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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Effects of pH on heavy metal sorption on mineral apatite显示文摘 | Chen XB Judith V James LC | 1997 | Environmental Science & Technology1997，31，3： | 1 |
| 4 | Effects of crosslinker on the morphology and properties of microgels containing N- vinylfornlamide, glycidyhnethacrylate and vinylamine 显示文摘 | Judith McCann Sineena Thaiboonrod Rein V | 2014 | Journal of Colloid and Interface Science2014，415，： | 1 |
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| 6 | Recovery of polyphenols from the by-products of plant food processing and application as valuable food ingredients显示文摘 | DIETMAR R K JUDITH K REGINE V | 2014 | Food Research International2014，，： | 1 |
| 7 | Preparation of Photonic Crystals Made of Air Spheres in Titania显示文摘 | Wijndhoven J Judith E G Willem L V | 1998 | Seienee1998，，281： | 1 |
| 8 | A Novel Role of Complement Factor Clq in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8^+ T Lymphocytes 显示文摘 | Monffoort N V Judith M H Sehuurhuis D H | 2007 | The Journal of Immunology2007，178，6： | 1 |
| 9 | Simple sugars, oligosaccharides and starch concentrations in raw and cooked sweet potato 显示文摘 | Truong V D Christopher J B Judith A M | 1986 | Journal of Agricultural and Food Chemistry1986，34，3： | 1 |
| 10 | Evaluation of heavy metal remediation using mineral apatite显示文摘 | Chen Xiaobing Judith V Wright | 1997 | Water Air and Soil Pollution1997，98，： | 1 |
| 11 | Associations of polycyclic organic matter in outdoor air with decreased birth weight:a pilot cross-sectional analysis显示文摘 | Zdravko P V Mark G R Judith B K | 2001 | Journal of Toxicology and Environmental Health2001，64，： | 1 |
| 12 | A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation显示文摘 | JUDITH T C AMADIO V MART S | 2003 | Journal of Neuroscience Methods2003，125，： | 1 |
| 13 | Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei显示文摘 | Ana Judith Cáceres Paul A.M. Michels Véronique Hannaert | 2009 | Molecular & Biochemical Parasitology2009，，1： | 1 |
| 14 | Indirect Health Effects of Relative Humidity in Indoor Environments显示文摘 | Anthony V Arundel Elia M Sterling Judith H Biggin | 1986 | Environment Health Perspectives1986，，65： | 1 |
| 15 | Lipid profiles of persons with paraplegia and tetraplegia:sex differences显示文摘 | Andreas S Judith K Stefan V | 2008 | J Spinal Cord Med2008，31，3： | 1 |
| 16 | Preparation of photonic crystals made of air spheres in titania显示文摘 | Wijndhoven J Judith E G Willem L V | 1998 | Science1998，281，5378： | 1 |
| 17 | Lack of prognostic relevance of Her-2/neu, topoisomerase IIα and EGFRin advanced ovarian carcinoma显示文摘 | Verena Engelstaedter Judith Boda Christine V?lklein Jutta Engel Udo Jeschke Thomas Kirchner Doris Mayr | 2012 | Experimental and Therapeutic Medicine2012，，5： | 1 |
| 18 | A Novel role of eomplement factor Clq in augmenting the presentation of antigen cap tured in immune complexes to CD8^+ T lymphocytes显示文摘 | Montfoort N V Judith M H Schuurhuis D H | 2007 | J Immunol2007，178，6： | 1 |
| 19 | Impact of Herpes Simplex Virus Type 2 on HIV-1 Acquisition and Progression in an HIV Vaccine Trial (the Step Study)显示文摘 | Ruanne V Barnabas Judith N Wasserheit Yunda Huang Holly Janes Rhoda Morrow Jonathan Fuchs Karen E Mark Martin Casapia Devan V Mehrotra Susan P Buchbinder Lawrence Corey | 2011 | JAIDS Journal of Acquired Immune Deficiency Syndromes2011，，： | 1 |
| 20 | Antibacterial activity of silver nanoparticies synthesized from serine显示文摘 | Jayaprakash N Judith V J John K L | 2015 | Materials Science and EngineeringC2015，49，： | 1 |
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