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| 1 | 慢性淋巴细胞白血病诊治指南显示文摘流行病学
慢性淋巴细胞白血病(CLL)在西方国家很常见,占65岁以上白血病患者的65%.中位发病年龄65~70岁.30岁以下极为罕见,但20%~30%病例于55岁前发病,年发病率约3/10万.欧洲、澳大利亚、北美白人以及黑人的发病率是印度、中国及日本的20~30倍.男女之比约2:1.无确凿证据显示,接触化学物质和射线、饮食、吸烟、病毒感染和自身免疫性疾病为本病的高危因素,但患者一级和二级亲属淋巴系统恶性肿瘤发病率增高.许多家族尚存在患者后代发病年龄更早、病情更重的现象.经治和未治患者第二肿瘤发病率增高. | Oscier D Fegan C Hillman P Illide T Johnson S Maguir P Matutes M Milligan D 孙蕾 高举 | 2005 | 国外医学(输血及血液学分册)2005，28，1： | 6 |
| 2 | P2X4受体对活化的小胶质细胞的调控作用显示文摘小胶质细胞是中枢神经系统内的免疫细胞,当脑组织出现损伤时,小胶质细胞被激活,对脑组织起到保护作用。在自身免疫性脑脊髓炎模型大鼠和视神经脊髓炎患者体内,均观察到在脊髓炎性病灶及小胶质细胞内,P2X4受体表达上调。本课题组进行在体和离体实验,用LPS活化小胶质细胞,观察P2X4受体在小胶质细胞炎性反应中的作用。膜片钳检测显示,在LPS激活的小胶质细胞内,P2X4受体活性增加。P2X4受体阻断剂可显著降低小胶质细胞的膜皱缩、TNFα的分泌、细胞形态的改变及LPS导致的小胶质细胞死亡。在体研究显示,LPS髓内注射后会诱发炎性反应,迅速导致小胶质细胞丢失;给予P2X4受体阻断剂可显著减少小胶质细胞的丢失,而P2X4受体激活剂则可显著增加小胶质细胞的丢失。海马齿状回的小胶质细胞特别容易被LPS诱导的炎症反应激活。注射LPS后2 h,位于海马齿状回的小胶质细胞即被激活,大约24 h后死亡,P2X4受体阻断剂可减少LPS诱导的小胶质细胞活化和死亡。上述数据提示,P2X4受体对于小胶质细胞的激活和存活有重要的调控作用。 | Vázquez-Villoldo N Domercq M Martín A Llop J Gómez-Vallejo V Matute C | 2014 | 神经损伤与功能重建2014，9，1： | 4 |
| 3 | Lineage commitment in biphenotypic acute leukemia 显示文摘 | BUCCHERI V MATUTES E DYER M | 1993 | Leukemia1993，7，： | 1 |
| 4 | Corporate Social Responsibility as a Vehicle to Reveal the Corporate Identity: A Study Focused on the Websites of Spanish Financial Entities 显示文摘 | Bravo R Matute J Pina J M | 2012 | Journal of Business Ethics2012，107，2： | 1 |
| 5 | Circulating Ki-67 positive lymphocytes in multiple myeloma and benign monoclonal gammopathy显示文摘 | Garcia M Matutes E Tarin F | 1995 | J Clin Pathol1995，48，9： | 1 |
| 6 | Expression of nerve growth factor in astrocytes of the hippocampal CA1 area following transient forebrain ischemia显示文摘 | Gottlieb M Matute C | 1999 | Neuroscience1999，91，3： | 1 |
| 7 | 18F-FDG positron emission tomography staging and restaging in rectal cancer treated with preoperative chemoradiation显示文摘 | Calvo FA Domper M Matute R | 2004 | Int J Radiat Oncol Biol Phys2004，58，2： | 1 |
| 8 | Molecular mechanisms of neuroprotection by two natural antio-xidant polyphe- nols 显示文摘 | Campos-Esparza M Sanchez-Gomez M Matute C | 2009 | Cell Calcium2009，45，4： | 1 |
| 9 | P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis显示文摘 | Matute C Torre I Perez-Cerda F Perez-Samartin A Alberdi E Etxebar-ria E Arranz AM Ravid R Rodriguez-Antiguedad A Sanchez-Go-mez M Domercq M | | 0，，： | 1 |
| 10 | Synthesis by coprecipitation and study of barium hexaferrite powders显示文摘 | MATUTES A J CASTANON D S GARCIA M M | 2000 | Scripta Mater2000，42，3： | 1 |
| 11 | Fluid and electrolyte disorders following surgery for brain tumors显示文摘 | Segura Matute S Balaguer Gargallo M Cambra Lasaosa FJ | 2007 | An Pediatr(Bare)2007，67，5： | 1 |
| 12 | A case of disseminated infection with Pichia ohmeri 显示文摘 | Matute AJ Visser MR Lipovsky M | 2000 | Eur J Clin Microbiol Infect Dis2000，19，12： | 1 |
| 13 | Memory abilities in children with subtypes of dyscalculia显示文摘 | Rosselli M Matute E Pinto N | 2006 | Dev Neuropsychol2006，30，3： | 1 |
| 14 | Long-term follow-up of 233 patients with hairy cell leukaemia,treated initially with pentostatin or cladribine,at a median of 16 years from diagnosis显示文摘 | Else M Dearden CE Matutes E | | 0，，06： | 1 |
| 15 | Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification 显示文摘 | Matutes E Pickl WF Van' t Veer M | 2011 | Blood2011，117，11： | 1 |
| 16 | Dual-specific phosphatase-6(Dusp6)and ERK mediate AMPA receptor-induced oligodendrocyte death显示文摘 | Domercq M Alberdi E Sanchez-Gomez M V Ariz U Perez-Samartin A Matute C | | 0，，： | 1 |
| 17 | Neuroprotection by tetracyclines 显示文摘 | Domercq M Matute C | 2004 | Trends Pharmacol Sci2004，25，： | 1 |
| 18 | Expression of nerve growth factor in astrocytes of the hippocampal CA1area Following transient forebrain ischemia 显示文摘 | Matute C | 1999 | Neuroscience1999，91，3： | 1 |
| 19 | The link between excitotoxic oligodendroglial death and demyelinating diseases显示文摘 | Matute C Alberdi E Domercq M | 2001 | Trends Neurosci2001，24，4： | 1 |
| 20 | Neuroprotection by tetracyclines显示文摘 | Domercq M Matute C | 2004 | Trends Pharmacol Sci2004，25，12： | 1 |
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