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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | Distribution of Antibiotic MICs for Helicobacter pylori Strains over a 16-Year Period in Pa tients from Seoul, South Korea 显示文摘 | Kim JM Kim Js Jun HC | 2004 | Antimicrob Agents Chemother2004，48，12： | 1 |
| 3 | Estrogenic and Ant-iestrogenic acitivities of phloridzin显示文摘 | Jun ZW Mi HC BingJie X | | 0，，4： | 1 |
| 4 | Optimized solid-state synthesis of LiFePO4 cathode materials using ball-milling显示文摘 | KANG HC JUN D K JIN B et ai | 2008 | J Power Sources2008，179，1： | 1 |
| 5 | Endoscopic thyroidectomy using a new bilateral axillo breast approach显示文摘 | Jun HC Seok WK Ki WC | | 0，，03： | 1 |
| 6 | An Anatomic Study of the Superficial Peroneal Nerve Accessory Artery Perforator Flaps显示文摘 | Jun SK Dae GS Tac HC | 2008 | Annals of Plastic Surgery2008，5，6： | 1 |
| 7 | Endoscopic ultrasonography - guided ethanol lavage withpaclitaxel injection treats patients with pancreatic cysts 显示文摘 | Oh HC SEO Dong - wan SONG Tae - jun | 2011 | Gastroenterology2011，140，1： | 1 |
| 8 | Association of interleukila-10 promoter region polymorphisms with risk factors of Atherosclerosis 显示文摘 | Yu GI Jun SE Cho HC | 2015 | Int J Immunogenet2015，42，1： | 1 |
| 9 | The Use of Adjusted Preoperative CA 19-9 to Predict the Recurrence of Resectable Pancreatic Cancer显示文摘 | Chang MK Jun YK Gi HC | 2007 | J Surg Res2007，140，1： | 1 |
| 10 | The impact of Seoul' s subway Line 5 on residential property values 显示文摘 | Bae C - HC Jun M - J Park H | 2003 | Transport Policy2003，10，2： | 1 |
| 11 | An anatomic study of the superficial peroneal nerve accessory artery perforator flaps显示文摘 | Jun SK Dae GS Tac HC | 2008 | Annals of Plastic Surgery2008，5，6： | 1 |
| 12 | Effects ofmyricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role ofcytochrome P450 3A4,cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin 显示文摘 | I Dong HC Cheng L Jun SC | 2010 | Journal of Pharmacy and Pharmacology2010，62，： | 1 |
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