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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 3 | Region-specific phosphorylation of ERK5-MEF2C in the rat frontal cortex and hippocampus after electroconvulsive shock显示文摘 | Yoon SC Ahn YM Jun SJ | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，5： | 1 |
| 4 | Single-balloon kyphoplasty in osteo- porotic vertebral compression fractures:far-lateral extrapedicular ap- proach 显示文摘 | Ryu KS Huh HY Jun SC | 2009 | J Korean Neurosurg Soc2009，45，： | 1 |
| 5 | Limitations to the development of humanized antibody producing Chinese hamster ovary cells using glutamine synthetase-mediated gene amplification 显示文摘 | Jun SC Kim MS Hong HJ | 2006 | Biotechnol Prog2006，22，3： | 1 |
| 6 | Region - specific Phosphorylation of ERK5 - MEF2C in the Rat Frontal Cortex and Hippocampus after Elec- troconvulsive Shock 显示文摘 | Yoon SC Ahn YM Jun SJ | 2005 | Ping Neuropsychopharmacol Biol Psychia try2005，29，5： | 1 |
| 7 | Ameliorative effects of pycnogenol on carton tetrachloride-induced hepatic oxidative damage in rats显示文摘 | Ahn TH Yang YS Lee JC Moon CJ Kim SH Jun W Park SC Kim JC | | 0，，21： | 1 |
| 8 | Single-balloon kypho- plasty in osteoporotic vertebral compression fractures: Far-lateral extrapedicular approach显示文摘 | Ryu KS Huh HY Jun SC | 2009 | J Korean Neurosurg Soc2009，45，2： | 1 |
| 9 | Spectral embedding based active contour (SEAC) for lesion segmentation on breast dynamic contrast enhanced magnetic resonance imaging显示文摘 | Agner SC Xu Jun Madabhushi A | 2013 | Medical Physics2013，40，： | 1 |
| 10 | Region-specific phosphorylafion of ERKS-MEF2C in the rat frontal codex and hippocampus after electroconvulsive shock 显示文摘 | Yoon SC Alan YM Jun sJ | 2005 | Ping Neuro-psychopharmacol Biol Psychiatry2005，29，5： | 1 |
| 11 | Single-balloon kyphoplas- ty in osteoporotic vertebral compression fractures:far-lat- eral extrapedicular approach 显示文摘 | Ryu KS Huh HY Jun SC | 2009 | J Korean Neurosurg Soc2009，45，2： | 1 |
| 12 | Region-specific phosphorylation of ERKS-MEF2C in the rat frontal cortex and hippocampus after electroconvulsive shock 显示文摘 | Yoon SC Ahn YM Jun S J | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，5： | 1 |
| 13 | Relation of Plasma Homocyst(e) ine to Cerebral Infarction and Cerebral Atheroselerosis 显示文摘 | Jun HY Chin SC | 1998 | Stroke1998，29，12： | 1 |
| 14 | Region-specific Phosphorylation of ERK5-MEF2C in the Rat Frontal Cortex and Hippocampus after Electroconvulsive Shock显示文摘 | YOON SC AHN YM JUN SJ | 2005 | Prog Neuropsychopharmacol Biol Psychiatry( S0278 - 5846)2005，29，5： | 1 |
| 15 | A highly active and stable catalyst for carbon dioxide reforming of methane:Ni/Ce-ZrO2/θ-Al2O3显示文摘 | Rob HS Jun KW Back SC etal | 2002 | Catal Lett2002，81，： | 1 |
| 16 | Inhibition of nNOS and COX-2 expression by lutein in acute retinal ischemia显示文摘 | Jun SC Dongmyung K Yeon MH | 2006 | Nutrition2006，22，8： | 1 |
| 17 | Single-balloon kyphoplasty in os- teoporotic vertebral compression fractures:far-lateral extrapedicular approach 显示文摘 | Ryu KS Huh HY Jun SC | 2009 | J Korean Neurosurg Soc2009，45，2： | 1 |
| 18 | Region-specific phosphorylation of ERK5-MEF2C in the rat frontal cortex and hippocampus after electroconvulsive shock显示文摘 | Yoon SC Ahn YM Jun SJ | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，5： | 1 |
| 19 | Region-specific Phosphorylation of ERK5 - MEF2C in the Rat Frontal Cortex and Hippecampus after Electroconvulsive Shock 显示文摘 | Yoon Sc Ahn YM Jun SJ | 2005 | Prog Neuropsychopharmacol Biol Psychia try (S078-5846)2005，29，5： | 1 |
| 20 | Occupational stress and physical symptoms among family medicine residents 显示文摘 | Myung SC Yong SP Jun HY | 2013 | Korean J Fam Med2013，34，： | 1 |
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