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| 1 | Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in U.S. strawberry (Fragaria×ananassa) breeding populations using pedigree-based QTL analysis显示文摘The cultivated strawberry(Fragaria×ananassa)is consumed worldwide for its flavor and nutritional benefits.Genetic analysis of commercially important traits in strawberry are important for the development of breeding methods and tools for this species.Although several quantitative trait loci(QTL)have been previously detected for fruit quality and flowering traits using low-density genetic maps,clarity on the sub-genomic locations of these QTLs was missing.Recent discoveries in allo-octoploid strawberry genomics led to the development of the IStraw90 single-nucleotide polymorphism(SNP)array,enabling high-density genetic maps and finer resolution QTL analysis.In this study,breeder-specified traits were evaluated in the Eastern(Michigan)and Western(Oregon)United States for a common set of breeding populations during 2 years.Several QTLs were validated for soluble solids content(SSC),fruit weight(FWT),pH and titratable acidity(TA)using a pedigree-based QTL analysis approach.For fruit quality,a QTL for SSC on linkage group(LG)6A,a QTL for FWT on LG 2BII,a QTL for pH on LG 4CII and two QTLs for TA on LGs 2A and 5B were detected.In addition,a large-effect QTL for flowering was detected at the distal end of LG 4A,coinciding with the FaPFRU locus.Marker haplotype analysis in the FaPFRU region indicated that the homozygous recessive genotype was highly predictive of seasonal flowering.SNP probes in the FaPFRU region may help facilitate marker-assisted selection for this trait. | Sujeet Verma Jason D Zurn Natalia Salinas Megan M Mathey Beatrice Denoyes James F Hancock Chad E Finn Nahla V Bassil Vance M Whitaker | 2017 | Horticulture Research2017，4，1： | 10 |
| 2 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 4 | Adenomyosis 显示文摘 | Jason M Dechenne V Chantraine F | 2013 | Rev Med Liege2013，68，4： | 1 |
| 5 | The effect of per-mafrost thaw on old carbon release and net carbon exchange fromtundra显示文摘 | EdwardAGS Jason G V Kathryn G C | 2009 | Nature2009，459，7246： | 1 |
| 6 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 7 | Improving software-quality predictions with data sampling and boosting显示文摘 | Chris S Taghi M K Jason V H | 2009 | IEEE Trans- actions on Systems Man and Cybernetics2009，39，6： | 1 |
| 8 | Three- dimensional optical metamaterial with a negative refractive index显示文摘 | JASON V ZHANG Shuang THOMAS Z | 2008 | Nature2008，455，7211： | 1 |
| 9 | Impact of gold mining on the environment and human health:a case study in the Migori gold belt,Kenya显示文摘 | Jason S O Winnie V M Monica A O | 2002 | Environmental Geochemistry and Health2002，24，： | 1 |
| 10 | The molecular basis for apoptotic defects in patients with CD95 (Fas/APO-1) mutations显示文摘 | AKSHAY K V JASON R O JIA L C | 1999 | J Clin Invest1999，103，： | 1 |
| 11 | Accessing the ecological impact of a university: the ecological footprint for the University of Redlands显示文摘 | Jason V | 2001 | International Journal of Sustainability in Higher Education2001，2，2： | 1 |
| 12 | Infrared study of CO2 sorptionover“molecular basket”sorbent consisting of polyethylenimine-modi-fied mesoporous molecular sieve显示文摘 | Wang X X Schwartz V Jason C C | 2009 | Journal of Physical Chemistry C2009，113，17： | 1 |
| 13 | Evidence for multiple mechanisms of toxicity in larval rainbow trout(Oncorhynchus mykiss)cotreated with retene and α-naphthoflavone显示文摘 | Jason A S Peter V H | 2008 | Aquatic Toxicology2008，28，3： | 1 |
| 14 | Knowledge discovery from imbalanced and noisy data显示文摘 | Jason V H Taghi K | 2009 | Data&Knowledge Engineering2009，68，： | 1 |
| 15 | Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis显示文摘 | Jason J Zoeller John M Whitelock Renato V Iozzo | | 0，，05： | 1 |
| 16 | Characterization of microporous separators for lithium-ion batteries显示文摘 | Ganesh V John M Jason H | 1999 | Power Sources1999，77，1： | 1 |
| 17 | Temporal patterns in perchlorate, thiocyanate and iodide excretion in human milk显示文摘 | Andrea B Kirk Jason V Dyke Clyde F Martin et al | 2007 | Environmental Health Perspectives2007，115，2： | 1 |
| 18 | Role of disinfectant concentration and pH in the inactivation kinetics of Cryptosporidium parvum oocysts with ozone and monochloramlne 显示文摘 | Jason L R Jae H K Benito C V | 2001 | Environmental Science and Technology2001，35，13： | 1 |
| 19 | A meta-analysis of con-text-dependency in plant response to inoculation with mycor-rhizal fungi显示文摘 | Jason D Hoeksema V Chaudhary B | 2010 | Ecology Letters2010，13，： | 1 |
| 20 | Spermine compaction is an efficient and economical method of producting vaccine-grande DNA显示文摘 | Dan V Mourich Michael W Munks Jason C Murphy | 2003 | Journal of Immunological Methods2003，27，： | 1 |
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