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| 1 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 2 | Improved recoverability of microbial colonies from marine sponge samples显示文摘 | Olson J B Lord C C McCarthy P J | 2000 | Microbial Ecology2000，40，： | 1 |
| 3 | Implicit Leadership Theory: A Potential Threat to the Internal Validity of Leader Behavior显示文摘 | Lord Rush Michael C | 1977 | Organizational Behavior & Human Performance1977，20，1： | 1 |
| 4 | Exercise therapy for prevention of falls in people with Parkinson's disease: a protocol for a randomised controlled trial and economicevaluation显示文摘 | Canning CG Sherrington C Lord SR | 2009 | BMC Neurol2009，2294，： | 1 |
| 5 | The DNA damage response and cancer therapy显示文摘 | Lord C J Ashworth A | | 0，，： | 1 |
| 6 | The relationship of motor sells and adaptive behavior skills in young children with autism spectrum disorders显示文摘 | MacDonald M Lord C Ulrich D | | 0，，07： | 1 |
| 7 | Effects of child characteristics on the autism diagnostic interview-revised:implications for use of scores as a measure of ASD severity 显示文摘 | Hus V Lord C | 2013 | J Autism Dev Disord2013，43，2： | 1 |
| 8 | Failure of IMV-16 as second-line treatment for relapsed or refractory high grade Non-Hodgkin's Lymphoma显示文摘 | Newland AC Linch DC | 1992 | Hematol Oncol1992，10，2： | 1 |
| 9 | Dynamic characteristics of a base isolated building from ambient vibration measurements and low level earthquake shaking 显示文摘 | Ventura C E Liam F W D Lord J F | 2003 | Soil Dynamics and Earthquake Engineering2003，23，4： | 1 |
| 10 | NLK is a novel therapeutic target for PTEN deficient tumour cells显示文摘 | Mendes-Pereira A M Lord C J Ashworth A | 2012 | PLoS One2012，7，47： | 1 |
| 11 | Evaluation of quantitative PCR reference genes for gene expression studies in Tribolium castaneum after fungal challenge显示文摘 | Lord J C Hartzer K Toutges M | | 0，，02： | 1 |
| 12 | Mangy mutt or furry friend?Anthropomorphism promotes animal welfare显示文摘 | Butterfield M E Hill S E Lord C G | 2012 | Journal of Experimental Social Psychology2012，48，4： | 1 |
| 13 | Dynamic characteristics of a base isolated building from ambient vibration measurements and low level earthquake shaking显示文摘 | Ventura C E Liam Finn W D Lord J F | 2003 | Soil Dynamics and Earthquake Engineering2003，23，： | 1 |
| 14 | Utilizing RNA interference to enhance cancer drug discovery显示文摘 | Iorns E Lord C J Turner N | 2007 | Nat Rev Drug Discov2007，6，7： | 1 |
| 15 | Therapeutic targeting of the DNA mismatch repair pathway 显示文摘 | Martin SA Lord C J Ashworth A | 2010 | Clin Cancer Res2010，16，21： | 1 |
| 16 | Sampling technique to discriminate the different tissue layers of growing antler tips for gene discovery显示文摘 | Li C Clark D E Lord E A | 2002 | Anat Rec2002，268，2： | 1 |
| 17 | Sampling technique to discriminate the different tissue layers of growing antler tips for gene discovery显示文摘 | Li C Clark D E Lord E A | 2002 | Anat Rec2002，268，2： | 1 |
| 18 | Transgenerational effects of preconception paternal contamination with (55)Fe显示文摘 | Hoyes KP Lord BI McCann C | 2001 | Radiat Res2001，156，51： | 1 |
| 19 | Identification of phenobarbitone-modulated genes in mouse liver by differential display显示文摘 | GARCIA-ALLAN C LORD PG LOUGHLIN JM | 2000 | J Biochem Mol Toxicol2000，14，1： | 1 |
| 20 | Diagnosing autism:analyses of data fi'om the autism diagnostic interview 显示文摘 | Lord C Pickles A McLennan J | 1997 | J Autism Dev Disord1997，27，5： | 1 |
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