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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis显示文摘 | Zheng, ZY Lee, AW Zhan, XB Shi, Z Wang, L Zhu, L Wu, JR Lin, CC | 2007 | 中国生物学文摘2007，21，10： | 13 |
| 3 | Mechanisms of closure of perimembranous ventricular septal defect 显示文摘 | Anderson RH Lenox CC Znberbuhler JR | 1983 | Am J Cardiol1983，53，： | 1 |
| 4 | Ablative techniques for hepatocellular carcinoma 显示文摘 | Barnett CC Jr Curley SA | 2001 | Semin Oncol2001，28，5： | 1 |
| 5 | Oause and prevention of electrosuygical injuries in laparoscopy显示文摘 | Nduka CC Super PA Monson JR | 1994 | J Am Coil Surg1994，179，2： | 1 |
| 6 | Malignant pleu- ral mesothelioma : a comprehensive review 显示文摘 | Ismail-Khan R Robinson LA Williams CC Jr | 2006 | Cancer Control2006，13，4： | 1 |
| 7 | Effects of Nurse- Managed Protocols in the Outpatient Management of Adults With Chronic Conditions A Systematic Review and Meta- analysis 显示文摘 | Shaw RJ McDuffie JR Hendrix CC | 2014 | Ann Intern Med2014，161，2： | 1 |
| 8 | The Pharmacokinetics of re mifentaniI显示文摘 | I Michelsen LG Hug CC Jr | 1996 | JClin Anesth1996，8，： | 1 |
| 9 | Distribution of central corneal thickness and its association with intraocular pressure显示文摘 | Wolfs RC Klaver CC Vingerling JR | 1997 | Am J Ophthalmol1997，123，6： | 1 |
| 10 | Management and return to play of stress fractures显示文摘 | Kaeding CC Yu JR Wright R | | 0，，06： | 1 |
| 11 | Proteomic analysis of two functional states of the Golgi complex in mammary epithelial cells显示文摘 | Wu CC Yates JR 3rd Neville MC | | 0，，： | 1 |
| 12 | Distribution of central corneal thickness and its association with intraocular pressure:the Rotterdam study显示文摘 | Wolfs RC Klaver CC Vingerling JR | 1997 | Am J Ophthalmol1997，123，： | 1 |
| 13 | Type I interferons protect mice against enterovirus 71 infection 显示文摘 | Liu ML Lee YP Wang YF Lei HY Liu CC Wang SM Su IJ Wang JR Yeh TM Chen SH Yu CK | 2005 | J Gen Virol2005，86，12： | 1 |
| 14 | Limitations of size as a criterion in the evaluation of adrenal tumors 显示文摘 | Barnett CC Jr Varma DG El-Naggar AK | 2000 | Surgery2000，128，6： | 1 |
| 15 | Comparison of practical methods for urinary glycosaminoglycans and serum hyaluronan w ith clinical activity scores in patients w ith Grave’s ophthalmopathy显示文摘 | Martins JR Furlanetto RP Oliveira LM Mendes A Passerotti CC Chiamolera MI | 2004 | Clin Endocrinol2004，60，6： | 1 |
| 16 | Distribution of central co-rneal thickness and its association with intraocular pressure:the Rotterdam Study显示文摘 | Wolfs RC Klaver CC Vingerling JR | 1997 | Am J Ophthalmol1997，123，： | 1 |
| 17 | Mapping of the central sulcus with functional MR:active versus passive activation tasks显示文摘 | Lee CC Jack CR Jr Riederer SJ | 1998 | AJNR1998，19，5： | 1 |
| 18 | Evaluation of sufentanil anes- thesia obtained by a computer-controlled infusion for cardiac sur- gery 显示文摘 | Bailey JM Schweiger IM Hug CC Jr | 2010 | Anesth Analg2010，76，2： | 1 |
| 19 | Development of a membrane array-based multimarker assay for detection of circulating cancer cells in patients with non small cell lung cancer 显示文摘 | Sheu CC Yu YP Tsai JR | 2006 | Int J Cancer2006，119，6： | 1 |
| 20 | Sequencing and analysis of four new Enterobacter ampD genes of Cirtrobacter freundii and Enterobacter cloacae显示文摘 | Ehrhardt AF Sanders CC Romero JR | 1996 | Antimicrob Agents Chemother1996，40，： | 1 |
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