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| 1 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 2 | EGFR and KRAS in Colorectal Cancer显示文摘 | Ben Markman Francisco Javier Ramos Jaume Capdevila Josep Tabernero | 2010 | Advances in Clinical Chemistry2010，，： | 2 |
| 3 | Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment显示文摘 | Jaume Capdevila Elena Elez Teresa Macarulla Francisco Javier Ramos Manuel Ruiz-Echarri Josep Tabernero | 2009 | Cancer Treatment Reviews2009，，4： | 1 |
| 4 | l-ARGININE REDUCES LIVER AND BILIARY TRACT DAMAGE AFTER LIVER TRANSPLANTATION FROM NON-HEART-BEATING DONOR PIGS1显示文摘 | Ricard Valero Juan C. Garcá-Valdecasas Marc Net Joan Beltran Jaume Ordi Francisco X. González Miguel A. López-Boado Raul Almenara Pilar Taurá Montserrat Elena Lluis Capdevila Mart Manyalich Josep Visa | 2000 | Transplantation2000，，5： | 1 |
| 5 | Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor——an update on neuroendocrine neoplasm’s treatment:A case report显示文摘BACKGROUND Metastatic small bowel low-grade neuroendocrine tumors(NETs)have a good prognosis.Surgery is the only curative treatment;however,this may induce advanced liver disease,particularly in long-term survivor patients.Acquired hepatocerebral degeneration or Parkinsonism in cirrhosis is characterized by rapidly progressive extrapyramidal symptoms in patients with advanced liver disease.CASE SUMMARY A 70-year-old man presented to the emergency department with diminished consciousness and disorientation,and was diagnosed with hepatic encephalopathy.The patient was diagnosed in 1993 with a metastatic small bowel NET,for which he twice underwent hepatic surgery,with metastatic resection in 1993 and a right hepatectomy in 2002 to remove two hepatic metastases.In 2003,the patient started first-line chemotherapy and in 2004 started the first of three consecutive biological treatments,followed by radio-molecular therapy,achieving stable disease for 14 years.Disease progression was identified and he underwent an endoscopic retrograde cholangiopancreatography.However,in 2019 advanced liver disease was identified.We diagnosed the development of acquired hepatocerebral degeneration,an unusual long-term side effect after multiple hepatic procedures.CONCLUSION The importance of regular and ongoing surveillance in long-term NET survivors who undergo hepatic procedures should be integrated into the therapeutic management plan,as some of these negative outcomes could be prevented. | Oriol Mirallas Nadia Saoudi Diego Gómez-Puerto Mar Riveiro-Barciela Xavier Merino Cristina Auger Stefania Landolfi Laia Blanco Amparo Garcia-Burillo Xavier Molero Maria Teresa Salcedo-Allende Jaume Capdevila | 2021 | World Journal of Hepatology2021，13，5： | 0 |
| 6 | Management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy显示文摘Appendiceal neuroendocrine tumors(aNETs)are an uncommon neoplasm that is relatively indolent in most cases.They are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an appendectomy.Although there are numerous clinical practice guidelines on management of a NETs,there is continues to be a dearth of evidence on optimal treatment.Management of these tumors is stratified according to risk of locoregional and distant metastasis.However,there is a lack of consensus regarding tumors that measure 1-2 cm.In these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be considered.Computed tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk factors.Somatostatin receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant disease.The main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node metastases.The main factor considered is tumor size and 2 cm is the most common threshold for indicating a colectomy.Other factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be considered.On the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into consideration.In this review,we present data regarding the current indications,outcomes,and benefits of a colectomy. | JoséLuis Muñoz de Nova Jorge Hernando Miguel Sampedro Núñez Greissy Tibisay Vázquez Benítez Eva María Triviño Ibáñez María Isabel del Olmo García Jorge Barriuso Jaume Capdevila Elena Martín-Pérez | 2022 | World Journal of Gastroenterology2022，28，13： | 0 |
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