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| 1 | Colorectal cancer screening:20 years of development and recent progress显示文摘Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily increasing.This trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality rates.Each year,approximately 8000 people are diagnosed with CRC and some 4000 die from this malignancy.Twenty years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in 2000.Originally,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT positivity.The program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of gynecologists.Since the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening program.The overall program expanded to cover 25.0%of the target population by 2011.However,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared. | Miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik Bohumil Seifert Ladislav Dusek | 2014 | World Journal of Gastroenterology2014，20，14： | 16 |
| 2 | How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?显示文摘The incidence and prevalence of metabolic syndrome(MS) and colorectal cancer(CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions(adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same- obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian(Asia-Pacific Colorectal Screening Score; APCS) and Polish populations. | Stepan Suchanek Tomas Grega Ondrej Ngo Gabriela Vojtechova Ondrej Majek Petra Minarikova Nagyija Brogyuk Bohus Bunganic Bohumil Seifert Ladislav Dusek Miroslav Zavoral | 2016 | World Journal of Gastroenterology2016，22，36： | 10 |
| 3 | Colorectal cancer screening in Europe显示文摘Colorectal cancer(CRC)is the second most frequent malignant disease in Europe.Every year,412 000people are diagnosed with this condition,and 207 000patients die of it.In 2003,recommendations forscreening programs were issued by the Council of the European Union(EU),and these currently serve as thebasis for the preparation of European guidelines forCRC screening.The manner in which CRC screening iscarried out varies significantly from country to countrywithin the EU,both in terms of organization and thescreening test chosen.A screening program of onesort or another has been implemented in 19 of 27 EUcountries.The most frequently applied method is testing stool for occult bleeding(fecal occult blood test,FOBT).In recent years,a screening colonoscopy hasbeen introduced,either as the only method(Poland)orthe method of choice(Germany,Czech Republic). | Miroslav Zavoral Stepan Suchanek Filip Zavada Ladislav Dusek Jan Muzik Bohumil Seifert Premysl Fric | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 4 | Clinical outcomes of radiofrequency catheter ablation of atrial fibrillation in octogenarians lO-year experience of a one high-volume center显示文摘Background Prevalence of atrial fibrillation (AF) increases with age. Radiofrequency catheter ablation (RFCA) is an establishedtreatment option superior to antiarrhythmics (AAs). In this study, we investigated safety and efficacy of RFCA of AF in octogenarians.Methods From our database, we extracted procedural and follow-up data for patients 〉 80 years with symptomatic AF undergoing RFCAand compared this population to RFCA patients 〈 50 years. All patients underwent pulmonary vein isolation (PVI) supplemented by linearlesions in PVI-nonresponders. Arrhythmia-free survival was assessed using seven day Holter every three months post procedure. All patientscompleted their 12 months follow-up. Results Fifty patients aged ≥80 years (80.5 ± 1.6 years) were compared to 259 patients aged 〈 50years (43.5±5.5 years). The RFCA complication rate did not vary between groups. No differences in procedural characteristics were seenafter being analyzed by type of AF. Among patients with paroxysmal AF, 71.4% octogenarian vs. 84.7% young patients was free of anyarrhythmia, without AAs, after single procedure. For non-paroxysmal AF, arrhythmia-free survival without AAs, was considerably lower(58.6% octogenarians vs. 81.2% younger patients, P = 0.023). If AAs were used, arrhythmia-free survival for paroxysmal AF increased to90.5% and 92.1% in octogenarians and younger patients, respectively; and in non-paroxysmal AF it increased to 79.3% vs. 88.4%. ConclusionsRFCA is a safe and effective strategy to achieve normal sinus rhythm in a highly selected group of octogenarians. Paroxysmal AF ablation inoctogenarians has similar clinical effectiveness as that seen in much younger patients. Non-paroxysmal AF ablation has lower, but still rea-sonable clinical effectiveness. | Alan Bulava Jiri Hanis Ladislav Dusek | 2017 | Journal of Geriatric Cardiology2017，14，9： | 5 |
| 5 | Adolescent coping styles and perceptions of parental child rearing显示文摘 | Dusek J B Danko M | | 0，，04： | 1 |
| 6 | Pretreatment plasma folate modulates the pharmacodynaic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma : 'folate overrescue' concept revisited显示文摘 | Sterba J Dusek L Demlova R | 2006 | Clin Chem2006，52，4： | 1 |
| 7 | Anion-free bambusuril and Its supramolecular properties显示文摘 | Svec J Dusek M | 2011 | Chem Eur J2011，17，： | 1 |
| 8 | Quantification of the superior lateral pterygoid insertion on TMJ compeonents显示文摘 | Dusek TO Kiely M | 1991 | J Dent Res1991，7042，： | 1 |
| 9 | Advances in solution of modulated structures reflected by Jana system 显示文摘 | Dusek M Petricek V Palatinus L | 2010 | Journal of Physics: Conference Series2010，226，01： | 1 |
| 10 | Sentinel lymph node status in patients with locally advanced cervical cancers and impact of neoadjuvant chemothera-py显示文摘 | Slama J Dundr P Dusek L | | 0，，： | 1 |
| 11 | Ihde' s Instrumental Realism and the Marxist Account of Technology in Experimental Science显示文摘 | Dusek V | 2008 | Techne2008，12，： | 1 |
| 12 | Assessing the performance of crack detection tests for solder joints显示文摘 | Ridout S Dusek M Bailey C | 2006 | Microelectronics and Reliability2006，46，12： | 1 |
| 13 | The Baikal scullcap (Scutellariabaicalensis Georgi)a potential source of new drugs显示文摘 | Dusek J | 2002 | Ces2ka Slov Farm2002，51，6： | 1 |
| 14 | Transient aplastic crisis in a leukemic child caused by parvovirus B19 infection 显示文摘 | Mihal V Dusek J Hajduch M | 1996 | Pediatr Hematol Oncol1996，13，2： | 1 |
| 15 | diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies 显示文摘 | Vlckovd-Moravcovd E Bednarik J Dusek L | 2008 | Muscle nerve2008，37，： | 1 |
| 16 | Preparation of methyl phenyldiethoxysilane by a one-step Grignard synthesis 显示文摘 | Tichy V Dusek R Moudry V | 1961 | Chem Prum1961，11，： | 1 |
| 17 | Monitoring microbial biomass and respiration in different soils from the Czech Republie显示文摘 | Hofman J Dusek L Kkinova J | 2004 | Environment International2004，30，： | 1 |
| 18 | Transition on swollen polymer networks induced by intramolecular condensation显示文摘 | Dusek K Patterson K | 1968 | J Polym Sci:Polym Phys1968，6，7： | 1 |
| 19 | Evaluation of cropwater stress index for LEPA irrigated maize 显示文摘 | YAZAR A HOWELL T A DUSEK D A | 1999 | Irrigation Science1999，18，4： | 1 |
| 20 | Activity of nitrifying populations in grassland soil polluted by polychlorinated biphenyls 显示文摘 | Dusek L | 1995 | Plant and Soil1995，176，2： | 1 |
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