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| 1 | An experimental study on the effects of physical, mechanical, and electrochemical properties of natural cohesive soils on critical shear stress and erosion rate显示文摘连贯的沉积侵蚀的地仍然不充分被理解,在由于影响连贯的沉积 erodibility 的许多土壤参数的大部分。在几件没受到干扰的自然土壤样品在 Manitoba 从不同河岸被拿的这研究,加拿大。样品主要与 24-94% 泥土内容包含了泥土和淤泥,因此,学习盖住大量连贯的土壤。为每件样品, 13 个不同物理、机械、电气化学的性质被测量。批评砍侵蚀和侵蚀率的应力用一台侵蚀测量设备(EMD ) 被确定。逐步的回归被用来发现变量最显著地相关到批评砍应力和侵蚀评价,它导致了一个新实验方程的发展估计批评砍连贯的土壤的应力。这被发现批评砍应力高度与结合被相关,当结合和钠吸附比率(SAR ) 在侵蚀上有重要影响时,评价。 | Navid Kimiaghalam Shawn R Clark Habib Ahmari | 2016 | International Journal of Sediment Research2016，31，1： | 5 |
| 2 | Advances in the treatment of cervical rheumatoid: Less surgery and less morbidity显示文摘Rheumatoid arthritis is a chronic systemic inflammatory disease that often affects the cervical spine.While it was initially thought that cervical involvement was innocuous,natural history studies have substantiated the progressive nature of untreated disease.Over the past 50 years,there has been further elucidation in the pathophysiology of the disease,as well as significant advancements in medical and surgical therapy.The introduction of disease modifying drugs and biologic agents has reduced the amount of patients with advanced stages of the disease needing surgery.Advancement in instrumentation techniques has improved patient outcomes and fusion rates.The introduction of endoscopic approaches for ventral decompression may further lower surgical morbidity.In this review,we give a brief overview of the pertinent positives of the disease.A discussion of historical techniques and the evolution of surgical therapy into the modern era is provided.With improved medical therapies and lessinvasive approaches,we will likely continue to see less advanced cases of disease and less surgical morbidity.Nonetheless,a thorough understanding of the disease is crucial,as its systemic involvement and need for continued medical therapy have tremendous impact on overall complications and outcomes even in patients being seen for standard degenerative disease with comorbid rheumatoid. | Grant W Mallory Sasha R Halasz Michelle J Clarke | 2014 | World Journal of Orthopedics2014，5，3： | 5 |
| 3 | Skin-gut axis:The relationship between intestinal bacteria and skin health显示文摘The gut microbiome is an emerging area of interest in medicine. Imbalances in the gut microbiome have been linked to a number of disease states such as obesity and type 2 diabetes. The relationship between normally residing intestinal bacteria(the gut microbiota) and their potential role in the pathogenesis of skin diseases is an area of research for which we are only beginning to understand. Small studies have demonstrated underlying changes in the gut microbiome of patients with certain dermatological diseases. Interestingly, studies suggest that probiotics may have a role in the treatment of atopic dermatitis. However, the concept of the 'skin-gut axis' is a newly emerging and important avenue of investigation, still lacking in pathobiological explanations. This review will introduce and describe the intestinal microbiome as it relates to skin health in a complex communication network between the immune system, endocrine system, metabolic system, and nervous system. | Alexandra R Vaughn Manisha Notay Ashley K Clark Raja K Sivamani | 2017 | World Journal of Dermatology2017，6，4： | 4 |
| 4 | Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival:an overview of the randomised trials显示文摘 | Clarke M Collins R Darby S | | 0，，9503： | 3 |
| 5 | Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8^+ T cells during pregnancy显示文摘Listeria monocytogenes (Lm ) 为发展中的胎儿在怀孕和疾病的后果期间是有为全身的母亲的感染的唯一的倾向的一个细胞内部的细菌。给与出生前的 Lm 感染联系的高死亡,为在怀孕的极其脆弱的经期期间扩充保护的免疫的策略着急地被需要。此处,保护由在对随后的剧毒的 Lm 出生前的感染的怀孕被评估以前,管理的稀释 Lm 交谈了。因为显著地更多的细菌从母亲的纸巾被恢复,我们证明对在非怀孕的老鼠的第二等的 Lm 感染的保护严厉地在 allogeneic 怀孕期间被节制,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。更重要地,因为各在怀孕和天真的怀孕控制以前与稀释 Lm 接种的老鼠在怀孕期间在 Lm 感染以后从单个 concepti 显示出近完全的胎儿的再吞和病原体恢复, preconceptual priming 不在 utero 侵略或胎儿的消耗量免于。显著地,对有在 allogeneic 怀孕的 preconceptual priming 的出生前的 Lm 感染的保护的缺乏在 syngeneic 怀孕期间被恢复。因此,母亲胎儿的抗原不和在出生前的 Lm 感染以后对胎儿的复杂并发症支配 preconceptual 种痘的低效率,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。 | Dayna R Clark Vandana Chaturvedi Jeremy M Kinder Tony T Jiang Lijun Xin James M Ertelt Sing Sing Way | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 6 | SiC for microwave power transistors 显示文摘 | SRIRAM S SIERGIEJ R R CLARKE R C etal | 1997 | Phys Status Solidi A1997，162，： | 2 |
| 7 | 壳牌对未来车用能源多元化发展趋势的思考显示文摘面对能源短缺和环境污染的双重挑战,交通领域的转型升级不可避免。本文结合未来车用动力系统的发展趋势,对交通运输领域中应用的多种先进动力系统、清洁能源及替代燃料进行综述和评价,包括目前主要使用的传统液态化石燃料即汽、柴油及先进内燃机技术,清洁替代燃料(如生物燃料、天然气合成油(GTL)燃料、电转液(PTL)燃料、液化天然气(LNG)等),以及电气化动力系统(包括混合动力、纯电动和燃料电池)等,并着重讨论液体燃料。壳牌认为没有一种单一的解决方案可以解决复杂的能源问题,未来交通能源结构将呈现多种能源并存的特点,并分别适用于不同的场景。该文还介绍了壳牌近期基于不同政治、经济和社会发展程度提出的3种远景(壳牌“高山”、“海洋”和“天空”远景),提出壳牌对未来车用能源领域转型脱碳发展情景的思考。 | 贾恬 郑彬 Warnecke W Kolbeck A Aradi A Kofod M Clark R Wilbrand K | 2020 | 汽车安全与节能学报2020，11，1： | 2 |
| 8 | Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation. | Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 9 | Molecular microbial ecology of lignocellulose mobilisation as a carbon source in mine drainage wastewater treatment显示文摘 | Clarke AM Kirby R Rose PD | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 10 | Thermal degradation of Nicalon SiC fiber 显示文摘 | CLARK T J ARONS R M STAMATOFF J B | 1985 | Ceram Eng Sci Proc1985，6，78： | 2 |
| 11 | Isolation of an unidentified agent from the respiratory tract of chickens显示文摘 | Bankowski R A Corstert R E Clark C T | 1960 | Science1960，132，： | 2 |
| 12 | Theory and simulation of high-power microwave generation in a magnetically insulated transmission line oscillator显示文摘 | Lemke R W Clark M C | 1987 | J App Phys1987，62，8： | 2 |
| 13 | Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β显示文摘 | Quanlong Lu Zhigang Lu Qinying Liu Li Guo He Ren Jingyan Fu Qing Jiang Paul R Clarke Chuanmao Zhang | 2012 | Cell Research2012，22，11： | 2 |
| 14 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 15 | Fate of metals in waste combustion systems 显示文摘 | Barton R G Clark W D Seeker W R | 1990 | Combustion Science and Technology1990，74，： | 1 |
| 16 | Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific methad of detection of Salmonella显示文摘 | Rahn K Grandis S A Clarke R C | 1992 | Mol Cell Probes1992，6，4： | 1 |
| 17 | Origins of breast cancer subtypes and therapeutic implications 显示文摘 | Sims AH Howell A Howell S J Clarke R B | 2007 | Nature Clin Pract Oncol2007，4，12： | 1 |
| 18 | Meningeal melanocytoma:Report of a case and a historical comparison显示文摘 | Clarke DB Leblane R Bertrand G | 1998 | J Neurosurg1998，88，1： | 1 |
| 19 | Role of microfilaments in maintenance of proximal tubular structure and functional integrity 显示文摘 | Kellerman P S Clark R A Hoilien C A | 1990 | Am J Physiol1990，259，2： | 1 |
| 20 | The persistence and degradation of chlorothalonil and chlorpyrifos in a cranberry bog 显示文摘 | Putnam R A Nelson J O Clark J M | 2003 | Agric Food Chem2003，51，： | 1 |
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