were visualized. Preoperative planning based on simulated resection facilitated complete resection of large tumors located in the confluence of major vessels. And most of the predicted data were correlated with intraoperative findings.CONCLUSION: This 3DM provides quantitative morphometry of tumor masses and a stereo-relationship with adjacent structures, thus providing a promising technique for the management of centrally located HCCs. | Fei Tian Jian-Xiong Wu Wei-Qi Rong Li-Ming Wang Fan Wu Wei-Bo Yu Song-Lin An Fa-Qiang Liu Li Feng Chao Bi Yun-He Liu | 2015 | World Journal of Gastroenterology2015，21，15： | 21 |
| 4 | Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology显示文摘INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabilizing the phenotype of cell.DNA methylation status reduction and/or patternalteration are related to activation and abnormallyhigh expression of some oncogenes and cellularmalignancy[1-6]. c-fms oncogene encodes for colonystimulating factor 1 receptor (CSF-1R)[7], c-fms/CSF-1R was highly expressed in hepatocellularcarcinoma (HCC) tissue, but the mechanismremained obscure[8,9]. | Jun Cui Dong Hua Yang Xiang Jun Bi Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 16 |
| 5 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 6 | Genetic differentiation of Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) biotype Q based on mitochondrial DNA markers显示文摘在现在的学习, Bemisia tabaci (Gennadius ) 的基因区别遗传因子型 Q 基于 mitochondrial 细胞色素氧化酶被分析我(mt COI ) 基因顺序。结果显示出那 B。tabaci 遗传因子型 Q 能被分开成二 subclades,它作为 subclades Q1 和 Q2 被标记。Subclade Q1 对在地中海区域和 subclade Q2 附近的区域可能土生土长到以色列或赛浦路斯。它是因为 B。tabaci 与在更密切相关的遗传因子型之间的一个强壮的地理协会由几个遗传上不同的组组成。并非所有 B。在非地中海国家的 tabaci 遗传因子型 Q 来自一样的区域。直到现在,所有 B。在中国的 tabaci 遗传因子型 Q 被组织进 subclade Q1。B。介绍进 US 的 tabaci 遗传因子型 Q 包括了 subclades Q1 和 Q2。基因结构分析比 subclade Q2 的显示出 subclade Q1 的更高的遗传变异。 | Dong Chu Fang-Hao Wan Yun-Li Tao Guo-Xia Liu Zhong-Xue Fan Yu-Ping Bi | 2008 | Insect Science2008，15，2： | 12 |
| 7 | Evaluation of the simulation capability of the Wavewatch Ⅲ model for Pacific Ocean wave显示文摘Wave climate analysis and other applications for the Pacific Ocean require a reliable wave hindcast. Five source and sink term packages in the Wavewatch III model(v3.14 and v4.18) are compared and assessed in this study through comprehensive observations, including altimeter significant wave height, advanced synthetic aperture radar swell, and buoy wave parameters and spectrum. In addition to the evaluation of typically used integral parameters, the spectra partitioning method contributes to the detailed wave system and wave maturity validation. The modified performance evaluation method(PS) effectively reduces attribute numbers and facilitates the overall assessment. To avoid possible misleading results in the root mean square error-based validations, another indicator called HH(indicating the two authors) is also calculated to guarantee the consistency of the results. The widely used Tolman and Chalikov(TC) package is still generally efficient in determining the integral properties of wave spectra but is physically deficient in explaining the dissipation processes. The ST4 package performs well in overall wave parameters and significantly improves the accuracy of wave systems in the open ocean. Meanwhile, the newly published ST6 package is slightly better in determining swell energy variations. The two packages(ACC350 and BJA) obtained from Wavewatch III v3.14 exhibit large scatters at different sea states. The three most ideal packages are further examined in terms of reproducing waveinduced momentum flux from the perspective of transport. Stokes transport analysis indicates that ST4 is the closest to the NDBC-buoy-spectrum-based transport values, and TC and ST6 tend to overestimate and underestimate the transport magnitude, respectively, in swell mixed areas. This difference must be considered,particularly in air–wave–current coupling research and upper ocean analysis. The assessment results provide guidance for the selection of ST4 for use in a background Pacific Ocean hindcast for high wave climate research and China Sea swell type analysis. | BI Fan SONG Jinbao WU Kejian XU Yao | 2015 | Acta Oceanologica Sinica2015，34，9： | 10 |
| 8 | Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis显示文摘AIM: To evaluate the effect of artesunate(AS) supplementation on bacterial translocation(BT) and gut microbiota in a rat model of liver cirrhosis. METHODS: Fifty-four male Sprague-Dawley rats were randomly divided into a normal control group(N), a liver cirrhosis group(M) and a liver cirrhosis group intervened with AS(MA). Each group was sampled at 4, 6 and 8 wk. Liver cirrhosis was induced by injection of carbon tetrachloride(CCl4), intragastric administration of 10% ethanol, and feeding a high fat diet. Rats in the MA group were intragastrically administered with AS(25 mg/kg body weight, once daily). Injuries of the liver and intestinal mucosa were assessed by hematoxylineosin or Masson's trichrome staining. Liver index was calculated as a ratio of the organ weight(g) to body weight(g). The gut microbiota was examined by automated ribosomal intergenic-spacer analysis of fecal DNA. BT was assessed by standard microbiological techniques in the blood, mesenteric lymph nodes(MLNs), liver, spleen, and kidney. RESULTS: Compared to group N, the body weight was reduced significantly in groups M and MA due to the development of liver cirrhosis over the period of 8 wk. The body weight was higher in group MA than in group M. The liver indices were significantly elevated at 4, 6 and 8 wk in groups M and MA compared to group N. AS supplementation partially decreased the liver indices in group MA. Marked histopathologic changes in the liver and small intestinal mucosa in group M were observed, which were alleviated in group MA. Levels of pro-inflammatory interleukin-6 and tumor necrosis factor-α were significantly elevated at 8 wk in ileal homogenates in group M compared to group N, which were decreased after AS supplementation in group MA. The dysbiosis of gut microbiota indicated by the mean diversity(Shannon index) and mean similarity(Sorenson index) was severe as the liver cirrhosis developed, and AS supplementation had an apparent intervention effect on the dysbiosis of gut microbiota at 4 wk. The occurrence of BT was increased in the liver of group M compared to that of group N. AS supplementation reduced BT in group MA at 8 wk. BT also occurred in the MLNs, spleen, and kidney, which was reduced by AS supplementation. BT was not detected in the blood in any group.CONCLUSION: Dysbiosis of gut microbiota, injury of intestinal mucosal barrier and BT occurred as liver cirrhosis progressed, which might enhance inflammation and aggravate liver injury. AS may have other nonantimalarial effects that modulate gut microbiota,inhibit BT and alleviate inflammation, resulting in a reduction in CCl4, alcohol and high fat-caused damages to the liver and intestine. | Yun-Xia Chen Li-Na Lai Hui-Ying Zhang Yang-Hui Bi Li Meng Xu-Jiong Li Xiao-Xia Tian Li-Min Wang Yi-Min Fan Zhong-Fu Zhao De-Wu Han Cheng Ji | 2016 | World Journal of Gastroenterology2016，22，10： | 10 |
| 9 | Differential expression of microRNAs in aortic tissue and plasma in patients with acute aortic dissection显示文摘尖锐大动脉的解剖(AAD ) 的帮助 BackgroundBiomarker 的诊断为诊断和治疗是重要的。然而,为在血的 AAD 的 biomarkers 的鉴定是挑战性的任务 . 这研究的目的是寻找新潜在地,在 AAD.MethodsThe miRNAs 表示的 microRNA (miRNAs ) biomarkers 在登上大动脉的织物和血浆介绍被 microarray 分析在二个集合或组检验。织物组与 AAD 和健康男机关施主的四控制由四个病人组成。没有心血管的疾病,血浆组与 AAD 和 20 控制包括了 20 个病人。生物信息学被用来分析 miRNAs.ResultsOur 学习揭示了的表示的差别的潜在的目标在 AAD 病人,大动脉的织物有 30 差别,这表示了 miRNAs 与 13 起来调整并且 17 下面调整,并且血浆 93 差别表示了 miRNAs, 33 是起来调整的, 60 是下面调整的。四 miRNAs 被发现在 AAD 病人在大动脉的织物和血浆起来调整。预言的 miRNA 目标显示四 dysregulated miRNAs 主要指向了与房间房间粘附,细胞外的矩阵新陈代谢,细胞骨架组织,发炎,和与细胞的 cycles.ConclusionsFour miRNAs 有关的多重发信号小径被联系的基因,它在大动脉的织物并且在在 AAD 病人的血浆是起来调整的,在这研究被识别了。这些 miRNAs 可能是为 AAD 的潜在的诊断 biomarkers。更大的样品调查为进一步的确认被需要。 | Xiao-Jian WANG Bi HUANG Yan-Min YANG Liang ZHANG Wen-Jun SU Li TIAN Tian-Yi LU Shu ZHANG Xiao-Han FAN Ru-Tai HUI | 2015 | Journal of Geriatric Cardiology2015，12，6： | 9 |
| 10 | The effect of Stokes drift on Ekman transport in the open sea显示文摘By introducing the wave-induced Coriolis-Stokes forcing into ageostrophic motion equation,the Eulerian transport is modified by the wave-induced Stokes drift.The long-term mean contributions of the Stokes transport with remotely generated swells being included to the ageostrophic transport are analyzed using the ECMWF(European Centre for Medium-Range Weather Forecasts) reanalysis data.The ratio of Stokes transport to Ekman transport in north-south(N-S) direction can reach a maximum of over 50% in the subtropical region.The preliminary influence of the Stokes transport on the North Pacific gyre is all year persistent,while the effect on the North Atlantic gyre is only obvious in boreal winter and early spring. | BI Fan WU Kejian ZHANG Yuming | 2012 | Acta Oceanologica Sinica2012，31，6： | 8 |
| 11 | 磁共振单次扫描多组织对比序列对颈动脉粥样硬化斑块评价的临床初步研究显示文摘目的评价MR 3D单次扫描多组织对比序列(MATCH)定量评价颈动脉血管形态学和定性评价斑块内成分的价值。方法选择超声检查发现颈动脉狭窄>50%且拟行颈动脉内膜剥脱术患者30例,术前分别行MATCH(5min)及MRI常规多序列扫描(T1WI,T2WI,三维时间飞跃和质子密度加权像,18min),扫描范围以颈动脉分叉为中心覆盖全部斑块。用MRI-Plaque View软件分析斑块形态学参数:管腔面积(LA)、管壁面积(WA)、标准化管壁指数(NWI),定性评价斑块内成分,包括斑块内出血(IPH)、斑块钙化(CA)、斑块脂质核心(LRNC)。用Cohen kappa分析2种序列对斑块内成分定性的一致性。结果 30例患者双侧颈动脉入选898个图像层面,MATCH和常规序列LA[(36.27±24.23)mm2 vs(35.72±20.12)mm2,t=1.87,P=0.062],WA[(42.80±20.67)mm2 vs(43.64±24.87)mm2,t=1.74,P=0.082],NWI[(59.21±13.90)vs(59.81±13.96),t=1.80,P=0.072]无显著差异。MATCH与常规序列判断斑块内成分有中到高度的一致性(LRNC:κ值=0.840,CA:κ值=0.802,IPH:κ值=0.773)。结论 MATCH有可能成为评估颈动脉易损斑块成分及斑块破裂危险程度的新方法。 | 杨利新 于薇 Fan ZY Xie YB 王占宏 Bi XM 安靖 张天静 Li DB | 2015 | 中华老年心脑血管病杂志2015，17，11： | 8 |
| 12 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 13 | Influence of Puncture Site on Radial Artery Occlusion After Transradial Coronary Intervention显示文摘 | Xi-Le Bi Xiang-Hua Fu Xin-Shun Gu Yan-Bo Wang Wei Li Li-Ye Wei Yan-Ming Fan Shi-Ru Bai | 2016 | Chinese Medical Journal2016，，8： | 7 |
| 14 | OpenKG Chain:A Blockchain Infrastructure for Open Knowledge Graphs显示文摘The early concept of knowledge graph originates from the idea of the semantic Web,which aims at using structured graphs to model the knowledge of the world and record the relationships that exist between things.Currently publishing knowledge bases as open data on the Web has gained significant attention.In China,Chinese Information Processing Society of China(CIPS)launched the OpenKG in 2015 to foster the development of Chinese Open Knowledge Graphs.Unlike existing open knowledge-based programs,OpenKG chain is envisioned as a blockchain-based open knowledge infrastructure.This article introduces the first attempt at the implementation of sharing knowledge graphs on OpenKG chain,a blockchain-based trust network.We have completed the test of the underlying blockchain platform,and the on-chain test of OpenKG’s data set and tool set sharing as well as fine-grained knowledge crowdsourcing at the triple level.We have also proposed novel definitions:K-Point and OpenKG Token,which can be considered to be a measurement of knowledge value and user value.1,033 knowledge contributors have been involved in two months of testing on the blockchain,and the cumulative number of on-chain recordings triggered by real knowledge consumers has reached 550,000 with an average daily peak value of more than 10,000.For the first time,we have tested and realized on-chain sharing of knowledge at entity/triple granularity level.At present,all operations on the data sets and tool sets at OpenKG.CN,as well as the triplets at OpenBase,are recorded on the chain,and corresponding value will also be generated and assigned in a trusted mode.Via this effort,OpenKG chain looks forward to providing a more credible and traceable knowledge-sharing platform for the knowledge graph community. | Huajun Chen Ning Hu Guilin Qi Haofen Wang Zhen Bi Jie Li Fan Yang | 2021 | Data Intelligence2021，3，2： | 7 |
| 15 | Climate and extrema of ocean waves in the East China Sea显示文摘Wave climate plays an important role in the air-sea interaction over marginal seas. Extreme wave height provides fundamental information for various ocean engineering practices, such as hazard mitigation, coastal structure design, and risk assessment. In this paper, we implement a third generation wave model and conduct a high-resolution wave hindcast over the East China Sea to reconstruct a 15-year wave field from 1988 to 2002 for derivation of monthly mean wave parameters and analysis of extreme wave conditions. The numerical results of the wave field are validated through comparison with satellite altimetry measurements, low-resolution reanalysis, and the ocean wave buoy record. The monthly averaged wave height and wave period show seasonal variation and refined spatial patterns of surface waves in the East China Sea. The climatological significant wave height and mean wave period decrease from the open ocean in the southeast toward the continental area in the northwest, with the pattern generally following the bathymetry. Extreme analysis on the significant wave height at the buoy station indicates the hindcast data underestimate the extreme values relative to the observations. The spatial pattern of extreme wave height shows single peak emerges at the southwest of Ryukyu Island although a wind forcing with multi-core structure at the extreme is applied. | Hailun HE Jinbao SONG Yefei BAI Yao XU Juanjuan WANG Fan BI | 2018 | Science China Earth Sciences2018，61，7： | 7 |
| 16 | Good Manufacturing Practices production and analysis of a DNA vaccine against dental caries显示文摘 | Ya-ping YANG Yu-hong LI Ai-hua ZHANG Lan BI Ming-wen FAN | 2009 | Acta Pharmacologica Sinica2009，30，11： | 6 |
| 17 | Development of the fingerprints for the quality evaluation of Viscum coloratum by high performance liquid chromatography显示文摘A high-performance liquid chromatography coupled ultraviolet(HPLC-UV)method was developed for a chemical fingerprint analysis of Viscum coloratum.Eighteen peaks were selected as the common peaks and Homoeriodictyol-7-O-β-D-apiosiyl-(1→2)-β-D-glucoside was used as a reference.The relative areas of common peaks were used for hierarchical clustering analysis and similarity calculation.Thirty-seven samples collected from different sources were classified into five groups.The similarities of 21 batches Viscum coloratum samples were beyond 0.90.The results obtained suggest that the chromatographic fingerprint can efficiently identify Viscum coloratum.Additionally,the fingerprints can then be used to evaluate the correlation between Viscum coloratum and hosts. | Yun-Li Zhao Rong-Hua Fan Hong-Xia Yuan Miao Yu Kai-Shun Bi Zhi-Guo Yu | 2011 | Journal of Pharmaceutical Analysis2011，1，2： | 6 |
| 18 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 19 | NSHV trajectory prediction algorithm based on aerodynamic acceleration EMD decomposition显示文摘Aiming at the problem of gliding near space hypersonic vehicle(NSHV)trajectory prediction,a trajectory prediction method based on aerodynamic acceleration empirical mode decomposition(EMD)is proposed.The method analyzes the motion characteristics of the skipping gliding NSHV and verifies that the aerodynamic acceleration of the target has a relatively stable rule.On this basis,EMD is used to extract the trend of aerodynamic acceleration into multiple sub-items,and aggregate sub-items with similar attributes.Then,a prior basis function is set according to the aerodynamic acceleration stability rule,and the aggregated data are fitted by the basis function to predict its future state.After that,the prediction data of the aerodynamic acceleration are used to drive the system to predict the target trajectory.Finally,experiments verify the effectiveness of the method.In addition,the distribution of prediction errors in space is discussed,and the reasons are analyzed. | LI Fan XIONG Jiajun LAN Xuhui BI Hongkui CHEN Xin | 2021 | Journal of Systems Engineering and Electronics2021，32，1： | 6 |
| 20 | Inadequate glycaemic control and antidiabetic therapy among inpatients with type 2 diabetes in Guangdong Province of China显示文摘背景糖尿病 mellitus 在调查的 China.We 在最近的年里变得流行在来自在广东省教医院的十所大学的类型 2 糖尿病的住院病人之中的多糖症和不适当的 glycaemic 控制的流行,中国。当 HbA1c() 6.5%.Therapeutic 政体包括了没有干预,在糖尿病的病人的方法不适当的 glycaemic 控制被定义,生活方式仅仅,口头的 antiglycemic 代理人(OA ) ,加 OA (insulin+OA ) 的胰岛素,或胰岛素仅仅。Antidiabetic 管理包括了 monotherapy,两倍治疗,三元组或四倍的治疗。在有已知的历史的 493 个糖尿病的住院病人之中的结果, 75%had HbA1c6.5%.Inadequate 葡萄糖控制率更经常比在 OA 政体(71%)( PO.001 )上在 insulin+OA 政体(97%)上在病人被看见,并且在联合治疗(81%-96%)上的病人更经常比 monotherapy (75%)( P0.05 ),胰岛素上的 .Patients 由吝啬的 HbA1c , glycemic 控制率,糖尿病持续时间, microvascular 复杂并发症,和 BMI ( P0.01 )在 OA 上与病人显著地不同。这研究看了类型 2 糖尿病的病人的那 glycaemic 控制的结论为胰岛素的收到的胰岛素和开始时间通常是谁的病人败坏了 delayed.It 依赖临床医生从传统的逐步的治疗搬到更活跃、早的联合 antidiabetic 治疗提供更好的葡萄糖控制。 | BI Yan YAN Jin-hua LIAO Zhi-hong LI Yan-bing ZENG Long-yi TANG Kuan-xiao XUE Yao-ming YANG Hua-zhang LI Lu CAI De-hong WU Ge ZHANG Fan LIN Shao-da XIAO Zheng-hua ZHU Da-long WENG Jian-ping | 2008 | Chinese Medical Journal2008，，8： | 5 |
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