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| 1 | 2022年WHO甲状腺肿瘤分类概述显示文摘2022年WHO第5版甲状腺肿瘤分类按细胞起源、病理特征、分子分型及生物学行为,分为良性、低危组和恶性。新分类变化不少,作者做了综述。将发育异常甲状舌管纳入;为避免结节性甲状腺肿定义为增生性、肿瘤性或矛盾的“腺瘤样增生”,编委会达成共识,命名为甲状腺滤泡结节性病变(FND)。基于分子谱和侵袭性,多种形态亚型的甲状腺乳头状癌(PTC)代表了BRAF样癌(浸润性生长、核非典型明显);而包裹型浸润性乳头状癌滤泡变异型/[IEFVPC,分子检测证实与滤泡性甲状腺癌(FTC)关系密切,不再归于PTC]与FTC代表RAS样癌(膨胀性生长、核非典型轻度)。 | Baloch ZW Asa SL Barletta JA 方三高(译) 魏建国(校) | 2022 | 诊断病理学杂志2022，29，12： | 63 |
| 2 | Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis显示文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF. | Xia Q Jiang JM Gong X Chen GY Li L Huang ZW | 2000 | World Journal of Gastroenterology2000，6，1： | 31 |
| 3 | Molecular mechanisms of H.pylori associated gastric carcinogenesis显示文摘 | Zhang ZW Farthing MJ | 1999 | World Journal of Gastroenterology1999，5，5： | 29 |
| 4 | Intra-habitat heterogeneity of microbial food web structure under the regime of eutrophication and sediment resuspension in the large subtropical shallow Lake Taihu, China显示文摘 | Wu QLL Chen YW Xu KD Liu ZW Hahn MW | 2007 | 中国生物学文摘2007，21，8： | 26 |
| 5 | 前瞻随机对照比较射频消融联合/不联合经导管肝动脉栓塞化疗术治疗肝细胞癌的临床研究显示文摘背景和目的射频消融术(RFA)是近年发展比较快的肝癌治疗手段,具有微创、操作简单、可反复治疗的特点,多项研究证明其对于小肝癌的疗效与手术切除相似,被认为是不能手术小肝癌的主要替代手段,甚至可作为小肝癌的一线治疗手段。经导管肝动脉栓塞化疗术(TACE)是中晚期肝癌的主要治疗手段。TACE联合射频消融,TACE可发现和治疗一些以前没有发现的微小病灶,控制肝肿瘤周围可能存在的微卫星灶,并有利于日后射频治疗的施行;此外,射频消融术前行TACE治疗,可以减少肝肿瘤的血流,从而减少射频消融过程中的热流失,从而增加消融范围;射频消融过程中产生的热量可以协同发挥TACE过程中注入化疗药物的疗效。因此TACE联合射频消融可提高肝细胞癌的疗效。本研究是第一项研究RFA联合TACE的前瞻随机对照研究,目的在于比较RFA联合或不联合TACE治疗肝细胞癌(HCC)的效果。方法此项单中心随机对照临床试验在中山大学肿瘤医院完成。自2006年10月至2009年6月,189例直径小于7 cm的肝细胞癌患者符合入选标准完成对照试验。入选标准:1年龄18~75岁;2HCC单个病灶≤7 cm,或3个或以下病灶,每个≤3 cm;3无影像学证据显示大血管侵犯且无肝外转移;4B超下可见病灶且病灶和腹壁之间有安全距离;5ECOG体力状态评分0;6之前未接受过HCC治疗;7患者Child-Pugh肝功能A或B级。患者随机接受TACE联合RFA治疗(TACE-RFA,n=94)或单纯RFA治疗(n=95)。该研究的主要终点为总体生存率,次要终点为无复发生存率,第三终点为不良事件。结果随访7至62月期间,TACE-RFA组死亡34例,复发33例;RFA组死亡48例,复发52例。TACE-RFA组与RFA组患者1年、3年及4年总体生存率分别为92.6%、66.6%、61.8%以及85.3%、59%和45.0%。两组对应的无复发生存率分别为79.4%、60.6%、54.8%以及66.7%、44.2%和38.9%。TACE-RFA组患者的总体生存率(RR=0.525,95%CI:0.335~0.822;P=0.002)以及无复发生存率(RR=0.575,95%CI:0.374~0.897;P=0.009)均优于RFA组患者。研究中未出现治疗相关死亡病例。Logistic回归分析显示,治疗分组、肿瘤大小以及肿瘤数量为患者总体生存率的显著预后因素,同时,治疗分组与肿瘤数量为患者无复发生存率的显著预后因素。结论对于直径小于7 cm的HCC患者,接受TACERFA较单纯RFA治疗生存获益更显著。 | Peng ZW Zhang YJ Chen MS 张信华 | 2013 | 消化肿瘤杂志(电子版)2013，5，3： | 23 |
| 6 | A New Caffeoyl Conjugate from Erigeron Breviscapus显示文摘Erigoster A (1a), a new compound with a novel basic skeleton, was isolated from Erigeron breviscapus. The structure elucidation and complete proton and carbon NMR assignments were achieved by the utilization of a combination of two- dimensional NMR | Yue, JM Lin, ZW Sun, HD | 1997 | Chinese Chemical Letters1997，8，3： | 20 |
| 7 | Impacts of ozone on the biomass and yield of rice in open top chambers显示文摘The impacts of different O 3 concentration on the biomass and yield of rice were studied by using OTC 1 open top chambers. Experimental treatments included the activated charcoal filtered air (CFA), 50 nl/L (CF50), 100 nl/L (CF100) and 200 nl/L (CF200) concentrations of O 3. The O 3 treatments significantly decreased the total biomass per plant. The elevated O 3 exposure resulted in a more decrease in the root growth than in the shoot growth. Assessments of yield characteristics at the final harvest revealed an O 3 induced decrease in the number of grains per plant, resulting from fewer ears per plant, fewer grains per ear and more unfilled grains per ear. The 1000 grain dry weight and the harvest index (HI) were not changed significantly under 50 nl/L or 100 nl/L O 3 exposure, but reduced by 17.0% and 4.8% by 200nl/L O 3 treatment, respectively. Compared to the CFA treatment, CF50, CF100 and CF200 treatments caused a 8.2%, 26.1%, 49.1% decrease of the grain yield per plant, and a 14 2%, 31 7%, 51 7% decrease of the total biomass per plant, respectively. Linear regression showed that the 7h-daily mean O 3 concentration exposure for 3 months (July September) and AOT40 (cumulative exposure accumulation over threshold 40 nl/L) were well correlated with the relative grain yield. A yield loss of 10% was estimated to be at 46 9 nl/L O 3 for 7h daily mean O 3 concentration exposure or at 12930 nl/(L·h) O 3 for AOT40. | Jin, MB Feng, ZW Zhang, FZ | 2001 | Journal of Environmental Sciences2001，13，2： | 16 |
| 8 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 9 | Eudesmanes and Eudesmanoic Glucosides from Laggera pterodonta显示文摘EudesmanesandEudesmanoicGlucosidesfromLaggerapterodonta￥YuZHAO;JianMinYue;JingKaiDING;ZhongWenLinandHanDongSUN(Laboratoryofph... | Zhao, Y Yue, JM Ding, JK Lin, ZW Sun, HD | 1996 | Chinese Chemical Letters1996，7，12： | 7 |
| 10 | 手机更智能——重力感应和电子罗盘技术显示文摘借助重力感应技术,在手机上旋转屏幕时,不用再去手动调节屏幕方向,而是让手机智能适应玩家使用需求,方便又快捷,在玩游戏时也不用再在小屏幕上点击方向,将手机左右倾斜就能达到控制方向的效果,操作更直观简便。而电子罗盘则显得更“神奇”,手机摇身一变成为指南针……现在重力感应和电子罗盘这两种技术在智能手机上可以说是广泛应用,那么它们的工作原理是怎样的呢? | ZW | 2011 | 电脑迷2011，，21： | 4 |
| 11 | Four New Compounds from Isodon Eriocalyx显示文摘Four new diterpenoids named maoecrystal Q-T (1-4) were isolated from the dried leaves of Isodon eriocalyx. Their sturctures were established by spectroscopic methods. | Wang, J Lin, ZW Shingu, T Sun, HD | 1997 | Chinese Chemical Letters1997，8，7： | 4 |
| 12 | A New Glucoside from Ceratostigma willmottianum显示文摘Ceratoside A (1), a new compound was isolated from the butanol-soluble fraction of Ceratostigma willmottianum , Its structure was determined by the utilizaion of 2D-NMR | Yue, JM Zhao, Y Xu, J Lin, ZW Sun, HD | 1997 | Chinese Chemical Letters1997，8，10： | 3 |
| 13 | Primary malignant tumor of the small intestine显示文摘 | Zhou ZW Wan DS Chen G Chen YB Pan ZZ | 1999 | World Journal of Gastroenterology1999，5，3： | 3 |
| 14 | 药物开发中与草药相互作用药物的鉴定显示文摘迄今为止,几种临床上重要的药物已被鉴定与常用的草药相互作用。这些药物包括华法林、咪达唑仑、地高辛、阿米替林、茚地那韦、环孢素A、他克莫司、伊立替康。重要的是这些药物大多治疗指数极窄,大部分是细胞色素P450(CYP)和(或)P糖-蛋白(P-gp)的底物。由于药物-草药相互作用能显著地影响药物的循环浓度,改变临床结果,因此与常用的草药相互作用的药物的鉴定在药物开发中具重要的意义。计算机模拟、体外、动物和人体研究经常用于鉴定药物和草药的相互作用。建议将药物-草药和草药-CYP相互作用研究纳入药物开发中。 | Zhou SF Zhou ZW Li CG 贾秀虹 | 2008 | 国际药学研究杂志2008，35，3： | 2 |
| 15 | Experimental observation on ferrous l-threonate improvement on nutritional iron deficiency anemia显示文摘 | YU K WANG ZW KOU FP | 1998 | Chin Child Blood (in Chinese)1998，3，1： | 2 |
| 16 | Eucaglobulin, A New Complex of Gallotannin and Monoterpene from Eucalyptus globulus显示文摘Eucaglobulin 1, a new complex of gallotannin and monoterpene, was isolated from theleaves of Eucalyptus globulus. Its structure was determined by spectral methods. | Hou, AJ Liu, YZ Lin, ZW Sun, HD | 1998 | Chinese Chemical Letters1998，9，6： | 2 |
| 17 | Evaluation of various solutions for small bowel graft preservation显示文摘EvaluationofvarioussolutionsforsmalbowelgraftpreservationLIYouSheng1,LIJieShou1,LINing1,JIANGZhiWei1,ZHAOYunZhao1,LINan?.. | Li YS Li JS Li N Jiang ZW Zhao YZ Li NY Liu FN | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 18 | Morphological characteristics of ZnO crystallites under hydrothermal conditions显示文摘THE ZnO powder (micro-crystallites), an important functional material, has a wide applica-tion in the fields of ceramics, coatings and electronic devices. However, the powder, usuallyobtained by calcination of zinc oxalate, has a wide particle-size distribution and poor sinteringactivities so various methods for its preparation have been developed. The hydrothermalmethod is widely used to prepare many superfine powders such as ZrO2, BaTiO3, PLZT, dueto many advantages compared with other methods. Recently, the powder of Ⅱ—Ⅵ com-pounds can also be prepared by this method. Furthermore, crystallite shapes may be consid- | Wang, BG Shi, EW Zhong, WZ Yin, ZW | 1997 | Chinese Science Bulletin1997，42，12： | 2 |
| 19 | A new caffeoyl conjugate from Erigeron breviscapus 显示文摘 | Yue JM Lin ZW Sun HD | 1977 | Chin Chem Lett1977，8，3： | 2 |
| 20 | Proceedings of the WHO, UNICEF,and SCN informal consultation on community-based management of severe malnutrition in children显示文摘 | Pruhon C Prinzo ZW Briend A | 2006 | Food Nutr Bull2006，27，3： | 1 |
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