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| 1 | Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis显示文摘Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with numerous spectacular innovations.To search for the molecular connections involved,we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans.We focused on gametes and early embryos,where the methylomes are known to evolve divergently between fish and mammals.Here,we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects,but clearly presents in deuterostomes such as echinoderms and invertebrate chordates,and then becomes more evident in vertebrates.Functional association analysis suggests that DNA methylation reprogramming is associated with development,reproduction and adaptive immunity for vertebrates,but not for invertebrates.Interestingly,the single HOX cluster of invertebrates maintains unmethylated status in all stages examined.In contrast,the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis.Notably,the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals.Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution,especially after the evolutionary transitions from invertebrates to vertebrates,and then to mammals. | Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David KSimmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong EZhang Mark QMartindale Jiang Liu | 2019 | National Science Review2019，6，5： | 2 |
| 2 | Significant loss of soil inorganic carbon at the continental scale显示文摘Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and CO_(2) release.However,to date,few studies have addressed these processes.Here,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC)stocks in China.We observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m^(-2)yr^(-1))from the 1980s to the 2010s.Total SIC stocks have decreased by∼8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr^(-1))and in cropland(0.016 Pg C yr^(-1))account for∼17.6%-24.0%of the terrestrial C sink and 57.1%of the soil organic carbon sink in cropland,respectively.Nitrogen deposition and climate change have profound influences on SIC cycling.We estimate that∼19.12%-19.47%of SIC stocks will be further lost by 2100.The consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss. | Xiao-Dong Song Fei Yang Hua-Yong Wu Jing Zhang De-Cheng Li Feng Liu Yu-Guo Zhao Jin-Ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing Wang Ke-Ning Wu Feng-Rong Zhang Ming-Kui Zhang Zhou Shi Wan-Zhu Ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang Yuan Yang-Zhu Zhang Jun-Ping Bai Jia-Ying Chen Jie Chen Yin-Jun Chen Yun-Zhong Dong Chun-Lan Han Ling Li Li-Ming Liu Jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-Feng Wang Tian-Wei Wang Xiang-Hua Wei Hong-Qi Wu Xia Zhao Qing Zhou Gan-Lin Zhang | 2022 | National Science Review2022，9，2： | 2 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | The role of bone cement aug- mentation in the treatment of chronic symptomatic osteo porotic compression fracture显示文摘 | Kim HS Kim SH Ju CI | 2010 | J Korean Neurosurg Soc2010，48，6： | 1 |
| 5 | Strategies for noncontained lumbar disc herniation by an endoscopic approach:transforaminal suprapedicular approach,semi-regid flexible curve probe,and 3-dimensional reconstruction CT with discogram显示文摘 | Chae KH Ju CI Lee SM | | 0，，04： | 1 |
| 6 | Paraspinal muscle sparing versus per- cutaneous screw fixation:a prospective and comparative study for the treatment of L5 - S1 spondylolisthesis 显示文摘 | Jang KS Kim HS Ju CI | 2011 | J Korean Neurosurg Soc2011，3，： | 1 |
| 7 | WNT-β-catenin signaling pathway and its relationship with cancer显示文摘 | Ochoa-Hernández AB Juárez-Vázquez CI Rosales-Reynoso MA | 2013 | Cir Cir2013，80，4： | 1 |
| 8 | WNT-β-catenin signaling pathway and its relationship with cancer显示文摘 | Ochoa-Hernández AB Juárez-Vázquez CI Rosales-Reynoso MA | | 0，，4： | 1 |
| 9 | Screw fixation without fusion for low lumbar burst fracture : a severe canal compromise but neurologically intact case 显示文摘 | Jang KS Ju CI Kim SW | 2011 | J Korean Neurosurg Soc2011，49，2： | 1 |
| 10 | Delayed bone cement displacement following balloon kyphoplasty显示文摘 | Wang HS Kim HS Ju CI | 2008 | J Kore- an Neurosurg Soc2008，43，4： | 1 |
| 11 | Delayed bone cement displace ment following balloon kyphoplasty 显示文摘 | Wang HS Kim HS Ju CI | 2008 | J Korean Neurosurg Soo2008，43，4： | 1 |
| 12 | Screw fixation without fusion for lowlumbar burst fracture: a severe canal compromise but neurologically intact case显示文摘 | Jang KS Ju CI Kim SW | 2011 | J Korean Neurosurg Soc2011，49，2： | 1 |
| 13 | Endoscopic transforaminal suprape- dicular approach in high grade inferior migrated lumbar disc herni- ation显示文摘 | Kim HS Ju CI Kim SW | 2009 | J Korean Neurosurg Soc2009，45，2： | 1 |
| 14 | Huge psoas muscle hemaloma due to lumbar segmental vessel injury following percutaneous en- doscopic lumbar diseeetomy 显示文摘 | Kim HS Ju CI Kim SW | 2009 | J Korean Neurosurg Soc2009，45，3： | 1 |
| 15 | The role of bone cement augmentation in the treatment of chronic symptomatic osteoporotic compression fracture显示文摘 | Kim HS Kim SH Ju CI | | 0，，06： | 1 |
| 16 | Strategies for noncontained lumbar disc herniation by an endoscopic approach: transforaminal suprape- dicular approach, semi-rigid flexible curved probe, and 3-dimensional reconstruction CT with discogram 显示文摘 | Chae KH Ju CI Lee SM | 2009 | J Korean Neurosurg Soc2009，46，4： | 1 |
| 17 | Sacral perineural cyst accompanying disc herniation显示文摘 | Ju CI Shin H Kim SW | 2009 | J Korean Neurosurg Soc2009，45，3： | 1 |
| 18 | Therapy of type 1 diabetes with CD4 + CD25 high CD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up显示文摘 | Natalia Marek-Trzonkowska Ma?gorzata My?liwiec Anita Dobyszuk Marcelina Grabowska Ilona Derkowska Jolanta Ju?cińska Rados?aw Owczuk Agnieszka Szadkowska Piotr Witkowski Wojciech M?ynarski Przemys?awa Jarosz-Chobot Artur Bossowski Janusz Siebert Piotr Trzo | 2014 | Clinical Immunology2014，，1： | 1 |
| 19 | Huge psoas muscle hematomadue to lumbar segmental vessel injury following percutaneous endo-scopic lumbar discectomy显示文摘 | Kim HS Ju CI Kim SW | | 0，，03： | 1 |
| 20 | Minimally invasive percutaneous endoscopic 2 levels adjacent lumbar discectomy through I portal skin incision: Preliminary study显示文摘 | Kim HS Ju CI Kim SW | 2015 | Asian J Neurosurg2015，10，2： | 1 |
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