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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 4 | Incidence and Morphology of the Posteromedial Fragment in Bicondylar Tibial Plateau Fractures显示文摘 | Thomas F Higgins Dan Kemper Joshua Klatt | 2009 | Journal of Orthopaedic Trauma2009，，1： | 2 |
| 5 | Variations in microbial community composition through two soil depth profiles显示文摘 | NOAH F JOSHUA P S PATRICIA A H | 2003 | Soil Biol Biochem2003，35，1： | 1 |
| 6 | Variations in microbial communitycomposition through two soil depth profiles显示文摘 | NOAH F JOSHUA P S PATRICIA A H | 2003 | Soil Biology and Biochemistry2003，35，1： | 1 |
| 7 | An Empirical Study of Smoothing Techniques for Language Modeling显示文摘 | Stanley F Chen Joshua Goodman | 1996 | In proceedings of the 34th Annual Meeting of the ACL1996，，： | 1 |
| 8 | Training and calibration improve inter-reader reliability of joint damage assessment using magnetic resonance image scoring and computerized erosion volume measurement显示文摘 | Bird P Joshua F Lassere M | 2005 | J Rheumatol2005，32，8： | 1 |
| 9 | Potential beneficial metabolic interactions between tamoxifen and isoflavones via cytochrome P450-mediated pathways in female rat liver microsomes显示文摘 | Chen J Steven C H Joshua F A | 2004 | Pharm Res2004，21，11： | 1 |
| 10 | Control of green and red upconversion in NaYF4:Yb3+,Er3+ nanoparticles by excitation modulation显示文摘 | Gainer C F Joshua G S de Silva C R | | 0，，46： | 1 |
| 11 | Air quality during the 2008 Bering Olympic Games显示文摘 | Streets D G Joshua S F Carey J J | 2007 | Atmospheric Environment2007，41，3： | 1 |
| 12 | Variations in microbialcommunity composition through two soil depth profiles显示文摘 | Noah F Joshua P S Patricia A H | 2003 | Soil Biology and Biochemistry2003，35，16： | 1 |
| 13 | Face rec- ognition performance : role of demographic information 显示文摘 | Brenda F K Mark J B Joshua C K | 2012 | IEEE Transactions on Information Forensics and Security2012，7，6： | 1 |
| 14 | Certainty and Discretion in Planning Control: A Case Study of Office Development in Hong Kong显示文摘 | Tang Bo-Sin Lemon H T Choy Joshua K F Wat | 2000 | Urban Studies2000，，13： | 1 |
| 15 | Strand spaces:Proving security protocols correct显示文摘 | Javier Thayer Fábrega F Jonathan C Herzog Joshua D Guttman | 1999 | Journal of Computer Security1999，7，23： | 1 |
| 16 | Spiekerman,Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders显示文摘 | Barzilay Charles F | 2001 | Diabetes care2001，24，7： | 1 |
| 17 | Variations in microbial community composition through two soil depth profiles 显示文摘 | Noah F Joshua P S Patricia A H | 2003 | Soil Biology and Biochemistry2003，，35： | 1 |
| 18 | Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures显示文摘BACKGROUND The healthcare burden of inflammatory bowel disease(IBD)is rising globally and there are limited non-invasive biomarkers for accurate and early diagnosis.AIM To understand the important role that intestinal microbiota play in IBD pathogenesis and identify anti-microbial antibody signatures that benefit clinical management of IBD patients.METHODS We performed serological profiling of 100 Crohn’s disease(CD)patients,100 ulcerative colitis(UC)patients and 100 healthy controls against 1173 bacterial and 397 viral proteins from 50 bacteria and 33 viruses on protein microarrays.The study subjects were randomly divided into discovery(n=150)and validation(n=150)sets.Statistical analysis was performed using R packages.RESULTS Anti-bacterial antibody responses showed greater differential prevalence among the three subject groups than anti-viral antibody responses.We identified novel antibodies against the antigens of Bacteroidetes vulgatus(BVU_0562)and Streptococcus pneumoniae(SP_1992)showing higher prevalence in CD patients relative to healthy controls.We also identified antibodies against the antigen of Streptococcus pyogenes(SPy_2009)showing higher prevalence in healthy controls relative to UC patients.Using these novel antibodies,we built biomarker panels with area under the curve(AUC)of 0.81,0.87,and 0.82 distinguishing CD vs control,UC vs control,and CD vs UC,respectively.Subgroup analysis revealed that penetrating CD behavior,colonic CD location,CD patients with a history of surgery,and extensive UC exhibited highest antibody prevalence among all patients.We demonstrated that autoantibodies and anti-microbial antibodies in CD patients had minimal correlation.CONCLUSION We have identified antibody signatures for CD and UC using a comprehensive analysis of antimicrobial antibody response in IBD.These antibodies and the source microorganisms of their target antigens improve our understanding of the role of specific microorganisms in IBD pathogenesis and,after future validation,should aid early and accurate diagnosis of IBD. | Mahasish Shome Lusheng Song Stacy Williams Yunro Chung Vel Murugan Jin G Park William Faubion Shabana F Pasha Jonathan A Leighton Joshua LaBaer Ji Qiu | 2022 | World Journal of Gastroenterology2022，28，30： | 1 |
| 19 | Vanillin-based resin for use in composite applications显示文摘 | Joseph F Stanzione Joshua M Sadler John J La Scala | 2012 | Green Chem2012，14，： | 1 |
| 20 | Three-dimensional analysis of the internal mammary artery perforator flap显示文摘 | Joshua A Gillis VP Steven F | 2011 | Plast Reconstr Surg2011，128，5： | 1 |
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