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| 1 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 2 | Acute heart failure and early development of left ventricular dysfunction in pstients with ST segment elevation acute myocardial infarction 'managed with primary percutaneous coronary intervention 显示文摘 | Parenica J Kala P Jarkovsky J | 2011 | Vnitr Lek2011，57，1： | 1 |
| 3 | Relationship between high aortic pulse pressure and extension of coronary atherosclerosis in males显示文摘 | Payenica J Kala P Jarkovsky J etal | 2011 | Physiol Res2011，60，1： | 1 |
| 4 | Effect of spironolactone in resistantarterial hypertension: a randomized, double-blind, placebo-controlled trial( AS-PIRANT-EXT) 显示文摘 | Vaclavik J Sedlak R Jarkovsky J | 2014 | Medicine ( Baltimore)2014，93，27： | 1 |
| 5 | Parasite communities of freshwater fish under flood conditions 显示文摘 | Kadlec D gimkova A Jarkovsky J | 2003 | Parasitol Res2003，89，： | 1 |
| 6 | Relationship Between High Aortic Pulse Pressure and Extension of Coronary Atherosclerosis in Males显示文摘 | Parenica J Kala P Jarkovsky J Poloczek M Bocek O Jerábek P Neugebauer P Vytiska M Parenicová I Tomcíková D Goldbergová M Pávková Spinar J | 2011 | Physiological Research2011，，1： | 1 |
| 7 | Prediabetes/early diabetes‐associated neuropathy predominantly involves sensory small fibres显示文摘 | Sarka Divisova Eva Vlckova Maria Hnojcikova Miroslav Skorna Martin Nemec Petr Dubovy Ladislav Dusek Jiri Jarkovsky Jana Belobradkova Josef Bednarik | 2012 | Journal of the Peripheral Nervous System2012，，3： | 1 |
| 8 | Substrate specificity of haloalkane dehalogenases 显示文摘 | Koudelakova T Chovancova E Brezovsky J Monincova M Fortova A Jarkovsky J Damborsky J | 2011 | Biochem J2011，435，： | 1 |
| 9 | The logarithm of the triglycerlde/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia显示文摘 | Soska V Jarkovsky J Ravcukova B | 2012 | Clinbiochem2012，45，12： | 1 |
| 10 | S-lOOb pro-tein elevation in patients with the acute coronary syn-drome after resuscitation is a predictor of adverse neuro-logical prognosis 显示文摘 | Heldnovd K Parenica J Jarkovsky J | 2012 | Vnitr Lek2012，58，4： | 1 |
| 11 | The logarithm of the triglycer- ide/HDL-cholesterol ratio is related to the history of cardiovascular dis- ease in patients with familial hypercholesterolemia 显示文摘 | Soska V Jarkovsky J Ravcukova B | 2012 | Clin Biochem2012，45，12： | 1 |
| 12 | Addition of Spironolactone in Patients With Resistant Arterial Hypertension (ASPIRANT): A Randomized, Double-Blind, Placebo-Controlled Trial显示文摘 | Jan Václavík Richard Sedlák Martin Plachy Karel Navrátil Ji?í Plá?ek Ji?í Jarkovsky Tomá? Václavík Roman Husár Eva Kociánová Milo? Táborsky | 2011 | Hypertension2011，，6： | 1 |
| 13 | Genetic diversity and population structure of pea (Pisum sativum L.) varieties derived from combined retrotransposon, microsatellite and morphological marker analysis显示文摘 | Petr Smykal Miroslav Hybl Jukka Corander Ji?í Jarkovsky Andrew J. Flavell Miroslav Griga | 2008 | Theoretical and Applied Genetics2008，，3： | 1 |
| 14 | Standardised uptake value of <sup>18</sup>F‐FDG on staging PET/CT in newly diagnosed patients with different subtypes of non‐Hodgkin’s lymphoma显示文摘 | Tomá?Papajík MiroslavMyslive?ek Zuzana?edová EvaBuriánková VítProcházka PavelKoranda LuděkRaida ZuzanaKubová MiroslavaPalová LadislavaKu?erová PatrikFlodr Ji?íJarkovsky LadislavDu?ek KarelIndrák | 2010 | European Journal of Haematology2010，，1： | 1 |
| 15 | Relationship between high aortic pulse pressure and extension of coronary atherosclerosis in males显示文摘 | Parenica J Kala O Jarkovsky J | 2011 | Physial Res2011，60，1： | 1 |
| 16 | Acute heart failure and early development of left ventricular dysfunction in patients with ST segment elevation acute myocardial infarction managed with primary percutanceous coronary in tevention显示文摘 | Parenica J Kala P Jarkovsky J | 2011 | Vnitr Lek2011，57，1： | 1 |
| 17 | The as-sociation between levels of tissue inhibitor of metallopro- teinase - 1 with acute heart failure and left ventricular dysfunction in patients with ST elevation myocardial in- farction treated by primary percutaneous coronary interven- tion显示文摘 | Goldbergova MP Parenica J Jarkovsky J | 2012 | Genet Test Mol Biomarkers2012，16，10： | 1 |
| 18 | Addition of Spironolactone in Patients With Resistant Arterial Hypertension (ASPIRANT): A Randomized, Double-Blind, Placebo-Controlled Trial显示文摘 | Jan Václavík Richard Sedlák Martin Plachy Karel Navrátil Ji?í Plá?ek Ji?í Jarkovsky Tomá? Václavík Roman Husár Eva Kociánová Milo? Táborsky | 2011 | Hypertension2011，，6： | 1 |
| 19 | Variability of soil microbial properties: effects of sampling, handling and storage显示文摘 | Cernohlavkova J Jarkovsky J Nesporova M | 2009 | Ecotoxicology and Environmental Safety2009，72，8： | 1 |
| 20 | Relationship between high aortic pulse pressure and extension of coronary atherosclerosis in males 显示文摘 | Parenica J Kala P Jarkovsky J | 2011 | Physiol Res2011，60，1： | 1 |
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