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| 1 | 慢性淋巴细胞白血病诊治指南显示文摘流行病学
慢性淋巴细胞白血病(CLL)在西方国家很常见,占65岁以上白血病患者的65%.中位发病年龄65~70岁.30岁以下极为罕见,但20%~30%病例于55岁前发病,年发病率约3/10万.欧洲、澳大利亚、北美白人以及黑人的发病率是印度、中国及日本的20~30倍.男女之比约2:1.无确凿证据显示,接触化学物质和射线、饮食、吸烟、病毒感染和自身免疫性疾病为本病的高危因素,但患者一级和二级亲属淋巴系统恶性肿瘤发病率增高.许多家族尚存在患者后代发病年龄更早、病情更重的现象.经治和未治患者第二肿瘤发病率增高. | Oscier D Fegan C Hillman P Illide T Johnson S Maguir P Matutes M Milligan D 孙蕾 高举 | 2005 | 国外医学(输血及血液学分册)2005，28，1： | 6 |
| 2 | HMGA蛋白在恶性外周神经鞘膜肿瘤和滑膜肉瘤中的表达显示文摘 | Hui P Li N Johnson C 黄文斌(摘译) 陈洁宇(摘译) 周晓军(审校) | 2005 | 临床与实验病理学杂志2005，21，6： | 4 |
| 3 | Electrochemical extraction of lithium from LiMn2O4 显示文摘 | Thackeray M M Johnson P J | 1984 | Mater Res Bull1984，19，： | 2 |
| 4 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 5 | CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia显示文摘AIM:To compare the sensitivity and specificity of CDX2 and alcian blue(AB) p H 2.5 staining in identifying esophageal intestinal metaplasia.METHODS:One hundred and ninty-nine biopsies from 186 patients were retrospectively reviewed and categorized as Barrett's esophagus(BE)(n =108); non-Barrett's esophagus(NBE)(n =48); columnar blue cells(CB) and esophageal glands(EG)(n =43).The biopsies were stained with AB and immunostained for CDX2 using a mouse monoclonal antibody from Biogenex(clone CDX2-88) and the Ventana Discovery X automated immunostainer.The positive and negative predictive value of each group was used to determine the predictive power of CDX2 and AB in diagnosing intestinal metaplasia.RESULTS:All of the 108 BE biopsies(100%) were positive for AB and 102 of them(94.4%) were positive for CDX2.The six BE patients(5.6%) who failed to stain with CDX2 were found to have lost the focus of intestinal metaplasia upon deeper sectioning for immunostaining.Both AB and CDX2 were negative in 43 out of 48(89.6%) NBE cases.Five NBE patients(10.4%) were falsely positive for AB due to the presence of EG and CB in these biopsies.These cases were all CDX2 negative.In addition,5 AB negative NBE were found to be CDX2 positive.Based on these results the CDX2 immunostain had similar sensitivity but higher specificity(100% vs about 91%) than AB in detecting intestinal type metaplasia in these samples.Our data shows that CDX2 has a better PPV in detecting intestinal metaplasia as compared to AB(95.6% vs 71.5%,respectively).CONCLUSION:CDX2 has a better positive predictive value than AB in detecting intestinal metaplasia.CDX2may be useful when challenged by gastro-esophageal biopsies containing mimikers of BE. | Dennis R Johnson Maisoun Abdelbaqui Maryam Tahmasbi Zoltan Mayer Hung-Wei Lee Mokenge P Malafa Domenico Coppola | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 6 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 7 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 8 | Storage of boar semen显示文摘 | L.A Johnson K.F Weitze P Fiser W.M.C Maxwell | 2000 | Animal Reproduction Science2000，，1： | 2 |
| 9 | Immunohistochemical detection and distribution of the 1,25-dihydroxyvltamin D3 receptor in rat reproductive tissues显示文摘 | JOHNSON J A GRANDE J P ROCHE P C | 1996 | Histochem Cell Biol1996，105，1： | 1 |
| 10 | Storage of boar semen显示文摘 | Johnson I A Weitze K F Fiser P | 2000 | Animal Reproduction Scierce2000，62，13： | 1 |
| 11 | A method for estimation the sub-wavelength sway of a sonar towfish显示文摘 | HAYES M P COUGH P T | 1995 | IEEE OE1995，20，4： | 1 |
| 12 | Piloquinone:a new phenanthreme-O-quinone isolated from the mycelium of Streptomyces pilosus显示文摘 | Polonsky J Cohen P | 1963 | Nature1963，，199： | 1 |
| 13 | Crenarchaeotal lipids in lake sediments: A new paleotemperature proxy for continental paleoclimate reconstruction? 显示文摘 | Powers L A Werne J P Johnson T C | 2004 | Geology2004，32，： | 1 |
| 14 | Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats显示文摘 | BIZEAU M E MACLEAN P S JOHNSON G C | 2003 | The Journal of Nutrition2003，133，： | 1 |
| 15 | A new peritoneal carcinomatosis model in cyclosporine immunosuppressed rats 显示文摘 | Akhter J Yao P Johnson LA | 2008 | Anticancer Resarch2008，28，1： | 1 |
| 16 | Frictional-collisional constitutive relations for granular materials, with application to plane shearing 显示文摘 | Johnson P C Jackson R | 1987 | Journal of Fluid Mechanics1987，176，： | 1 |
| 17 | Shock-wave initiation of heterogeneous reactive solids显示文摘 | Johnson J N Tang P K Forest C A | 1985 | J Appl Phys1985，57，9： | 1 |
| 18 | Peanut hull pel- lets as a single use sorbent for the capture of Cu( Ⅱ )from wastewater 显示文摘 | Johnson P D Watson M A Brown J | 2002 | Waste Management2002，22，5： | 1 |
| 19 | Anambulatory surgical procedure under local anesthesia for treatment of female urinary incontinence显示文摘 | Ulmsten U Henriksson L Johnson P | 1996 | Int Urogynecol J1996，7，： | 1 |
| 20 | Combinatorial infection and in vivo recombination:a strategy for making large phage antibody repertoires 显示文摘 | Waterhouse P Griffiths A D Johnson K S | 1993 | Nucleic Acids Research1993，21，： | 1 |
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