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| 1 | Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats显示文摘Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension. | Théophile Dimo Fidèle Ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 2 |
| 2 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 3 | Effect of Tai Chi on physical function, fall rates and quality of life among older stroke survivors显示文摘 | Ruth ET Tiffany MH Joseph TH | 2014 | Archives Physical Medicine Rehabilitation2014，95，5： | 1 |
| 4 | Automatic registration of ERS and SPOT multisensor images in a data fusion context显示文摘 | Olivier Thépaut Kidiyo Kpalma Joseph Ronsin | 2000 | Forest Ecology and Management2000，128，： | 1 |
| 5 | Can clinical pharmacy services have a positive impact on drug-related problems and health outcomes in community- based older adults显示文摘 | Joseph TH Catherine IL Shelly LG | 2004 | American Journal of Geriatric Pharmacotherapy2004，2，1： | 1 |
| 6 | Effect of paroxetine hydrochloride(Paxil) on fatigue and depression in breastcancer patients receiving chemotherapy显示文摘 | Joseph AR Gary RM Jane TH | 2005 | Breast Cancer Res Treat2005，89，： | 1 |
| 7 | Physiological basis of UV-C induced resistance to Botrytis cinerea in tomato fruit. V. Constitutive defence enzymes and inducible pathogenesis-related proteins显示文摘 | Marie Thérèse Charles Kablan Tano Alain Asselin Joseph Arul | 2008 | Postharvest Biology and Technology2008，，3： | 1 |
| 8 | Long-term outcome of 254 complex incisional hernia repairs using the modified Rives-Stoppa technique显示文摘 | Iqbal CW Pham TH Joseph A | 2007 | World J Surg2007，31，12： | 1 |
| 9 | Apoptosis-inducing factor determines the chemoresistance of non-smallcell lung carcinomas显示文摘 | Gallego MA Joseph B Hemstrom TH | 2004 | Oncogene2004，23，37： | 1 |
| 10 | Tissue engineering显示文摘 | Robert Langer Joseph P Vacanti TH | 1993 | Science1993，260，5110： | 1 |
| 11 | Effect of paroxetine hydrochloride(Paxil) on fatigue and depression in breastcancer patients receiving chemotherapy显示文摘 | Joseph AR Gary RM Jane TH | 2005 | Breast Cancer Res Treat2005，89，： | 1 |
| 12 | Cognitive profiles and social-communicative functioning in children with autism spectrum disorder显示文摘 | Joseph RM Flusberg TH Lord C | 2002 | J Child Psychol Psyc2002，43，6： | 1 |
| 13 | 3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: A novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity显示文摘 | Umashankar Das Masami Kawase Hiroshi Sakagami Atsushi Ideo Jun Shimada Joseph Molnár Zoltán Baráth Zsuzsanna Bata Jonathan R. Dimmock | 2007 | Bioorganic & Medicinal Chemistry2007，，10： | 1 |
| 14 | PKC412 sensitizes U1810 non-small-cell lung cancer cells to DNA damage显示文摘 | Hemstrm TH Joseph B Schulte G | 2005 | Exp Cell Res2005，305，1： | 1 |
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