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| 1 | Isolation and characterization of halophilic Bacillus sp.BS3 able to produce pharmacologically important biosurfactants显示文摘Objective:To characterize the pharmacological importance of biosurfactants isolated from halophilic Bacillus sp BS3.Methods:Halophilic Bacillus sp.BS3 was isolated from solar salt works,identified by 16S rRNA sequencing and was used for screening their biosurfactant production.Characters of the biosurfactant and their anticancer activity were analyzed and performed in mammary epithelial carcinoma cell at different concentrations.Results:The biosurfactant were characterized by TLC,FTIR and GC-MS analysis and identified as lipopeptide type.GC-MS analysis revealed that,the biosurfactant had various compounds including 13Docosenamide.(Z);Mannosamine,9- and N,N,N',N'-tetramethyl.Surprisingly the antiviral activity was found against shrimp white spot syndrome virus(WSSV) by suppressing the viral replication and significantly raised shrimp survival(P<0.01).Anticancer activity performed in the mammary epithelial carcinoma cell at different concentrations of biosurfactants,among the various concentrations of biosurfactants such as 0.000 25,0.002 5,0.025,0.25 and 2.5 μ g,the 0.25 μ g concentration suppressed the cells significantly(P<0.05) to 24.8%.Conclusions:Based on the findings,the present study concluded that,there is a possibility to develop eco-friendly antimicrobial and anticancer drugs from the extremophilic origin. | MBS Donio SFA Ronica V Thanga Viji S Velmurugan J Adlin Jenifer M Michaelbabu T Citarasu | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，11： | 5 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 5 | Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs显示文摘 | Xian Chen Jason S Cordes Jenifer A | 2006 | Pharmacol Toxicol Methods2006，54，3： | 1 |
| 6 | An error correction model of induced innovation in UK agriculture 显示文摘 | Jenifer P David S Colin T | 2011 | Applied Economics2011，43，1： | 1 |
| 7 | Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blockedl显示文摘 | Simon F S Peter K Jenifer B | 2008 | Cell Cycle2008，7，24： | 1 |
| 8 | Optimization of pressurized liquid extraction of Piper gaudichaudianum Kunth leaves显示文摘 | Valéria F P Jenifer S MariaInês S M | 2006 | J Chromatogr A2006，，12： | 1 |
| 9 | Comparison of soxhlet, ultrasound-assisted and pressurized liquid extraction of terpenes, fatty acids and Vitamin E from Piper gaudichaudianum Kunth显示文摘 | Valaria F P Jenifer S Maria I S M | 2006 | Journal of Chromatography A2006，1105，12： | 1 |
| 10 | Interaction of the yeast Pso5/Rad16 and Sgs1 proteins: influences on DNA repair and aging 显示文摘 | Jenifer S Heidi F Ernst-Ludwig W | 2001 | Mutation Research2001，486，： | 1 |
| 11 | Data Security and Privacy in Cloud Using RC6 and SHA Algorithms显示文摘 | Soundararajan O M Jenifer Y Dhivya S | 2014 | Networking and Com- munication Engineering2014，6，5： | 1 |
| 12 | A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease显示文摘 | ZHANG Qibin JENIFER M A RICHARD D S | 2009 | Journal of Proteome Research2009，8，2： | 1 |
| 13 | Providing Risk Information in Communities:Factors Influencing What Is Heard and Accepted显示文摘 | JUNE FESSENDEN-RADEN JANET M FITCHEN JENIFER S HEATH | | 0，，34： | 1 |
| 14 | Market Liquid- ity and Stock Size Premia in Emerging Financial Markets: The Implications for Foreign Investment 显示文摘 | BRUCE H JENIFER P ROGER S | 2010 | International Business Review2010，19，5： | 1 |
| 15 | Optimization of pressurized liquid 〖JP5〗extraction of Piper gaudichaudianum Kumth leaves显示文摘 | Valéria F P Jenifer S Maria I S | 2006 | Journal of Chromatography A2006，1105，12： | 1 |
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