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| 1 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 2 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 3 | OsADR3 increases drought stress tolerance by inducing antioxidant defense mechanisms and regulating OsGPX1 in rice(Oryza sativa L.)显示文摘The C (Cys) 2H (His) 2-type transcription factor is one of the most important transcription factors in plants and plays a regulatory role in the physiological responses of rice to abiotic stresses.A novel rice C2H2-type zinc finger protein,abscisic acid (ABA)-drought-reactive oxygen species (ROS) 3 (OsADR3),was found to confer drought stress tolerance by enhancing antioxidant defense and regulating Os GPX1.Overexpression of OsADR3 in rice increased tolerance to drought stress by increasing ROS scavenging ability and ABA sensitivity.In contrast,CRISPR/Cas9-mediated knockout of osadr3 increased the sensitivity of rice to drought and oxidative stress.An exogenous ROS-scavenging reagent restored the droughtstress tolerance of osadr3-CRISPR plants.Global transcriptome analysis suggested that OsADR3 increased the expression of Os GPX1 under drought stress.Electrophoretic mobility shift,yeast one-hybrid,and dualluciferase reporter assays revealed that OsADR3 modified the expression of Os GPX1 by directly binding to its promoter.Knockdown of Os GPX1 repressed ROS scavenging ability under drought stress in OsADR3-overexpression plants.These findings suggest that OsADR3 plays a positive regulatory role in droughtstress tolerance by inducing antioxidant defense and associated with the ABA signaling pathway in rice. | Jiaming Li Minghui Zhang Luomiao Yang Xinrui Mao Jinjie Li Lu Li Jingguo Wang Hualong Liu Hongliang Zheng Zichao Li Hongwei Zhao Xianwei Li Lei Lei Jian Sun Detang Zou | 2021 | The Crop Journal2021，9，5： | 2 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | MappingChina’ s mangroves based on an object-oriented classification of Landsatimagery显示文摘 | JIAM WANGZ LIL SONGK RENC LIUB MAO D | 2013 | Wetlands2013，34，2： | 1 |
| 6 | Intranasal administration of melaton in starch microspheres 显示文摘 | MAO SHIRUI CHEN JIAMING WEI ZHENPING | 2004 | International Journal of Phamaceutics2004，272，12： | 1 |
| 7 | Influence of imidazole derivatives on the dielectric and energy storage performance of epoxy显示文摘Imidazoles are widely used as curing agents and accelerators for fabricating crosslinked epoxy materials applied in electrical and electronic fields.However,the intrinsic chemical structure of imidazole derivatives would greatly influence the polymerisation process,and further change the electrical properties,which was not emphasised.To achieve an in-depth understanding,commonly used imidazole only containing pyridine-type nitrogen and imidazole with both pyridine and pyrrole-type nitrogen were selected in this study.Electrical properties including dielectric properties,volume resistivity,breakdown strength,and especially energy storage performances were systematically investigated.We figured out that higher breakdown strength,glass transition temperature,and lower dielectric loss can be achieved with imidazole containing pyrrole-type nitrogen.Structure-induced curing mechanism diversity and the generated differences in polymer network were highlighted.With the capability to incorporate into the polymer network,the dielectric constant/loss of epoxy cured by imidazole containing pyrrole-type nitrogen is less sensitive with variation in concentration and a high breakdown strength of 577.9 MV/m was achieved.On the contrary,conspicuous decrease in the breakdown strength and increase in dielectric loss of the epoxy cured by imidazole only containing pyridine-type nitrogen were observed,especially at high concentration.Moreover,we also found that the epoxy can be fabricated into films with an attractive energy storage density/efficiency of 1.1 J/cm^(3)/97%@200 MV/m,which is twice of the commercial dielectric polypropylene film under the same electric field. | Jiaming Luo Lei Zhang Wenjie Sun Jiale Mao Yiting Zheng Shuang Wang Ziqi Zhang Yingxin Chen Yonghong Cheng | 2022 | High Voltage2022，7，4： | 1 |
| 8 | Semisupervised Encrypted Traffic Identification Based on Auxiliary Classification Generative Adversarial Network显示文摘The rapidly increasing popularity of mobile devices has changed the methods with which people access various network services and increased net-work traffic markedly.Over the past few decades,network traffic identification has been a research hotspot in the field of network management and security mon-itoring.However,as more network services use encryption technology,network traffic identification faces many challenges.Although classic machine learning methods can solve many problems that cannot be solved by port-and payload-based methods,manually extract features that are frequently updated is time-consuming and labor-intensive.Deep learning has good automatic feature learning capabilities and is an ideal method for network traffic identification,particularly encrypted traffic identification;Existing recognition methods based on deep learning primarily use supervised learning methods and rely on many labeled samples.However,in real scenarios,labeled samples are often difficult to obtain.This paper adjusts the structure of the auxiliary classification generation adversarial network(ACGAN)so that it can use unlabeled samples for training,and use the wasserstein distance instead of the original cross entropy as the loss function to achieve semisupervised learning.Experimental results show that the identification accuracy of ISCX and USTC data sets using the proposed method yields markedly better performance when the number of labeled samples is small compared to that of convolutional neural network(CNN)based classifier. | Jiaming Mao Mingming Zhang Mu Chen Lu Chen Fei Xia Lei Fan ZiXuan Wang Wenbing Zhao | 2021 | Computer Systems Science & Engineering2021，39，12： | 1 |
| 9 | Argonaute(AGO)proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells(MSCs)显示文摘As multipotent progenitor cells,mesenchymal stem cells(MSCs)can renew themselves and give rise to multiple lineages including osteoblastic,chondrogenic and adipogenic lineages.It’s previously shown that BMP9 is the most potent BMP and induces osteogenic and adipogenic differentiation of MSCs.However,the molecular mechanism through which BMP9 regulates MSC differentiation remains poorly understood.Emerging evidence indicates that noncoding RNAs,especially microRNAs,may play important roles in regulating MSC differentiation and bone formation.As highly conserved RNA binding proteins,Argonaute(AGO)proteins are essential components of the multi-protein RNA-induced silencing complexes(RISCs),which are critical for small RNA biogenesis.Here,we investigate possible roles of AGO proteins in BMP9-induced lineage-specific differentiation of MSCs.We first found that BMP9 upregulated the expression of Ago1,Ago2 and Ago3 in MSCs.By engineering multiplex siRNA vectors that express multiple siRNAs targeting individual Ago genes or all four Ago genes,we found that silencing individual Ago expression led to a decrease in BMP9-induced early osteogenic marker alkaline phosphatase(ALP)activity in MSCs.Furthermore,we demonstrated that simultaneously silencing all four Ago genes significantly diminished BMP9-induced osteogenic and adipogenic differentiation of MSCs and matrix mineralization,and ectopic bone formation.Collectively,our findings strongly indicate that AGO proteins and associated small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs. | Yukun Mao Na Ni Linjuan Huang Jiaming Fan Hao Wang Fang He Qing Liu Deyao Shi Kai Fu Mikhail Pakvasa William Wagstaff Andrew Blake Tucker Connie Chen Russell R.Reid Rex C.Haydon Sherwin H.Ho Michael J.Lee Tong-Chuan He Jian Yang Le Shen Lin Cai Hue H.Luu | 2021 | Genes & Diseases2021，8，6： | 1 |
| 10 | Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older—China,1998-2018显示文摘Summary What is already known about this topic?Limited evidence on healthy longevity was provided in the world,and no studies investigated the fractions of healthy longevity attributed to modifiable factors.What is added by this report?Incidences of longevity and healthy longevity in China are provided.It reveals that the total weighted population attributable fractions for lifestyles and all modifiable factors were 32.8% and 83.7% for longevity,respectively,and 30.4% and 73.4% for healthy longevity,respectively.What are the implications for public health practice?China has a high potential for longevity and healthy longevity.Strategies may be targeted at education and residence in early life as well as healthy lifestyles,disease prevention,and functional optimization in late life. | Jinhui Zhou Xiang Gao Yuan Wei Chen Chen Jun Wang Zhenwei Zhang Xinwei Li Lihong Ye Jiaming Ye Sixin Liu Xiaochang Zhang Feng Zhao Juan Zhang Virginia Byers Kraus Yuebin Lyu Chen Mao Xiaoming Shi | 2023 | China CDC weekly2023，5，2： | 0 |
| 11 | Perspective on antiferroelectrics for energy storage and conversion applications显示文摘As a close relative of ferroelectricity,antiferroelectricity has received a recent resurgence of interest driven by technological aspirations in energy-efficient applications,such as energy storage capacitors,solid-state cooling devices,explosive energy conversion,and displacement transducers.Though prolonged efforts in this area have led to certain progress and the discovery of more than 100 antiferroelectric materials over the last 70 years,some scientific and technological issues remain unresolved.Herein,we provide perspectives on the development of antiferroelectrics for energy storage and conversion applications,as well as a comprehensive understanding of the structural origin of antiferroelectricity and field-induced phase transitions,followed by design strategies for new lead-free antiferroelectrics.We also envision unprecedented challenges in the development of promising antiferroelectric materials that bridge materials design and real applications.Future research in these directions will open up new possibilities in resolving the mystery of antiferroelectricity,provide opportunities for comprehending structure-property correlation and developing antiferroelectric/ferroelectric theories,and suggest an approach to the manipulation of phase transitions for real-world applications. | Fangping Zhuo Huimin Qiao Jiaming Zhu Shuize Wang Yang Bai Xinping Mao Hong-Hui Wu | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 12 | A CPK-Based Identity Authentication Scheme for IoT显示文摘As the power Internet of Things(IoT)enters the security construction stage,the massive use of perception layer devices urgently requires an identity authentication scheme that considers both security and practicality.The existing public key infrastructure(PKI)-based security authentication scheme is currently difficult to apply in many terminals in IoT.Its key distribution and management costs are high,which hinders the development of power IoT security construction.Combined Public Key(CPK)technology uses a small number of seeds to generate unlimited public keys.It is very suitable for identity authentication in the power Internet of Things.In this paper,we propose a novel identity authentication scheme for power IoT.The scheme combines the physical unclonable function(PUF)with improved CPK technology to achieve mutual identity authentication between power IoT terminals and servers.The proposed scheme does not require third-party authentication and improves the security of identity authentication for power IoT.Moreover,the scheme reduces the resource consumption of power IoT devices.The improved CPK algorithm solves the key collision problem,and the third party only needs to save the private key and the public key matrix.Experimental results show that the amount of storage resources occupied in our scheme is small.The proposed scheme is more suitable for the power IoT. | Mingming Zhang Jiaming Mao Yuanyuan Ma Liangjie Xu Chuanjun Wang Ran Zhao Zhihao Li Lu Chen Wenbing Zhao | 2022 | Computer Systems Science & Engineering2022，40，3： | 0 |
| 13 | Immobilization of Functionalized Ionic Liquid on Sol-Gel Derived Silica for Efficient Removal of H_2S显示文摘An innovative approach to H2 S capture has been developed using several metal-based ionic liquids([Bmim]Cl·CuCl_2, [Bmim]Cl·FeCl_3, [Bmim]Cl·ZnCl_2, [Bmim]Br·CuCl_2, and [Bmim]Br·FeCl_3) immobilized on the sol-gel derived silica, which is superior to purely viscous ionic liquid with a crucial limit of high temperature, low mass transfer rate,and mass loss. The adsorbents were characterized by the Fourier transform infrared spectrometer, transmission electron microscope, N_2 adsorption/desorption, X-ray photoelectron spectroscopy, and thermal analysis techniques. The effects of the metal and halogen in IL, the loading amount of IL, and the adsorption temperature were studied by dynamic adsorption experiments at a gas flow rate of 100 mL/min. The H2 S adsorption results have showed that the optimal adsorbent and adsorption temperature are 5% [Bmim]Cl·CuCl_2/silica gel and 20—50 ℃, respectively. H_2 S can be captured and oxidized to elemental sulfur, and [Bmim]Cl·CuCl_2/silica gel can be readily regenerated by air. The excellent efficiency of H2 S removal may be attributed to the formation of nano-scaled and high-concentration [Bmim]Cl·CuCl_2 confined in silica gel, indicating that the immobilization of [Bmim]Cl·CuCl_2 on the sol-gel derived silica can be used for H2 S removal promisingly. | Ma Yunqian Mao Jiaming Xiao Cong Li Yan Zang Lihua | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，1： | 0 |
| 14 | Trilayered Fibrous Dressing with Wettability Gradient for Spontaneous and Directional Transport of Massive Exudate and Wound Healing Promotion显示文摘Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing process.In wound exu-date management,dressings with unidirectional liquid transport capability have exhibited enormous potential.However,it remains challenging to improve the one-way liquid transport efficiency.Herein,a trilayered fibrous dressing is constructed by sequentially electrospinning polyurethane(PU)and polyvinylidene fluoride(PVDF)onto cotton fabric.Through hot pressing,a stable wettability gradient is formed across the PVDF/PU/cotton dressing due to the melting and bridging of PU nanofib-ers.The trilayered dressing exhibited rapid unidirectional transport with water penetrating from the hydrophobic side to the hydrophilic side in 6 s.The hydrostatic pressure from the hydrophilic side to the hydrophobic side is 569%higher than that from the hydrophobic side to the hydrophilic side,indicating that the dressing has a profound unidirectional conductivity.In vivo experiments demonstrates that the trilayered dressing can accelerate the wound healing process,especially in the early stages of wound occurrence,by quickly draining the excessive exudate.This study provides a new method to construct wound dressings with wettability gradients,which are advantageous for efficient exudate removal. | Lei Liu Hengqiu Sun Jiaming Zhang Bingjie Xu Yujie Gao Dongming Qi Zhengwei Mao Jindan Wu | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
| 15 | Recent research progress on the phase-field model of microstructural evolution during metal solidification显示文摘Solidification structure is a key aspect for understanding the mechanical performance of metal alloys,wherein composition and casting parameters considerably influence solidification and determine the unique microstructure of the alloys.By following the principle of free energy minimization,the phase-field method eliminates the need for tracking the solid/liquid phase interface and has greatly accelerated the research and development efforts geared toward optimizing metal solidification microstructures.The recent progress in the application of phasefield simulation to investigate the effect of alloy composition and casting process parameters on the solidification structure of metals is summarized in this review.The effects of several typical elements and process parameters,including carbon,boron,silicon,cooling rate,pulling speed,scanning speed,anisotropy,and gravity,on the solidification structure are discussed.The present work also addresses the future prospects of phase-field simulation and aims to facilitate the widespread applications of phase-field approaches in the simulation of microstructures during solidification. | Kaiyang Wang Shaojie Lv Honghui Wu Guilin Wu Shuize Wang Junheng Gao Jiaming Zhu Xusheng Yang Xinping Mao | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，11： | 0 |
| 16 | Enhanced nanocrystalline stability of BCC iron via copper segregation显示文摘Nanocrystalline alloys are known for their high density of grain boundaries(GBs),which results in low thermal stability and a tendency for coarsening.In this work,we investigated Fe–Cu alloys to explore the effects of Cu concentration on the thermal stability of nanocrystalline samples.Using hybrid molecular dynamics(MD)and Monte Carlo(MC)simulations,annealing treatments of nanocrystalline samples with varied Cu concentrations were conducted.The simulation results revealed that Cu atoms tended to accumulate at GBs.Subsequently,the model with Cu segregation was subjected to mechanical creep loading at various temperatures.Through the analysis of atomic structure evolution during creep deformation,it was found that Cu segregation efficiently stabilizes GBs and restricts their movement.The present findings highlight that the thermal stability of nanocrystalline Fe–Cu alloys can be effectively improved by introducing suitable Cu segregation at GBs. | Feiyang Wang Linshuo Dong Hong-Hui Wu Penghui Bai Shuize Wang Guilin Wu Junheng Gao Jiaming Zhu Xiaoye Zhou Xinping Mao | 2023 | Progress in Natural Science:Materials International2023，33，2： | 0 |
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