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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI显示文摘AIM:To correlate dual-energy computed tomography(DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging(MRI).METHODS:Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced(DCE)-MRI].DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow(PBF),pulmonary blood volume(PBV) and mean transit time(MTT) in visually normal lung parenchyma and perfusion defects.Perfusion parameterswere correlated to mean attenuation values of normal lung and perfusion defects on DECT iodine maps.Two readers rated the concordance of perfusion defects in a visual analysis using a 5-point Likert-scale(1 = no correlation,5 = excellent correlation).RESULTS:In visually normal pulmonary tissue mean DECT and MRI values were:22.6 ± 8.3 Hounsfield units(HU);PBF:58.8 ± 36.0 mL/100 mL per minute;PBV:16.6 ± 8.5 mL;MTT:17.1 ± 10.3 s.In areas with restricted perfusion mean DECT and MRI values were:4.0 ± 3.9 HU;PBF:10.3 ± 5.5 mL/100 mL per minute,PBV:5 ± 4 mL,MTT:21.6 ± 14.0 s.The differences between visually normal parenchyma and areas of restricted perfusion were statistically significant for PBF,PBV and DECT(P < 0.0001).No linear correlation was found between MRI perfusion parameters and attenuation values of DECT iodine maps(PBF:r = 0.35,P = 0.15;PBV:r = 0.34,P = 0.16;MTT:r = 0.41,P = 0.08).Visual analysis revealed a moderate correlation between perfusion defects on DECT iodine maps and the parameter maps of DCE-MRI(mean score 3.6,k 0.45).CONCLUSION:There is a moderate visual but not statistically significant correlation between DECT iodine maps and perfusion parameter maps of DCE-MRI. | Jan Hansmann Paul Apfaltrer Frank G Zoellner Thomas Henzler Mathias Meyer Gerald Weisser Stefan O Schoenberg Ulrike I Attenberger | 2013 | World Journal of Radiology2013，5，5： | 6 |
| 3 | The constituent equation of piezoelectric bi- morphs显示文摘 | SMITS Jan G DALKE Susan I COONEY Thomas K | 1991 | Sensors and Actuator A1991，28，1： | 2 |
| 4 | Environmental pollution due to tanneries and leather manufacturing units in NWFP显示文摘 | Khawaja M A Jan M R Ahmed I 1995 | 1995 | J Anal & Envl Chem1995，3，1： | 1 |
| 5 | Targeting epidermal growth factor receptor in tumors: From conventional mono clonal antibodies via heavy chain-only antibodies to nanobodies 显示文摘 | Altintas I Jan Kok R Schiffelers R M | 2012 | Eur J Pharmae Sci2012，，45： | 1 |
| 6 | Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism显示文摘 | Abdelsamed Hossam Peters Jan Byrne Gerald I | 2013 | Future Microbiology2013，，9： | 1 |
| 7 | IL-12 immunotherapy of minimal re- sidual disease in murine models of HPV16-associated tumours: in- duction of immuneresponses, cytokine production and kinetics of immune cell subsets显示文摘 | Marie I Jana B Jan B | 2008 | Int J Oncol2008，32，2： | 1 |
| 8 | Soft tissue tumours : imaging strategy 显示文摘 | Br i s se H J Orbach D K 1 i jan i enko J | 2010 | Pediatr Radio12010，40，6： | 1 |
| 9 | A 4-geometry maze router and its application on multi-terminal nets显示文摘 | Jan GE Chang KY Gao S Parberry I | | 0，，： | 1 |
| 10 | The Lookahead Strategy for Distance-Based Location Tracking in Wireless Cellular Networks 显示文摘 | I F Tsai R H Jan | 1999 | ACM Sigmobile Mobile Computing and Communications Review1999，3，4： | 1 |
| 11 | Tumor-specific nuclear targeting:promises for anti-cancer therapy?显示文摘 | Alvisi G Poon I K Jans D A | 2006 | Drug Resist Updat2006，9，12： | 1 |
| 12 | The chloroplast calcium sensor CAS is required for photoacclimation in Chlamyclomonas reinhardtii显示文摘 | PETROUTSOS D BUSCH A JAN EN I etal | 2011 | The Plant Cell2011，23，8： | 1 |
| 13 | Identification of dermatophyte species by 28s ribosomal DNA sequencing with a commercial kit显示文摘 | Ninet B Jan I Bontems O | 2003 | J Clin Microbiol2003，41，： | 1 |
| 14 | Improvement of hot working process with PVD coatings and duplex treatment显示文摘 | NAVINSK B PAN JAN P URANKAR I | 2001 | Surface and Coatings Technology2001，，： | 1 |
| 15 | Mathematical modeling of diesel-electric propulsion systems for marine vessels显示文摘 | Jan F H ALF K A THOR I F | 2001 | Mathematical and Computer Modeling of Dynamical Systems2001，7，1： | 1 |
| 16 | On the limits of applicability of spectrophotometer and spectrofluorime tricmethods for the determination of chlorophyll alb ratio 显示文摘 | ROMAN K PETR I JAN N | 1999 | Photo synth Res1999，，62： | 1 |
| 17 | The gene ratios c-MYC:Cyclin-dependent kinase (CDK)N2A and CCND1:CDKN2A correlate with poor prognosis in squamous cell carcinoma of the head and neck显示文摘 | JAN AKERVALLl I PETERSEN KUN YANG | 2003 | Clinical Cancer Research2003，9，： | 1 |
| 18 | 'Click' chemistry by microcontact printing显示文摘 | Dorota I Rozkiewicz Dominik Jan'czewski Willem Verboom | 2006 | Angewandte Chemie International Edition2006，45，32： | 1 |
| 19 | Study of dependability evaluation for multi-hierarchical systems based on max-min composition 显示文摘 | MILOS T DE JAN I PREDRAG J | 2013 | Quality and Reliability Engineering International2013，29，3： | 1 |
| 20 | Optodynamic study of multiple pulse micro drilling 显示文摘 | PETKOVSEK R PAN JAN I BABNIK A MOZINA J | 2006 | Ultrasonics2006，44，： | 1 |
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